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Fusion gene ID: 25245 |
FusionGeneSummary for NUP85_NR5A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP85_NR5A2 | Fusion gene ID: 25245 | Hgene | Tgene | Gene symbol | NUP85 | NR5A2 | Gene ID | 79902 | 2494 |
| Gene name | nucleoporin 85 | nuclear receptor subfamily 5 group A member 2 | |
| Synonyms | FROUNT|Nup75 | B1F|B1F2|CPF|FTF|FTZ-F1|FTZ-F1beta|LRH-1|LRH1|hB1F-2 | |
| Cytomap | 17q25.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85 | nuclear receptor subfamily 5 group A member 2CYP7A promoter-binding factorb1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virusfetoprotein-alpha 1 (AFP) transcription factorhepatocytic transcription factor | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9BW27 | O00482 | |
| Ensembl transtripts involved in fusion gene | ENST00000245544, ENST00000541827, ENST00000579324, ENST00000449421, ENST00000579298, ENST00000447371, ENST00000540768, | ENST00000367362, ENST00000236914, ENST00000544748, | |
| Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NUP85 [Title/Abstract] AND NR5A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR5A2 | GO:0006355 | regulation of transcription, DNA-templated | 15723037 |
| Tgene | NR5A2 | GO:0045070 | positive regulation of viral genome replication | 19264593 |
| Tgene | NR5A2 | GO:0045893 | positive regulation of transcription, DNA-templated | 15143342 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-NK-A5D1-01A | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000245544 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| In-frame | ENST00000245544 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| In-frame | ENST00000245544 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000541827 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000541827 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000541827 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000579324 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000579324 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000579324 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 3UTR-3CDS | ENST00000449421 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 3UTR-3CDS | ENST00000449421 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 3UTR-3CDS | ENST00000449421 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| In-frame | ENST00000579298 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| In-frame | ENST00000579298 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| In-frame | ENST00000579298 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000447371 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000447371 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| 5UTR-3CDS | ENST00000447371 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| intron-3CDS | ENST00000540768 | ENST00000367362 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| intron-3CDS | ENST00000540768 | ENST00000236914 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
| intron-3CDS | ENST00000540768 | ENST00000544748 | NUP85 | chr17 | 73201889 | + | NR5A2 | chr1 | 200080330 | + |
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FusionProtFeatures for NUP85_NR5A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP85 | NR5A2 |
| Essential component of the nuclear pore complex (NPC)that seems to be required for NPC assembly and maintenance(PubMed:12718872). As part of the NPC Nup107-160 subcomplex playsa role in RNA export and in tethering NUP96/Nup98 and NUP153 tothe nucleus (PubMed:12718872). The Nup107-160 complex seems to berequired for spindle assembly during mitosis (PubMed:16807356).NUP85 is required for membrane clustering of CCL2-activated CCR2(PubMed:15995708). Seems to be involved in CCR2-mediatedchemotaxis of monocytes and may link activated CCR2 to thephosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusioncascade (PubMed:15995708). {ECO:0000269|PubMed:12718872,ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}. | Nuclear receptor that acts as a key metabolic sensor byregulating the expression of genes involved in bile acidsynthesis, cholesterol homeostasis and triglyceride synthesis.Together with the oxysterol receptors NR1H3/LXR-alpha andNR1H2/LXR-beta, acts as an essential transcriptional regulator oflipid metabolism. Plays an anti-inflammatory role during thehepatic acute phase response by acting as a corepressor: inhibitsthe hepatic acute phase response by preventing dissociation of theN-Cor corepressor complex (PubMed:20159957). Binds to the sequenceelement 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis Bvirus genes, a critical cis-element of their expression andregulation. May be responsible for the liver-specific activity ofenhancer II, probably in combination with other hepatocytetranscription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contributeto the regulation of pancreas-specific genes and play importantroles in embryonic development. {ECO:0000269|PubMed:15707893,ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460,ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:20159957}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 419_424 | 324 | 496 | Region | Note=Lipid binding |
| Tgene | >NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 419_424 | 370 | 542 | Region | Note=Lipid binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 83_154 | 324 | 496 | DNA binding | Nuclear receptor |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 83_154 | 370 | 542 | DNA binding | Nuclear receptor |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 300_539 | 324 | 496 | Domain | NR LBD |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 300_539 | 370 | 542 | Domain | NR LBD |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 155_184 | 324 | 496 | Motif | Note=FTZ-F1 box |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 155_184 | 370 | 542 | Motif | Note=FTZ-F1 box |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 122_146 | 324 | 496 | Zinc finger | NR C4-type |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000236914 | + | 3 | 7 | 86_106 | 324 | 496 | Zinc finger | NR C4-type |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 122_146 | 370 | 542 | Zinc finger | NR C4-type |
| Tgene | NR5A2 | chr17:73201889 | chr1:200080330 | ENST00000367362 | + | 4 | 8 | 86_106 | 370 | 542 | Zinc finger | NR C4-type |
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FusionGeneSequence for NUP85_NR5A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_183aa MEELDGEPTVTVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_549nt ATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGAC CACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAA GCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTA TGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCC GCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATC AGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_3834nt GCTCTGAGCGGGAGGCCTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCG AGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGG TACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACA ACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGC TCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAA TGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAAT ACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCC CTAGGAGCTCTGCTTTCAAAACAAAAAGAGATTGGGGGAGTGGGGAGGGGGAAGAAGAACAGGAAGAAAAAAAGTACTCTGAACTGCTCC AAGTAACGCTAATTAAAAACTTGCTTTAAAGATATTGAATTTAAAAAGGCATAATAATCAAATACTTAATAGCAAATAAATGATGTATCA GGGTATTTGTATTGCAAACTGTGAATCAAAGGCTTCACAGCCCCAGAGGATTCCATATAAAAGACATTGTAATGGAGTGGATTGAACTCA CAGATGGATACCAACACGGTCAGAAGAAAAACGGACAGAACGGTTCTTGTATATTTAAACTGATCTCCACTATGAAGAAATTTAGGAACT AATCTTATTAATTAGGCTTATACAGCGGGGGATTTGAGCTTACAGGATTCCTCCATGGTAAAGCTGAACTGAAACAATTCTCAAGAATGC ATCAGCTGTACCTACAATAGCCCCTCCCTCTTCCTTTGAAGGCCCCAGCACCTCTGCCCTGTGGTCACCGAATCTGTACTAAGGACCTGT GTTCAGCCACACCCAGTGGTAGCTCCACCAAATCATGAACAGCCTAATTTTGAGTGTCTGTGTCTTAGACCTGCAAACAGCTAATAGGAA ATTCTATTAATATGTTAGCTTGCCATTTTAAATATGTTCTGAGGGTTGTTTTGTCTCGTGTTCATGATGTTAAGAAAATGCAGGCAGTAT CCCTCATCTTATGTAAGTGTTAATTAATATTAAGGGAAATGACTACAAACTTTCAAAGCAAATGCTCCATAGCTAAAGCAACTTAGACCT TATTTCTGCTACTGTTGCTGAAATGTGGCTTTGGCATTGTTGGATTTCATAAAAAATTTCTGGCAGGAAGTCTTGTTAGTATACATCAGT CTTTTTCATCATCCAAGTTTGTAGTTCATTTAAAAATACAACATTAAACACATTTTGCTAGGATGTCAAATAGTCACAGTTCTAAGTAGT TGGAAACAAAATTGACGCATGTTAATCTATGCAAAGAGAAAGGAAAGGATGAGGTGATGTATTGACTCAAGGTTCATTCTTGCTGCAATT GAACATCCTCAAGAGTTGGGATGGAAATGGTGATTTTTACATGTGTCCTGGAAAGATATTAAAGTAATTCAAATCTTCCCCAAAGGGGAA AGGAAGAGAGTGATACTGACCTTTTTAAGTCATAGACCAAAGTCTGCTGTAGAACAAATATGGGAGGACAAAGAATCGCAAATTCTTCAA ATGACTATTATCAGTATTATTAACATGCGATGCCACAGGTATGAAAGTCTTGCCTTATTTCACAATTTTAAAAGGTAGCTGTGCAGATGT GGATCAACATTTGTTTAAAATAAAGTATTAATACTTTAAAGTCAAATAAGATATAGTGTTTACATTCTTTAGGTCCTGAGGGGCAGGGGG ATCTGTGATATAACAAAATAGCAAAAGCGGTAATTTCCTTAATGTTATTTTTCTGATTGGTAATTATTTTTAACAGTACTTAATTATTCT ATGTCGTGAGACACTAAAATCAAAAACGGGAATCTCATTTAGACTTTAATTTTTTTGAGATTATCGGCGGCACAATCACTTTGTAGAAAC TGTAAAAAATAAAAGTATCTCCTAGTCCCTTAATTTTTTCATAAATATTTCTGGCTTTTGAGTAGTGTATTTATATTGTATATCATACTT TCAACTGTAGACAATTATGATGCTAATTTATTGTTTCTTGGTTTCACCTTTGTATAAGATATAGCCAAGACTGAAGAAACCAAATATATG TGTTTACTGTAGCATGTCTTCAAATTAGTGGAACTTAGTTCAGGGACATAGAAGAGTCTTAATGAATTAAAATCATTCACTTGATTAAAT GTCTGTAAATCTTCATCATTCCTACTGTAGTTTATTTAATATCTATTGTAAATTATGTGACTTGTAGCTTCCTCTGGTTTTCAAGTAAAC TCAACAAGGTGGAGTCTTACCTGGTTTTCCTTTCCAAGCATTGTAAATTGTATACCAAAGATATTAGTTATTACTTCTGTGTGTACAAAG AGGATTATTTTATTATGTTTATTAATCACCTCTAATACTCATCCACATGAAGGGTACACATTAGGTAAGCTGGGCGTTGACTCATGCGCA GTCTCAGTCACCCGTGTTATCTTCGTGGCTCAAAGGACAATGCAAAATCGCCGATCAGAGCTCATACCCAAAGCATTACAGAGAACAGCA GCATCATTGCCCTCCCCAGCTGAAAAACAAGTTGGCTAGAAGATACATGGAGAGGAATGGTGTGGTCAACAGTTAATGAAACGGTTCTAT CATGCATGTGTAATGTGGATGGAGACAATTATAAGATTTGACTATAACTATTTGGAGGGTCTTTAACATTGCCAAAAAAACAAATATGTT GATTTTTATTTTATTTTATTTTTTATTTTAAGAGGCGGGATCTTGATCTCACATGTTGCCCAGGCTGGCCTTGAACTCCTGGGCTCAAGC ATTCCTCCTGCCTCAGCCTCCCCCATAGCTGGGACTAGGGGTGCATGCCAGCATACCTGGCTACGTTGACTCTTAAAATCTATGTTCTCT TATTTTAAAGATACAGTGCTCCCCACTGAAAATTAAACCTAAAAAATGTCACATATTGGTATGTTGTTAACCTGGTAGATTAAATCATGA GAATGATTAGAAAGACGGGCAACACAGCGGGTTACATCCACACTGCTGATCACACCAACGACAGGAGCTGATAAGCAAGAAAGCGTCACA GCCAGCGTCTGTTCACCCAAGGTTGACAAGTGAAGTTTCTCTAATGTTGATTGTTAGCCGATTTGTAACCTGGCATTTACTTAGCAACTG CCTTATCAATTACAGGATTTGCCGGTAAAAGCAGACTCAAATATAAAGGTTTTTGGCTTAACTTGGTTTATTATAGTTGCTCTATGTTTG TAAACAGACAATCTCTAATGTCTGATTATTTGTATCACAGATCTGCAGCTGCCTTGGACTTGAATCCATGCAATGTTTAGAGTGTGAAGT CAGTTACTTGTTGATGTTTTCTTACTGTATCAATGAAATACATATTGTCATGTCAGTTCTTGCCAGGAACTTCTCAACAAAATGGAATTT >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_2013nt GCTCTGAGCGGGAGGCCTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCG AGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGG TACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACA ACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGC TCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAA TGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAAT ACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCC CTAGGAGCTCTGCTTTCAAAACAAAAAGAGATTGGGGGAGTGGGGAGGGGGAAGAAGAACAGGAAGAAAAAAAGTACTCTGAACTGCTCC AAGTAACGCTAATTAAAAACTTGCTTTAAAGATATTGAATTTAAAAAGGCATAATAATCAAATACTTAATAGCAAATAAATGATGTATCA GGGTATTTGTATTGCAAACTGTGAATCAAAGGCTTCACAGCCCCAGAGGATTCCATATAAAAGACATTGTAATGGAGTGGATTGAACTCA CAGATGGATACCAACACGGTCAGAAGAAAAACGGACAGAACGGTTCTTGTATATTTAAACTGATCTCCACTATGAAGAAATTTAGGAACT AATCTTATTAATTAGGCTTATACAGCGGGGGATTTGAGCTTACAGGATTCCTCCATGGTAAAGCTGAACTGAAACAATTCTCAAGAATGC ATCAGCTGTACCTACAATAGCCCCTCCCTCTTCCTTTGAAGGCCCCAGCACCTCTGCCCTGTGGTCACCGAATCTGTACTAAGGACCTGT GTTCAGCCACACCCAGTGGTAGCTCCACCAAATCATGAACAGCCTAATTTTGAGTGTCTGTGTCTTAGACCTGCAAACAGCTAATAGGAA ATTCTATTAATATGTTAGCTTGCCATTTTAAATATGTTCTGAGGGTTGTTTTGTCTCGTGTTCATGATGTTAAGAAAATGCAGGCAGTAT CCCTCATCTTATGTAAGTGTTAATTAATATTAAGGGAAATGACTACAAACTTTCAAAGCAAATGCTCCATAGCTAAAGCAACTTAGACCT TATTTCTGCTACTGTTGCTGAAATGTGGCTTTGGCATTGTTGGATTTCATAAAAAATTTCTGGCAGGAAGTCTTGTTAGTATACATCAGT CTTTTTCATCATCCAAGTTTGTAGTTCATTTAAAAATACAACATTAAACACATTTTGCTAGGATGTCAAATAGTCACAGTTCTAAGTAGT TGGAAACAAAATTGACGCATGTTAATCTATGCAAAGAGAAAGGAAAGGATGAGGTGATGTATTGACTCAAGGTTCATTCTTGCTGCAATT GAACATCCTCAAGAGTTGGGATGGAAATGGTGATTTTTACATGTGTCCTGGAAAGATATTAAAGTAATTCAAATCTTCCCCAAAGGGGAA AGGAAGAGAGTGATACTGACCTTTTTAAGTCATAGACCAAAGTCTGCTGTAGAACAAATATGGGAGGACAAAGAATCGCAAATTCTTCAA ATGACTATTATCAGTATTATTAACATGCGATGCCACAGGTATGAAAGTCTTGCCTTATTTCACAATTTTAAAAGGTAGCTGTGCAGATGT >In-frame_NUP85_ENST00000245544_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_671nt GCTCTGAGCGGGAGGCCTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCG AGCCAACAGTCACTGTTGATGACCAAATGAAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGG TACATGGAAAGGAAGGATCCATCTTCCTGGTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACA ACCTCATGAGTCATGCACAGGAGTTAGTGGCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGC TCTTTAGTTTAGATGTCAAAAACCTTGAAAACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAA TGTGTAACTACCCGCAGCAGACAGAGAAATTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAAT ACCTCTACTACAAGCACCTGAACGGGGATGTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCC >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000367362_chr1_200080330_+_3805nt ATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATG AAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTG GTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTG GCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAA AACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAA TTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGAT GTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCCCTAGGAGCTCTGCTTTCAAAACAAAAAGA GATTGGGGGAGTGGGGAGGGGGAAGAAGAACAGGAAGAAAAAAAGTACTCTGAACTGCTCCAAGTAACGCTAATTAAAAACTTGCTTTAA AGATATTGAATTTAAAAAGGCATAATAATCAAATACTTAATAGCAAATAAATGATGTATCAGGGTATTTGTATTGCAAACTGTGAATCAA AGGCTTCACAGCCCCAGAGGATTCCATATAAAAGACATTGTAATGGAGTGGATTGAACTCACAGATGGATACCAACACGGTCAGAAGAAA AACGGACAGAACGGTTCTTGTATATTTAAACTGATCTCCACTATGAAGAAATTTAGGAACTAATCTTATTAATTAGGCTTATACAGCGGG GGATTTGAGCTTACAGGATTCCTCCATGGTAAAGCTGAACTGAAACAATTCTCAAGAATGCATCAGCTGTACCTACAATAGCCCCTCCCT CTTCCTTTGAAGGCCCCAGCACCTCTGCCCTGTGGTCACCGAATCTGTACTAAGGACCTGTGTTCAGCCACACCCAGTGGTAGCTCCACC AAATCATGAACAGCCTAATTTTGAGTGTCTGTGTCTTAGACCTGCAAACAGCTAATAGGAAATTCTATTAATATGTTAGCTTGCCATTTT AAATATGTTCTGAGGGTTGTTTTGTCTCGTGTTCATGATGTTAAGAAAATGCAGGCAGTATCCCTCATCTTATGTAAGTGTTAATTAATA TTAAGGGAAATGACTACAAACTTTCAAAGCAAATGCTCCATAGCTAAAGCAACTTAGACCTTATTTCTGCTACTGTTGCTGAAATGTGGC TTTGGCATTGTTGGATTTCATAAAAAATTTCTGGCAGGAAGTCTTGTTAGTATACATCAGTCTTTTTCATCATCCAAGTTTGTAGTTCAT TTAAAAATACAACATTAAACACATTTTGCTAGGATGTCAAATAGTCACAGTTCTAAGTAGTTGGAAACAAAATTGACGCATGTTAATCTA TGCAAAGAGAAAGGAAAGGATGAGGTGATGTATTGACTCAAGGTTCATTCTTGCTGCAATTGAACATCCTCAAGAGTTGGGATGGAAATG GTGATTTTTACATGTGTCCTGGAAAGATATTAAAGTAATTCAAATCTTCCCCAAAGGGGAAAGGAAGAGAGTGATACTGACCTTTTTAAG TCATAGACCAAAGTCTGCTGTAGAACAAATATGGGAGGACAAAGAATCGCAAATTCTTCAAATGACTATTATCAGTATTATTAACATGCG ATGCCACAGGTATGAAAGTCTTGCCTTATTTCACAATTTTAAAAGGTAGCTGTGCAGATGTGGATCAACATTTGTTTAAAATAAAGTATT AATACTTTAAAGTCAAATAAGATATAGTGTTTACATTCTTTAGGTCCTGAGGGGCAGGGGGATCTGTGATATAACAAAATAGCAAAAGCG GTAATTTCCTTAATGTTATTTTTCTGATTGGTAATTATTTTTAACAGTACTTAATTATTCTATGTCGTGAGACACTAAAATCAAAAACGG GAATCTCATTTAGACTTTAATTTTTTTGAGATTATCGGCGGCACAATCACTTTGTAGAAACTGTAAAAAATAAAAGTATCTCCTAGTCCC TTAATTTTTTCATAAATATTTCTGGCTTTTGAGTAGTGTATTTATATTGTATATCATACTTTCAACTGTAGACAATTATGATGCTAATTT ATTGTTTCTTGGTTTCACCTTTGTATAAGATATAGCCAAGACTGAAGAAACCAAATATATGTGTTTACTGTAGCATGTCTTCAAATTAGT GGAACTTAGTTCAGGGACATAGAAGAGTCTTAATGAATTAAAATCATTCACTTGATTAAATGTCTGTAAATCTTCATCATTCCTACTGTA GTTTATTTAATATCTATTGTAAATTATGTGACTTGTAGCTTCCTCTGGTTTTCAAGTAAACTCAACAAGGTGGAGTCTTACCTGGTTTTC CTTTCCAAGCATTGTAAATTGTATACCAAAGATATTAGTTATTACTTCTGTGTGTACAAAGAGGATTATTTTATTATGTTTATTAATCAC CTCTAATACTCATCCACATGAAGGGTACACATTAGGTAAGCTGGGCGTTGACTCATGCGCAGTCTCAGTCACCCGTGTTATCTTCGTGGC TCAAAGGACAATGCAAAATCGCCGATCAGAGCTCATACCCAAAGCATTACAGAGAACAGCAGCATCATTGCCCTCCCCAGCTGAAAAACA AGTTGGCTAGAAGATACATGGAGAGGAATGGTGTGGTCAACAGTTAATGAAACGGTTCTATCATGCATGTGTAATGTGGATGGAGACAAT TATAAGATTTGACTATAACTATTTGGAGGGTCTTTAACATTGCCAAAAAAACAAATATGTTGATTTTTATTTTATTTTATTTTTTATTTT AAGAGGCGGGATCTTGATCTCACATGTTGCCCAGGCTGGCCTTGAACTCCTGGGCTCAAGCATTCCTCCTGCCTCAGCCTCCCCCATAGC TGGGACTAGGGGTGCATGCCAGCATACCTGGCTACGTTGACTCTTAAAATCTATGTTCTCTTATTTTAAAGATACAGTGCTCCCCACTGA AAATTAAACCTAAAAAATGTCACATATTGGTATGTTGTTAACCTGGTAGATTAAATCATGAGAATGATTAGAAAGACGGGCAACACAGCG GGTTACATCCACACTGCTGATCACACCAACGACAGGAGCTGATAAGCAAGAAAGCGTCACAGCCAGCGTCTGTTCACCCAAGGTTGACAA GTGAAGTTTCTCTAATGTTGATTGTTAGCCGATTTGTAACCTGGCATTTACTTAGCAACTGCCTTATCAATTACAGGATTTGCCGGTAAA AGCAGACTCAAATATAAAGGTTTTTGGCTTAACTTGGTTTATTATAGTTGCTCTATGTTTGTAAACAGACAATCTCTAATGTCTGATTAT TTGTATCACAGATCTGCAGCTGCCTTGGACTTGAATCCATGCAATGTTTAGAGTGTGAAGTCAGTTACTTGTTGATGTTTTCTTACTGTA TCAATGAAATACATATTGTCATGTCAGTTCTTGCCAGGAACTTCTCAACAAAATGGAATTTTTTTTTTCAGTATTTCAATAAATATTGAT >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000236914_chr1_200080330_+_1984nt ATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATG AAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTG GTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTG GCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAA AACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAA TTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGAT GTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCCCTAGGAGCTCTGCTTTCAAAACAAAAAGA GATTGGGGGAGTGGGGAGGGGGAAGAAGAACAGGAAGAAAAAAAGTACTCTGAACTGCTCCAAGTAACGCTAATTAAAAACTTGCTTTAA AGATATTGAATTTAAAAAGGCATAATAATCAAATACTTAATAGCAAATAAATGATGTATCAGGGTATTTGTATTGCAAACTGTGAATCAA AGGCTTCACAGCCCCAGAGGATTCCATATAAAAGACATTGTAATGGAGTGGATTGAACTCACAGATGGATACCAACACGGTCAGAAGAAA AACGGACAGAACGGTTCTTGTATATTTAAACTGATCTCCACTATGAAGAAATTTAGGAACTAATCTTATTAATTAGGCTTATACAGCGGG GGATTTGAGCTTACAGGATTCCTCCATGGTAAAGCTGAACTGAAACAATTCTCAAGAATGCATCAGCTGTACCTACAATAGCCCCTCCCT CTTCCTTTGAAGGCCCCAGCACCTCTGCCCTGTGGTCACCGAATCTGTACTAAGGACCTGTGTTCAGCCACACCCAGTGGTAGCTCCACC AAATCATGAACAGCCTAATTTTGAGTGTCTGTGTCTTAGACCTGCAAACAGCTAATAGGAAATTCTATTAATATGTTAGCTTGCCATTTT AAATATGTTCTGAGGGTTGTTTTGTCTCGTGTTCATGATGTTAAGAAAATGCAGGCAGTATCCCTCATCTTATGTAAGTGTTAATTAATA TTAAGGGAAATGACTACAAACTTTCAAAGCAAATGCTCCATAGCTAAAGCAACTTAGACCTTATTTCTGCTACTGTTGCTGAAATGTGGC TTTGGCATTGTTGGATTTCATAAAAAATTTCTGGCAGGAAGTCTTGTTAGTATACATCAGTCTTTTTCATCATCCAAGTTTGTAGTTCAT TTAAAAATACAACATTAAACACATTTTGCTAGGATGTCAAATAGTCACAGTTCTAAGTAGTTGGAAACAAAATTGACGCATGTTAATCTA TGCAAAGAGAAAGGAAAGGATGAGGTGATGTATTGACTCAAGGTTCATTCTTGCTGCAATTGAACATCCTCAAGAGTTGGGATGGAAATG GTGATTTTTACATGTGTCCTGGAAAGATATTAAAGTAATTCAAATCTTCCCCAAAGGGGAAAGGAAGAGAGTGATACTGACCTTTTTAAG TCATAGACCAAAGTCTGCTGTAGAACAAATATGGGAGGACAAAGAATCGCAAATTCTTCAAATGACTATTATCAGTATTATTAACATGCG ATGCCACAGGTATGAAAGTCTTGCCTTATTTCACAATTTTAAAAGGTAGCTGTGCAGATGTGGATCAACATTTGTTTAAAATAAAGTATT >In-frame_NUP85_ENST00000579298_chr17_73201889_+_NR5A2_ENST00000544748_chr1_200080330_+_642nt ATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTGTTGATGACCAAATG AAGCTGCTTCAGAACTGCTGGAGTGAGCTCTTAATCCTCGACCACATTTACCGACAAGTGGTACATGGAAAGGAAGGATCCATCTTCCTG GTTACTGGGCAACAAGTGGACTATTCCATAATAGCATCACAAGCCGGAGCCACCCTCAACAACCTCATGAGTCATGCACAGGAGTTAGTG GCAAAACTTCGTTCTCTCCAGTTTGATCAACGAGAGTTCGTATGTCTGAAATTCTTGGTGCTCTTTAGTTTAGATGTCAAAAACCTTGAA AACTTCCAGCTGGTAGAAGGTGTCCAGGAACAAGTCAATGCCGCCCTGCTGGACTACACAATGTGTAACTACCCGCAGCAGACAGAGAAA TTTGGACAGCTACTTCTTCGACTACCCGAAATCCGGGCCATCAGTATGCAGGCTGAAGAATACCTCTACTACAAGCACCTGAACGGGGAT GTGCCCTATAATAACCTTCTCATTGAAATGTTGCATGCCAAAAGAGCATAAGTTACAACCCCTAGGAGCTCTGCTTTCAAAACAAAAAGA |
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FusionGenePPI for NUP85_NR5A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP85 | SEH1L, NUP107, NUP43, NUP37, SEC13, EEF1G, USP36, USP49, HDAC11, EGFR, FBXO6, DCTN3, GBF1, RABL6, OBSL1, EED, CCDC183, CD274, TNFSF13B, CA14, PNKD, ENPP6, TGOLN2, NUP160, NUP98, NTRK1, IFI16, PRKDC, UNC45A, FMN1, KPNB1, ZNF740, POM121, HSP90AB1, NUDC, NUP88, RANGAP1, NUP62, NUP214, RANBP2, NUP50, NUP153, B9D2, UBE2I, FOXQ1, FAF2, UXS1, VASN, CD70, SPAST, ZNF785 | NR5A2 | EDF1, NR0B2, NCOA3, PPARGC1A, ALB, FTH1, NRIP1, BCKDK, NPPA, PNRC1, PNRC2, ILF3, GPS2, RAD54L2, UBE2I, CREB1, NSD1, NCOA1, NR1I2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP85_NR5A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP85_NR5A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NR5A2 | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
| Tgene | NR5A2 | C0003128 | Anovulation | 1 | CTD_human |
| Tgene | NR5A2 | C0021361 | Female infertility | 1 | CTD_human |
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