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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25266

FusionGeneSummary for NUP98_RHOG

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_RHOG
Fusion gene ID: 25266
HgeneTgene
Gene symbol

NUP98

RHOG

Gene ID

4928

391

Gene namenucleoporin 98ras homolog family member G
SynonymsADIR2|NUP196|NUP96ARHG
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDarho-related GTP-binding protein RhoGras homolog gene family, member G (rho G)
Modification date2018052320180523
UniProtAcc

P52948

P84095

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000351018, ENST00000396979, 
ENST00000396978, ENST00000533217, 
Fusion gene scores* DoF score16 X 12 X 7=13444 X 3 X 3=36
# samples 214
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP98 [Title/Abstract] AND RHOG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRHOG

GO:0007266

Rho protein signal transduction

12376551

TgeneRHOG

GO:0016601

Rac protein signal transduction

12376551

TgeneRHOG

GO:0030036

actin cytoskeleton organization

12545154

TgeneRHOG

GO:0045893

positive regulation of transcription, DNA-templated

12545154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-DS-A1O9-01ANUP98chr11

3797112

-RHOGchr11

3849436

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000324932ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000324932ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000324932ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000324932ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000359171ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000359171ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000359171ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000359171ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000355260ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000355260ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000355260ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000355260ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397004ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397004ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397004ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397004ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397007ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397007ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397007ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
5CDS-5UTRENST00000397007ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-
intron-5UTRENST00000488828ENST00000351018NUP98chr11

3797112

-RHOGchr11

3849436

-
intron-5UTRENST00000488828ENST00000396979NUP98chr11

3797112

-RHOGchr11

3849436

-
intron-5UTRENST00000488828ENST00000396978NUP98chr11

3797112

-RHOGchr11

3849436

-
intron-5UTRENST00000488828ENST00000533217NUP98chr11

3797112

-RHOGchr11

3849436

-

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FusionProtFeatures for NUP98_RHOG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

RHOG

P84095

Required for the formation of membrane ruffles duringmacropinocytosis. Plays a role in cell migration and is requiredfor the formation of cup-like structures during trans-endothelialmigration of leukocytes. In case of Salmonella enterica infection,activated by SopB and ARHGEF26/SGEF, which induces cytoskeletonrearrangements and promotes bacterial entry.{ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883,ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP98_RHOG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP98_RHOG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, KPNB1, RAE1, TNPO2, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, SIRT7, NUP107, CTNNB1, RAPGEF3, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1RHOGARHGDIG, ELMOD2, DOCK1, KTN1, VAV3, MAP3K11, IQGAP2, ARHGDIA, FBXO6, TRIO, NT5E, RAB7A, ATP6AP2, ELMO1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP98_RHOG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP98_RHOG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human