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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25275

FusionGeneSummary for NUTF2_TSNAXIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUTF2_TSNAXIP1
Fusion gene ID: 25275
HgeneTgene
Gene symbol

NUTF2

TSNAXIP1

Gene ID

10204

55815

Gene namenuclear transport factor 2translin associated factor X interacting protein 1
SynonymsNTF-2|NTF2|PP15TXI1
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear transport factor 2placental protein 15translin-associated factor X-interacting protein 1trax-interacting protein 1
Modification date2018052320180519
UniProtAcc

P61970

Q2TAA8

Ensembl transtripts involved in fusion geneENST00000219169, ENST00000569436, 
ENST00000568396, 
ENST00000415766, 
ENST00000561639, ENST00000388833, 
ENST00000562321, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUTF2 [Title/Abstract] AND TSNAXIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUTF2

GO:0006606

protein import into nucleus

7744965|10679025

HgeneNUTF2

GO:0006611

protein export from nucleus

16449645


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5K2-01ANUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000219169ENST00000415766NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
5UTR-3CDSENST00000219169ENST00000561639NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
5UTR-3CDSENST00000219169ENST00000388833NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
5UTR-intronENST00000219169ENST00000562321NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000569436ENST00000415766NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000569436ENST00000561639NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000569436ENST00000388833NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-intronENST00000569436ENST00000562321NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000568396ENST00000415766NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000568396ENST00000561639NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-3CDSENST00000568396ENST00000388833NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+
intron-intronENST00000568396ENST00000562321NUTF2chr16

67880888

+TSNAXIP1chr16

67861152

+

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FusionProtFeatures for NUTF2_TSNAXIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUTF2

P61970

TSNAXIP1

Q2TAA8

Mediates the import of GDP-bound RAN from the cytoplasminto the nucleus which is essential for the function of RAN incargo receptor-mediated nucleocytoplasmic transport. Thereby,plays indirectly a more general role in cargo receptor-mediatednucleocytoplasmic transport. Interacts with GDP-bound RAN in thecytosol, recruits it to the nuclear pore complex via itsinteraction with nucleoporins and promotes its nuclear import.{ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}. Possible role in spermatogenesis.{ECO:0000250|UniProtKB:Q99P25}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUTF2_TSNAXIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUTF2_TSNAXIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUTF2NUP153, RAN, LUC7L2, NUP62, NUP54, KPNB1, NUTF2, ELAVL1, NXF1, SHMT2, MOV10, AP2A1, AP2A2, APOA1BP, CTH, GPX4, HINT1, FKBP2, KCNAB2, PGAM1, PGAM2, RAB11A, RAB11B, RPE, SCLY, SOD1, TAGLN, TAGLN2, TAGLN3, XPNPEP1, PRCP, RAB7A, RHOA, TANGO2, TRIM25TSNAXIP1APP, UBE2L3, HSPB1, PIBF1, CCDC186, DPP8, FBXW5, USO1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUTF2_TSNAXIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUTF2_TSNAXIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUTF2C0019693HIV Infections1CTD_human