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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25228

FusionGeneSummary for NUP214_SEC14L2

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP214_SEC14L2
Fusion gene ID: 25228
HgeneTgene
Gene symbol

NUP214

SEC14L2

Gene ID

8021

23541

Gene namenucleoporin 214SEC14 like lipid binding 2
SynonymsCAIN|CANC22orf6|SPF|TAP|TAP1
Cytomap

9q34.13

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDaSEC14-like protein 2alpha-tocopherol-associated proteinsqualene transfer proteinsupernatant protein factortocopherol-associated protein 1
Modification date2018052320180519
UniProtAcc

P35658

O76054

Ensembl transtripts involved in fusion geneENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 
ENST00000312932, 
ENST00000403484, ENST00000405717, 
ENST00000402592, ENST00000459728, 
Fusion gene scores* DoF score11 X 11 X 4=4844 X 4 X 4=64
# samples 114
** MAII scorelog2(11/484*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP214 [Title/Abstract] AND SEC14L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0901-01BNUP214chr9

134010613

+SEC14L2chr22

30818284

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359428ENST00000312932NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000359428ENST00000403484NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000359428ENST00000405717NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000359428ENST00000402592NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000359428ENST00000459728NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000411637ENST00000312932NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000411637ENST00000403484NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000411637ENST00000405717NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000411637ENST00000402592NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000411637ENST00000459728NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000451030ENST00000312932NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000451030ENST00000403484NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000451030ENST00000405717NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000451030ENST00000402592NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000451030ENST00000459728NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000483497ENST00000312932NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000483497ENST00000403484NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000483497ENST00000405717NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000483497ENST00000402592NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000483497ENST00000459728NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000465486ENST00000312932NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-3CDSENST00000465486ENST00000403484NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000465486ENST00000405717NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000465486ENST00000402592NUP214chr9

134010613

+SEC14L2chr22

30818284

+
intron-intronENST00000465486ENST00000459728NUP214chr9

134010613

+SEC14L2chr22

30818284

+

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FusionProtFeatures for NUP214_SEC14L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

SEC14L2

O76054

May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}. Carrier protein. Binds to some hydrophobic molecules andpromotes their transfer between the different cellular sites.Binds with high affinity to alpha-tocopherol. Also binds with aweaker affinity to other tocopherols and to tocotrienols. May havea transcriptional activatory activity via its association withalpha-tocopherol. Probably recognizes and binds some squalenestructure, suggesting that it may regulate cholesterolbiosynthesis by increasing the transfer of squalene to a metabolicactive pool in the cell.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP214_SEC14L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP214_SEC14L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, NUPL2, NUP214, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1SEC14L2SEC14L3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP214_SEC14L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP214_SEC14L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource