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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25262

FusionGeneSummary for NUP98_PHF23

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_PHF23
Fusion gene ID: 25262
HgeneTgene
Gene symbol

NUP98

PHF23

Gene ID

4928

79142

Gene namenucleoporin 98PHD finger protein 23
SynonymsADIR2|NUP196|NUP96hJUNE-1b
Cytomap

11p15.4

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDaPHD finger protein 23PDH-containing protein JUNE-1PHD finger protein 23a
Modification date2018052320180523
UniProtAcc

P52948

Q9BUL5

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000320316, ENST00000571362, 
ENST00000576955, ENST00000454255, 
ENST00000570753, 
Fusion gene scores* DoF score16 X 12 X 7=13442 X 2 X 2=8
# samples 212
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: NUP98 [Title/Abstract] AND PHF23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EF071958NUP98chr11

3756420

-PHF23chr17

7139887

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000324932ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000324932ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000324932ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000324932ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-intronENST00000324932ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000359171ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000359171ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000359171ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000359171ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-intronENST00000359171ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000355260ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000355260ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000355260ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000355260ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-intronENST00000355260ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000397004ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000397004ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000397004ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000397004ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-intronENST00000397004ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000397007ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
Frame-shiftENST00000397007ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000397007ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-5UTRENST00000397007ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
5CDS-intronENST00000397007ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-
intron-3CDSENST00000488828ENST00000320316NUP98chr11

3756420

-PHF23chr17

7139887

-
intron-3CDSENST00000488828ENST00000571362NUP98chr11

3756420

-PHF23chr17

7139887

-
intron-5UTRENST00000488828ENST00000576955NUP98chr11

3756420

-PHF23chr17

7139887

-
intron-5UTRENST00000488828ENST00000454255NUP98chr11

3756420

-PHF23chr17

7139887

-
intron-intronENST00000488828ENST00000570753NUP98chr11

3756420

-PHF23chr17

7139887

-

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FusionProtFeatures for NUP98_PHF23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

PHF23

Q9BUL5

Acts as a negative regulator of autophagy, throughpromoting ubiquitination and degradation of LRSAM1, an E3ubiquitin ligase that promotes autophagy in response to starvationor infecting bacteria. {ECO:0000269|PubMed:25484098}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP98_PHF23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP98_PHF23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, KPNB1, RAE1, TNPO2, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, SIRT7, NUP107, CTNNB1, RAPGEF3, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1PHF23PRSS23, HCCS, LRSAM1, ERBB2, STK11, FOXK2, SIN3A, SAP130, ARID4B, SIN3B, SAP30, SUDS3, BRMS1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP98_PHF23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP98_PHF23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human