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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2532

FusionGeneSummary for ARHGEF17_P2RY2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF17_P2RY2
Fusion gene ID: 2532
HgeneTgene
Gene symbol

ARHGEF17

P2RY2

Gene ID

9828

5029

Gene nameRho guanine nucleotide exchange factor 17purinergic receptor P2Y2
SynonymsP164RHOGEF|RHOGEF17|TEM4|p164-RhoGEFHP2U|P2RU1|P2U|P2U1|P2UR|P2Y2|P2Y2R
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 17164 kDa Rho-specific guanine-nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 17Rho-specific guanine-nucleotide exchange factor 164 kDatumor endothelial marker 4P2Y purinoceptor 2ATP receptorP2U nucleotide receptorP2U purinoceptor 1P2U receptor 1purinergic receptor P2Y, G-protein coupled, 2purinoceptor P2Y2
Modification date2018052320180519
UniProtAcc

Q96PE2

P41231

Ensembl transtripts involved in fusion geneENST00000263674, ENST00000536170, 
ENST00000393597, ENST00000311131, 
ENST00000393596, 
Fusion gene scores* DoF score7 X 2 X 5=701 X 1 X 1=1
# samples 71
** MAII scorelog2(7/70*10)=0log2(1/1*10)=3.32192809488736
Context

PubMed: ARHGEF17 [Title/Abstract] AND P2RY2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF17

GO:0030036

actin cytoskeleton organization

12071859


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CN-A498-01AARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263674ENST00000393597ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
5CDS-5UTRENST00000263674ENST00000311131ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
5CDS-5UTRENST00000263674ENST00000393596ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
intron-5UTRENST00000536170ENST00000393597ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
intron-5UTRENST00000536170ENST00000311131ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+
intron-5UTRENST00000536170ENST00000393596ARHGEF17chr11

73022875

+P2RY2chr11

72945201

+

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FusionProtFeatures for ARHGEF17_P2RY2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF17

Q96PE2

P2RY2

P41231

Acts as guanine nucleotide exchange factor (GEF) forRhoA GTPases. {ECO:0000269|PubMed:12071859}. Receptor for ATP and UTP coupled to G-proteins thatactivate a phosphatidylinositol-calcium second messenger system.The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP= ADP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGEF17_P2RY2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGEF17_P2RY2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGEF17SFN, TP53, NXF1, RASL12, WDR83, CAPZA2, MYH9, IQGAP1, SYNPO, ANLN, MYO18A, RERGP2RY2APP, MOV10, SRC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGEF17_P2RY2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneP2RY2P41231DB04786SuraminP2Y purinoceptor 2small moleculeapproved|investigational

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RelatedDiseases for ARHGEF17_P2RY2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource