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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25256

FusionGeneSummary for NUP98_HOXA9

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_HOXA9
Fusion gene ID: 25256
HgeneTgene
Gene symbol

NUP98

HOXA9

Gene ID

4928

3205

Gene namenucleoporin 98homeobox A9
SynonymsADIR2|NUP196|NUP96ABD-B|HOX1|HOX1.7|HOX1G
Cytomap

11p15.4

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDahomeobox protein Hox-A9homeobox protein Hox-1Ghomeodomain protein HOXA9
Modification date2018052320180519
UniProtAcc

P52948

P31269

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000343483, ENST00000497089, 
ENST00000396345, 
Fusion gene scores* DoF score16 X 12 X 7=13441 X 1 X 1=1
# samples 211
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NUP98 [Title/Abstract] AND HOXA9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U41814NUP98chr11

3765739

-HOXA9chr7

27204588

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000324932ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000324932ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000324932ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-
Frame-shiftENST00000359171ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000359171ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000359171ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-
Frame-shiftENST00000355260ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000355260ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000355260ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-
Frame-shiftENST00000397004ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000397004ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000397004ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-
Frame-shiftENST00000397007ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000397007ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
5CDS-intronENST00000397007ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-
intron-3CDSENST00000488828ENST00000343483NUP98chr11

3765739

-HOXA9chr7

27204588

-
intron-intronENST00000488828ENST00000497089NUP98chr11

3765739

-HOXA9chr7

27204588

-
intron-intronENST00000488828ENST00000396345NUP98chr11

3765739

-HOXA9chr7

27204588

-

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FusionProtFeatures for NUP98_HOXA9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

HOXA9

P31269

Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis.Required for induction of E-selectin and VCAM-1, on theendothelial cells surface at sites of inflammation.{ECO:0000269|PubMed:22269951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP98_HOXA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP98_HOXA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP98_HOXA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP98_HOXA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneHOXA9C0005695Bladder Neoplasm1CTD_human
TgeneHOXA9C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneHOXA9C0025202melanoma1CTD_human
TgeneHOXA9C0027643Neoplasm Recurrence, Local1CTD_human