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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25304

FusionGeneSummary for NXPH3_KAT7

check button Fusion gene summary
Fusion gene informationFusion gene name: NXPH3_KAT7
Fusion gene ID: 25304
HgeneTgene
Gene symbol

NXPH3

KAT7

Gene ID

11248

11143

Gene nameneurexophilin 3lysine acetyltransferase 7
SynonymsNPH3HBO1|HBOA|MYST2|ZC2HC7
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionneurexophilin-3histone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1
Modification date2018052320180523
UniProtAcc

O95157

O95251

Ensembl transtripts involved in fusion geneENST00000328741, ENST00000513748, 
ENST00000259021, ENST00000454930, 
ENST00000509773, ENST00000510819, 
ENST00000424009, ENST00000503935, 
ENST00000435742, ENST00000513980, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NXPH3 [Title/Abstract] AND KAT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKAT7

GO:0006260

DNA replication

16387653

TgeneKAT7

GO:0031098

stress-activated protein kinase signaling cascade

21856198

TgeneKAT7

GO:0043966

histone H3 acetylation

16387653

TgeneKAT7

GO:0043981

histone H4-K5 acetylation

16387653

TgeneKAT7

GO:0043982

histone H4-K8 acetylation

16387653

TgeneKAT7

GO:0043983

histone H4-K12 acetylation

16387653

TgeneKAT7

GO:0043984

histone H4-K16 acetylation

16387653

TgeneKAT7

GO:1900182

positive regulation of protein localization to nucleus

24739512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0DK-01ANXPH3chr17

47653635

+KAT7chr17

47874112

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000328741ENST00000259021NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000328741ENST00000454930NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000328741ENST00000509773NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000328741ENST00000510819NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000328741ENST00000424009NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-5UTRENST00000328741ENST00000503935NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-5UTRENST00000328741ENST00000435742NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000328741ENST00000513980NXPH3chr17

47653635

+KAT7chr17

47874112

+
Frame-shiftENST00000513748ENST00000259021NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000513748ENST00000454930NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000513748ENST00000509773NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000513748ENST00000510819NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000513748ENST00000424009NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-5UTRENST00000513748ENST00000503935NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-5UTRENST00000513748ENST00000435742NXPH3chr17

47653635

+KAT7chr17

47874112

+
5CDS-intronENST00000513748ENST00000513980NXPH3chr17

47653635

+KAT7chr17

47874112

+

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FusionProtFeatures for NXPH3_KAT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NXPH3

O95157

KAT7

O95251

May be signaling molecules that resemble neuropeptides.Ligand for alpha-neurexins (By similarity). {ECO:0000250}. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity towardhistone H3 and is responsible for the bulk of histone H4acetylation in vivo. Involved in H3K14 (histone H3 lysine 14)acetylation and cell proliferation (By similarity). Throughchromatin acetylation it may regulate DNA replication and act as acoactivator of TP53-dependent transcription. Acts as a coactivatorof the licensing factor CDT1 (PubMed:18832067). Specificallyrepresses AR-mediated transcription.{ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470,ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932,ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18832067}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NXPH3_KAT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NXPH3_KAT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NXPH3TAB1, CUL4A, PALD1, TUBA4A, TUBA1A, SUFU, LMF1, DCP2KAT7VIM, CEP70, ZNF165, HOOK2, DVL3, CALCOCO2, NINL, KCTD13, ZBTB8A, AR, ORC1, KATNBL1, PACSIN1, CAAP1, SEPT5, PPID, RGL2, RPS10, WDR33, CBX8, DDX11, ATN1, POLB, SAT1, SNAPIN, ING4, ING5, JADE1, JADE2, JADE3, MEAF6, TP53, HIST1H4A, CDT1, JUN, GMNN, CDC6, ORC2, MCM2, CDK11B, HIST1H3A, HIST2H2AC, CSNK1E, DYNC1I1, HAP1, BARD1, LRIF1, APP, EZH2, RNF2, IFI16, HIST1H2BG, XPO1, DAXX, S100A4, TMPO, ING3, DDB2, POU5F1, BRPF3, BRD1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NXPH3_KAT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NXPH3_KAT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource