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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25227

FusionGeneSummary for NUP214_NUP214

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP214_NUP214
Fusion gene ID: 25227
HgeneTgene
Gene symbol

NUP214

NUP214

Gene ID

8021

8021

Gene namenucleoporin 214nucleoporin 214
SynonymsCAIN|CANCAIN|CAN
Cytomap

9q34.13

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDanuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2018052320180523
UniProtAcc

P35658

P35658

Ensembl transtripts involved in fusion geneENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 		ENST00000359428, 
ENST00000411637, ENST00000451030, 
ENST00000483497, ENST00000465486, 
Fusion gene scores* DoF score11 X 11 X 4=4846 X 7 X 4=168
# samples 117
** MAII scorelog2(11/484*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP214 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ329628NUP214chr9

134039450

-NUP214chr9

134039254

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359428ENST00000359428NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000359428ENST00000411637NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000359428ENST00000451030NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000359428ENST00000483497NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000359428ENST00000465486NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000411637ENST00000359428NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000411637ENST00000411637NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000411637ENST00000451030NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000411637ENST00000483497NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000411637ENST00000465486NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000451030ENST00000359428NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000451030ENST00000411637NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000451030ENST00000451030NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000451030ENST00000483497NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000451030ENST00000465486NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000483497ENST00000359428NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000483497ENST00000411637NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000483497ENST00000451030NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000483497ENST00000483497NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000483497ENST00000465486NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000465486ENST00000359428NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000465486ENST00000411637NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-3CDSENST00000465486ENST00000451030NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000465486ENST00000483497NUP214chr9

134039450

-NUP214chr9

134039254

+
intron-intronENST00000465486ENST00000465486NUP214chr9

134039450

-NUP214chr9

134039254

+

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FusionProtFeatures for NUP214_NUP214


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

NUP214

P35658

May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}. May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP214_NUP214


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP214_NUP214


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP214_NUP214


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP214_NUP214


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource