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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25305

FusionGeneSummary for NXT1_TNRC6B

check button Fusion gene summary
Fusion gene informationFusion gene name: NXT1_TNRC6B
Fusion gene ID: 25305
HgeneTgene
Gene symbol

NXT1

TNRC6B

Gene ID

29107

23112

Gene namenuclear transport factor 2 like export factor 1trinucleotide repeat containing 6B
SynonymsMTR2|P15-
Cytomap

20p11.21

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionNTF2-related export protein 1NTF2-like export factor 1NTX2-like export factor1NUTF-like export factor 1protein p15trinucleotide repeat-containing gene 6B protein
Modification date2018052320180519
UniProtAcc

Q9UKK6

Q9UPQ9

Ensembl transtripts involved in fusion geneENST00000254998, ENST00000301923, 
ENST00000402203, ENST00000454349, 
ENST00000335727, ENST00000497559, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 11 X 5=385
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/385*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NXT1 [Title/Abstract] AND TNRC6B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX492251NXT1chr20

23332278

+TNRC6Bchr22

40447432

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000254998ENST00000301923NXT1chr20

23332278

+TNRC6Bchr22

40447432

-
intron-intronENST00000254998ENST00000402203NXT1chr20

23332278

+TNRC6Bchr22

40447432

-
intron-intronENST00000254998ENST00000454349NXT1chr20

23332278

+TNRC6Bchr22

40447432

-
intron-intronENST00000254998ENST00000335727NXT1chr20

23332278

+TNRC6Bchr22

40447432

-
intron-intronENST00000254998ENST00000497559NXT1chr20

23332278

+TNRC6Bchr22

40447432

-

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FusionProtFeatures for NXT1_TNRC6B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NXT1

Q9UKK6

TNRC6B

Q9UPQ9

Stimulator of protein export for NES-containing proteins(PubMed:10567585). Also plays a role in the nuclear export of U1snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimeris involved in the export of HSP70 mRNA in conjunction withALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).{ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583,ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}. Plays a role in RNA-mediated gene silencing by bothmicro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Requiredfor miRNA-dependent translational repression and siRNA-dependentendonucleolytic cleavage of complementary mRNAs by argonautefamily proteins. As scaffoldng protein associates with argonauteproteins bound to partially complementary mRNAs and simultaneouslycan recruit CCR4-NOT and PAN deadenylase complexes.{ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051,ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NXT1_TNRC6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NXT1_TNRC6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NXT1_TNRC6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NXT1_TNRC6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNRC6BC0032460Polycystic Ovary Syndrome1CTD_human