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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25326

FusionGeneSummary for OAZ1_FKBP8

check button Fusion gene summary
Fusion gene informationFusion gene name: OAZ1_FKBP8
Fusion gene ID: 25326
HgeneTgene
Gene symbol

OAZ1

FKBP8

Gene ID

4946

23770

Gene nameornithine decarboxylase antizyme 1FK506 binding protein 8
SynonymsAZ1|AZI|OAZFKBP38|FKBPr38
Cytomap

19p13.3

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionornithine decarboxylase antizyme 1ODC-Azantizyme 1peptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase
Modification date2018052320180522
UniProtAcc

P54368

Q14318

Ensembl transtripts involved in fusion geneENST00000582888, ENST00000602676, 
ENST00000322297, ENST00000583542, 
ENST00000588673, 
ENST00000597960, 
ENST00000610101, ENST00000596558, 
ENST00000222308, ENST00000608443, 
ENST00000453489, 
Fusion gene scores* DoF score8 X 6 X 4=19211 X 11 X 5=605
# samples 913
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OAZ1 [Title/Abstract] AND FKBP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOAZ1

GO:0045732

positive regulation of protein catabolic process

17900240


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB153060OAZ1chr19

2269744

+FKBP8chr19

18652807

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000582888ENST00000597960OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000582888ENST00000610101OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000582888ENST00000596558OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000582888ENST00000222308OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000582888ENST00000608443OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000582888ENST00000453489OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000597960OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000610101OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000596558OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000222308OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000608443OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000602676ENST00000453489OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000597960OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000610101OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000596558OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000222308OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000608443OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000322297ENST00000453489OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000597960OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000610101OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000596558OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000222308OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000608443OAZ1chr19

2269744

+FKBP8chr19

18652807

-
5CDS-5UTRENST00000583542ENST00000453489OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000597960OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000610101OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000596558OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000222308OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000608443OAZ1chr19

2269744

+FKBP8chr19

18652807

-
intron-5UTRENST00000588673ENST00000453489OAZ1chr19

2269744

+FKBP8chr19

18652807

-

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FusionProtFeatures for OAZ1_FKBP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OAZ1

P54368

FKBP8

Q14318

Ornithine decarboxylase (ODC) antizyme protein thatnegatively regulates ODC activity and intracellular polyaminebiosynthesis and uptake in response to increased intracellularpolyamine levels. Binds to ODC monomers, inhibiting the assemblyof the functional ODC homodimer, and targets the monomers forubiquitin-independent proteolytic destruction by the 26Sproteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277).Triggers ODC degradation by inducing the exposure of a crypticproteasome-interacting surface of ODC (PubMed:26305948).Stabilizes AZIN2 by interfering with its ubiquitination(PubMed:17900240). Also inhibits cellular uptake of polyamines byinactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4complex mediates the degradation of the CREBBP/EP300 repressorSNIP1. Involved in the translocation of AZIN2 from ER-Golgiintermediate compartment (ERGIC) to the cytosol (PubMed:12097147).{ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240,ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}. Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OAZ1_FKBP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OAZ1_FKBP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OAZ1EGFR, SMAD1, PSMB4, ATXN1, PIAS4, TP73, AZIN1, ODC1, GBE1, UPF1, RAB7A, TAF1B, SRA1, CEPT1, CAMSAP2, GPATCH4, PLXNA3, RNF20, LENG8, PGM2L1, NLGN3, AZIN2, TRIM25FKBP8BCL2, BCL2L1, USP19, BRE, EGFR, HSP90AA1, CALM1, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD6, PSMD7, PSMD11, PSMD12, PSMD13, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB5, PSMB7, ADRM1, PTPRK, UBC, TERF1, EGLN1, CUL3, VHL, ATP13A2, SURF1, MRPL11, YME1L1, UQCRC1, UQCRC2, MRPL15, SSR1, UQCRFS1, PGRMC1, DHODH, NDUFB10, TOMM22, ABCC1, NNT, KCNH2, FKBP8, CAMK2A, CLN3, ADRB2, BNIPL, ARHGEF5, CDK20, PDCL, SUGT1, PTGES3, CACYBP, HSPBP1, RHEB, MTOR, MLST8, RPTOR, RICTOR, CCDC8, RPS6KB2, ABCB7, TCTN2, TCTN3, EVC2, TMEM216, MLH1, XRCC3, VAPA, ATP6AP2, COQ9, TMEM258, CLCN1, CUL4A, CUL4B, MTMR11, PTPMT1, ANKMY2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OAZ1_FKBP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OAZ1_FKBP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource