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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25299

FusionGeneSummary for NXN_RBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: NXN_RBL2
Fusion gene ID: 25299
HgeneTgene
Gene symbol

NXN

RBL2

Gene ID

64359

5934

Gene namenucleoredoxinRB transcriptional corepressor like 2
SynonymsNRX|TRG-4P130|Rb2
Cytomap

17p13.3

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionnucleoredoxinnucleoredoxin 1retinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2
Modification date2018051920180523
UniProtAcc

Q6DKJ4

Q08999

Ensembl transtripts involved in fusion geneENST00000336868, ENST00000577098, 
ENST00000575801, ENST00000538650, 
ENST00000537628, 
ENST00000262133, 
ENST00000379935, ENST00000544545, 
Fusion gene scores* DoF score9 X 5 X 7=3154 X 3 X 3=36
# samples 124
** MAII scorelog2(12/315*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NXN [Title/Abstract] AND RBL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBL2

GO:0043550

regulation of lipid kinase activity

16286473


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW952727NXNchr17

791922

+RBL2chr16

53513796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000336868ENST00000262133NXNchr17

791922

+RBL2chr16

53513796

+
intron-3UTRENST00000336868ENST00000379935NXNchr17

791922

+RBL2chr16

53513796

+
intron-intronENST00000336868ENST00000544545NXNchr17

791922

+RBL2chr16

53513796

+
intron-3CDSENST00000577098ENST00000262133NXNchr17

791922

+RBL2chr16

53513796

+
intron-3UTRENST00000577098ENST00000379935NXNchr17

791922

+RBL2chr16

53513796

+
intron-intronENST00000577098ENST00000544545NXNchr17

791922

+RBL2chr16

53513796

+
intron-3CDSENST00000575801ENST00000262133NXNchr17

791922

+RBL2chr16

53513796

+
intron-3UTRENST00000575801ENST00000379935NXNchr17

791922

+RBL2chr16

53513796

+
intron-intronENST00000575801ENST00000544545NXNchr17

791922

+RBL2chr16

53513796

+
intron-3CDSENST00000538650ENST00000262133NXNchr17

791922

+RBL2chr16

53513796

+
intron-3UTRENST00000538650ENST00000379935NXNchr17

791922

+RBL2chr16

53513796

+
intron-intronENST00000538650ENST00000544545NXNchr17

791922

+RBL2chr16

53513796

+
intron-3CDSENST00000537628ENST00000262133NXNchr17

791922

+RBL2chr16

53513796

+
intron-3UTRENST00000537628ENST00000379935NXNchr17

791922

+RBL2chr16

53513796

+
intron-intronENST00000537628ENST00000544545NXNchr17

791922

+RBL2chr16

53513796

+

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FusionProtFeatures for NXN_RBL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NXN

Q6DKJ4

RBL2

Q08999

Functions as a redox-dependent negative regulator of theWnt signaling pathway, possibly by preventing ubiquitination ofDVL3 by the BCR(KLHL12) complex. May also function as atranscriptional regulator act as a regulator of proteinphosphatase 2A (PP2A) (By similarity). {ECO:0000250}. Key regulator of entry into cell division. Directlyinvolved in heterochromatin formation by maintaining overallchromatin structure and, in particular, that of constitutiveheterochromatin by stabilizing histone methylation. Recruits andtargets histone methyltransferases KMT5B and KMT5C, leading toepigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potentinhibitor of E2F-mediated trans-activation, associatespreferentially with E2F5. Binds to cyclins A and E. Binds to andmay be involved in the transforming capacity of the adenovirus E1Aprotein. May act as a tumor suppressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NXN_RBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NXN_RBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NXN_RBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NXN_RBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNXNC0009404Colorectal Neoplasms1CTD_human
TgeneRBL2C0023434Chronic Lymphocytic Leukemia1CTD_human
TgeneRBL2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRBL2C0919267ovarian neoplasm1CTD_human