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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25287

FusionGeneSummary for NXF1_CLEC18A

check button Fusion gene summary
Fusion gene informationFusion gene name: NXF1_CLEC18A
Fusion gene ID: 25287
HgeneTgene
Gene symbol

NXF1

CLEC18A

Gene ID

10482

348174

Gene namenuclear RNA export factor 1C-type lectin domain family 18 member A
SynonymsMEX67|TAPMRCL|MRCL1|MRLP2
Cytomap

11q12.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear RNA export factor 1mRNA export factor TAPtip associating proteintip-associated proteinC-type lectin domain family 18 member Amannose receptor-like 1mannose receptor-like protein 2mannose receptor-like protein 3
Modification date2018052320180523
UniProtAcc

Q9UBU9

A5D8T8

Ensembl transtripts involved in fusion geneENST00000531709, ENST00000294172, 
ENST00000532297, ENST00000533048, 
ENST00000531131, ENST00000439713, 
ENST00000393701, ENST00000568461, 
ENST00000288040, ENST00000449317, 
Fusion gene scores* DoF score6 X 7 X 5=2105 X 6 X 1=30
# samples 87
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/30*10)=1.22239242133645
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NXF1 [Title/Abstract] AND CLEC18A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNXF1

GO:0006406

mRNA export from nucleus

19165146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE504888NXF1chr11

62559952

+CLEC18Achr16

70192627

-
ChiTaRS3.1BE551533NXF1chr11

62559952

+CLEC18Achr16

70192627

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000531709ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531709ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531709ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531709ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000294172ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000294172ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000294172ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000294172ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000532297ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000532297ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000532297ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000532297ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000533048ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000533048ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000533048ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000533048ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531131ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531131ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531131ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000531131ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000439713ENST00000393701NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000439713ENST00000568461NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000439713ENST00000288040NXF1chr11

62559952

+CLEC18Achr16

70192627

-
intron-intronENST00000439713ENST00000449317NXF1chr11

62559952

+CLEC18Achr16

70192627

-

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FusionProtFeatures for NXF1_CLEC18A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NXF1

Q9UBU9

CLEC18A

A5D8T8

Involved in the nuclear export of mRNA species bearingretroviral constitutive transport elements (CTE) and in the exportof mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway)(PubMed:10924507). The NXF1-NXT1 heterodimer is involved in theexport of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5components of the TREX complex (PubMed:18364396, PubMed:19165146,PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to betransferred to the NXF1-NXT1 heterodimer for export(PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involvedin nuclear export of m6A-containing mRNAs: interaction betweenSRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to bothSRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).{ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396,ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244,ECO:0000269|PubMed:9660949}. Binds polysaccharides in a Ca(2+)-independent mannerwith a preferentially binding to fucoidan, beta-glucans andgalactans (PubMed:26170455). {ECO:0000269|PubMed:26170455}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NXF1_CLEC18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NXF1_CLEC18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NXF1_CLEC18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NXF1_CLEC18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource