|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 25238 |
FusionGeneSummary for NUP62_DYRK1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP62_DYRK1B | Fusion gene ID: 25238 | Hgene | Tgene | Gene symbol | NUP62 | DYRK1B | Gene ID | 23636 | 9149 |
| Gene name | nucleoporin 62 | dual specificity tyrosine phosphorylation regulated kinase 1B | |
| Synonyms | IBSN|SNDI|p62 | AOMS3|MIRK | |
| Cytomap | 19q13.33 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore glycoprotein p6262 kDa nucleoporinnucleoporin 62kDnucleoporin 62kDanucleoporin Nup62 | dual specificity tyrosine-phosphorylation-regulated kinase 1Bdual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Bminibrain-related kinasemirk protein kinase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P37198 | Q9Y463 | |
| Ensembl transtripts involved in fusion gene | ENST00000422090, ENST00000413454, ENST00000352066, ENST00000597029, ENST00000597723, ENST00000596217, ENST00000600583, | ENST00000593685, ENST00000323039, ENST00000348817, ENST00000597639, ENST00000430012, ENST00000601972, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 3 X 1 X 2=6 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/60*10)=0 | log2(2/6*10)=1.73696559416621 | |
| Context | PubMed: NUP62 [Title/Abstract] AND DYRK1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUP62 | GO:0006351 | transcription, DNA-templated | 10373430 |
| Hgene | NUP62 | GO:0007166 | cell surface receptor signaling pathway | 10799545 |
| Hgene | NUP62 | GO:0008285 | negative regulation of cell proliferation | 11013214 |
| Hgene | NUP62 | GO:0043066 | negative regulation of apoptotic process | 11755531 |
| Hgene | NUP62 | GO:0043069 | negative regulation of programmed cell death | 11244088 |
| Hgene | NUP62 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 10356400 |
| Hgene | NUP62 | GO:0045893 | positive regulation of transcription, DNA-templated | 15625236 |
| Tgene | DYRK1B | GO:0006468 | protein phosphorylation | 11980910 |
| Tgene | DYRK1B | GO:0045893 | positive regulation of transcription, DNA-templated | 11980910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-JY-A6FD-01A | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000422090 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000422090 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000422090 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-intron | ENST00000422090 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000422090 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000422090 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000413454 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000413454 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000413454 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-intron | ENST00000413454 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000413454 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| intron-5UTR | ENST00000413454 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000352066 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000352066 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000352066 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-intron | ENST00000352066 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000352066 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000352066 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597029 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597029 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597029 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-intron | ENST00000597029 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597029 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597029 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597723 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597723 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597723 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-intron | ENST00000597723 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597723 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000597723 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000596217 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000596217 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000596217 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-intron | ENST00000596217 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000596217 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000596217 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000600583 | ENST00000593685 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000600583 | ENST00000323039 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000600583 | ENST00000348817 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-intron | ENST00000600583 | ENST00000597639 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000600583 | ENST00000430012 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
| 5UTR-5UTR | ENST00000600583 | ENST00000601972 | NUP62 | chr19 | 50430951 | - | DYRK1B | chr19 | 40322608 | - |
Top |
FusionProtFeatures for NUP62_DYRK1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP62 | DYRK1B |
| Essential component of the nuclear pore complex(PubMed:1915414). The N-terminal is probably involved innucleocytoplasmic transport (PubMed:1915414). The C-terminal isinvolved in protein-protein interaction probably via coiled-coilformation, promotes its association with centrosomes and mayfunction in anchorage of p62 to the pore complex (PubMed:1915414,PubMed:24107630). Plays a role in mitotic cell cycle progressionby regulating centrosome segregation, centriole maturation andspindle orientation (PubMed:24107630). It might be involved inprotein recruitment to the centrosome after nuclear breakdown(PubMed:24107630). {ECO:0000269|PubMed:1915414,ECO:0000269|PubMed:24107630}. | Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. Enhances thetranscriptional activity of TCF1/HNF1A and FOXO1. Inhibitsepithelial cell migration. Mediates colon carcinoma cell survivalin mitogen-poor environments. Inhibits the SHH and WNT1 pathways,thereby enhancing adipogenesis. In addition, promotes expressionof the gluconeogenic enzyme glucose-6-phosphatase (G6PC).{ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910,ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NUP62_DYRK1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NUP62_DYRK1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP62 | NUP54, DTNB, XPO6, CCDC53, THAP1, GORASP2, IK, NUTF2, KPNA1, XPO1, KPNB1, NXF2, TRAF3, HSF2, G3BP1, G3BP2, RAE1, OGT, ATXN7, PCK1, CTNNB1, CUL3, CUL5, EIF4A3, MOGS, DTNA, FUBP3, HEATR5A, EEF2, NPM1, VCP, ARFGEF1, NCL, NXF1, MUC1, SP1, NUP93, CLIC1, GOPC, DGCR6, CEP250, BFSP1, FABP3, KIFC3, KPNA2, LMO2, PIN1, SMARCE1, ADAM15, NUPL1, ABI2, SNAPC5, OIP5, ISCU, BLOC1S6, PHF21A, KRT20, CCHCR1, CRCT1, CCDC146, CCDC121, CENPU, MYO15B, IFT20, KLHL32, HAUS1, IKBIP, C1orf216, AGR3, TXLNA, CCDC153, KANSL1, SSC5D, CCDC150, CEP57L1, OBSL1, RANBP2, NUP214, NUP153, NUP62, DDX19A, ACOX1, MCM3, NUP88, IFI16, NUP85, NUP35, HSPB11, HSPA5, NUP107, MCM2, RAN, CPNE2, PDHA1, IDH1 | DYRK1B | DCAF7, RANBP9, MAPK1, MAPK14, PCBD1, PAK1, HDAC5, HIPK2, MAP3K1, HSP90AA1, RBL1, RB1, LZTS2, TROAP, CDKN2A, AKAP11, PRKAR1A, RBL2, CREBBP, EP300, SKI, FAM117B, GLCCI1, FAM53C, FAM117A, RNF169, DYNLL1, ABCD3, SIPA1L1, WDR6, ATAD3B, SIPA1L3, SIPA1L2, ICE1, KIAA0232, ZNF516, ENAH, LZTS3, PTGES3, DDB1, MSL3, ICE2, KAT8, FOXK1, ARNTL, CCNA2, EP400, CTBP2, TCEAL1, PRKACA, PPP1R3F, TECR, KPNB1, STUB1, USP11, MED23, ID2, DYRK1B, EGLN2, C10orf71, MISP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NUP62_DYRK1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NUP62_DYRK1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUP62 | C0795996 | STRIATONIGRAL DEGENERATION, INFANTILE (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | DYRK1B | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | DYRK1B | C4014361 | ABDOMINAL OBESITY-METABOLIC SYNDROME 3 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|