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Fusion gene ID: 25285 |
FusionGeneSummary for NVL_WDR26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NVL_WDR26 | Fusion gene ID: 25285 | Hgene | Tgene | Gene symbol | NVL | WDR26 | Gene ID | 4931 | 80232 |
| Gene name | nuclear VCP-like | WD repeat domain 26 | |
| Synonyms | NVL2 | CDW2|GID7|MIP2|SKDEAS | |
| Cytomap | 1q42.11 | 1q42.11-q42.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear valosin-containing protein-likeNVLp | WD repeat-containing protein 26CUL4- and DDB1-associated WDR protein 2GID complex subunit 7 homologmyocardial ischemic preconditioning upregulated protein 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O15381 | Q9H7D7 | |
| Ensembl transtripts involved in fusion gene | ENST00000391875, ENST00000281701, ENST00000469075, ENST00000482491, ENST00000340871, ENST00000361463, ENST00000468673, | ENST00000414423, ENST00000295024, ENST00000366852, ENST00000479727, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 5 X 6 X 4=120 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/288*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NVL [Title/Abstract] AND WDR26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12K-01A | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| TCGA | RV | UCS | TCGA-N6-A4VG-01A | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000391875 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000391875 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000391875 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000391875 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000281701 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000281701 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000281701 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000281701 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000469075 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000469075 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000469075 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000469075 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000482491 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000482491 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000482491 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000482491 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000340871 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000340871 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000340871 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000340871 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000361463 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-3UTR | ENST00000361463 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000361463 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| 5CDS-intron | ENST00000361463 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000468673 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-3UTR | ENST00000468673 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000468673 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| intron-intron | ENST00000468673 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224574204 | - |
| Frame-shift | ENST00000391875 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| Frame-shift | ENST00000391875 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-3UTR | ENST00000391875 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-intron | ENST00000391875 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| Frame-shift | ENST00000281701 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| Frame-shift | ENST00000281701 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-3UTR | ENST00000281701 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-intron | ENST00000281701 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| Frame-shift | ENST00000469075 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| Frame-shift | ENST00000469075 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-3UTR | ENST00000469075 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-intron | ENST00000469075 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000482491 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000482491 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3UTR | ENST00000482491 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-intron | ENST00000482491 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000340871 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000340871 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3UTR | ENST00000340871 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-intron | ENST00000340871 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| In-frame | ENST00000361463 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| In-frame | ENST00000361463 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-3UTR | ENST00000361463 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| 5CDS-intron | ENST00000361463 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000468673 | ENST00000414423 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3CDS | ENST00000468673 | ENST00000295024 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-3UTR | ENST00000468673 | ENST00000366852 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
| intron-intron | ENST00000468673 | ENST00000479727 | NVL | chr1 | 224499502 | - | WDR26 | chr1 | 224577562 | - |
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FusionProtFeatures for NVL_WDR26 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NVL | WDR26 |
| Participates in the assembly of the telomeraseholoenzyme and effecting of telomerase activity via itsinteraction with TERT (PubMed:22226966). May play a role in 60Sribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053).{ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053,ECO:0000269|PubMed:22226966}. | G-beta-like protein involved in cell signal transduction(PubMed:15378603, PubMed:19446606, PubMed:22065575,PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as anegative regulator in MAPK signaling pathway (PubMed:15378603).Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequentactivation in leukocytes (PubMed:22065575, PubMed:23625927). Actsas a negative regulator of the canonical Wnt signaling pathwaythrough preventing ubiquitination of beta-catenin CTNNB1 by thebeta-catenin destruction complex, thus negatively regulatingCTNNB1 degradation (PubMed:27098453). Serves as a scaffold tocoordinate PI3K/AKT pathway-driven cell growth and migration(PubMed:26895380). Protects cells from oxidative stress-inducedapoptosis via the down-regulation of AP-1 transcriptional activityas well as by inhibiting cytochrome c release from mitochondria(PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).{ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603,ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927,ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NVL_WDR26 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NVL_WDR26 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NVL | TTF2, CRMP1, OSGEP, SIRT7, CUL3, MOV10, RPL14, NPM1, PRR11, ILF2, HSPB1, IFI16, CEP164, CEP19, UBE2I, RHOA, CLCN2, HNRNPU, RPL10, UBA1, KIF21A, GPATCH4, RRP8, PES1, MAK16, ZNF512, PLEKHO1, FGF8, MECP2, RBM34, DGCR8, ZNF71, RBM4, PPAN | WDR26 | RAE1, CUL4B, CUL4A, WDR5, UBC, UBXN7, FAF2, FAF1, USP12, USP46, MAPK6, ARRB2, TSG101, GNB1, GNG2, RANBP10, ZNF131, UBE2O, ZNF687, BARD1, NPM1, SOX2, EGFR, GID8, PNO1, RANBP9, RPS15A, RPS24, RPS26, RPS6, RPS7, RPS8, TSR1, KIAA0368, KCMF1, PLCB2, MAGEA1, TDGF1, MRPL4, RMND5A, PRG2, EPB41L3, NTRK1, CNOT2, KIAA1107, SKI, AXIN1, NFATC2, BMP1, INSL6, PRICKLE3, PIP4K2A, CCDC120, IKZF1, JPH4, PRG3, TIGD5, PIGT, HTRA4, PTPN14, PTPN21, ARMC8, YPEL5, MAEA, UBE2H, HTRA2, RMND5B, GID4, MKLN1, NDUFAF4, NDUFA5, RAB8A, EFHC2, PIK3CB, AKT2, PIK3R1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NVL_WDR26 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NVL_WDR26 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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