FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25261

FusionGeneSummary for NUP98_NUP98

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_NUP98
Fusion gene ID: 25261
HgeneTgene
Gene symbol

NUP98

NUP98

Gene ID

4928

4928

Gene namenucleoporin 98nucleoporin 98
SynonymsADIR2|NUP196|NUP96ADIR2|NUP196|NUP96
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDanuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDa
Modification date2018052320180523
UniProtAcc

P52948

P52948

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
Fusion gene scores* DoF score16 X 12 X 7=13449 X 9 X 5=405
# samples 2111
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP98 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA527634NUP98chr11

3759420

-NUP98chr11

3759452

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000324932ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000324932ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000324932ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000324932ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000324932ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000324932ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000359171ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000355260ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397004ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000397007ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000324932NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000359171NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000355260NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000397004NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000397007NUP98chr11

3759420

-NUP98chr11

3759452

+
intron-intronENST00000488828ENST00000488828NUP98chr11

3759420

-NUP98chr11

3759452

+

Top

FusionProtFeatures for NUP98_NUP98


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

NUP98

P52948


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NUP98_NUP98


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NUP98_NUP98


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NUP98_NUP98


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NUP98_NUP98


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human