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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25222

FusionGeneSummary for NUP214_AIF1L

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP214_AIF1L
Fusion gene ID: 25222
HgeneTgene
Gene symbol

NUP214

AIF1L

Gene ID

8021

83543

Gene namenucleoporin 214allograft inflammatory factor 1 like
SynonymsCAIN|CANC9orf58|IBA2
Cytomap

9q34.13

9q34.12-q34.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDaallograft inflammatory factor 1-likeionized calcium binding adapter molecule 2
Modification date2018052320180523
UniProtAcc

P35658

Q9BQI0

Ensembl transtripts involved in fusion geneENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 		ENST00000372309, 
ENST00000372302, ENST00000247291, 
ENST00000372300, ENST00000472942, 
ENST00000372298, ENST00000372297, 
ENST00000372312, ENST00000372301, 
Fusion gene scores* DoF score11 X 11 X 4=4842 X 2 X 2=8
# samples 112
** MAII scorelog2(11/484*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NUP214 [Title/Abstract] AND AIF1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A22G-01ANUP214chr9

134006223

+AIF1Lchr9

133986984

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359428ENST00000372309NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000359428ENST00000372302NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000359428ENST00000247291NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000359428ENST00000372300NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000359428ENST00000472942NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000359428ENST00000372298NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000359428ENST00000372297NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000359428ENST00000372312NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000359428ENST00000372301NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000411637ENST00000372309NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000411637ENST00000372302NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000411637ENST00000247291NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000411637ENST00000372300NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000411637ENST00000472942NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000411637ENST00000372298NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000411637ENST00000372297NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000411637ENST00000372312NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000411637ENST00000372301NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000451030ENST00000372309NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000451030ENST00000372302NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000451030ENST00000247291NUP214chr9

134006223

+AIF1Lchr9

133986984

+
In-frameENST00000451030ENST00000372300NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000451030ENST00000472942NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-3UTRENST00000451030ENST00000372298NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000451030ENST00000372297NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000451030ENST00000372312NUP214chr9

134006223

+AIF1Lchr9

133986984

+
5CDS-5UTRENST00000451030ENST00000372301NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000483497ENST00000372309NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000483497ENST00000372302NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000483497ENST00000247291NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000483497ENST00000372300NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3UTRENST00000483497ENST00000472942NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3UTRENST00000483497ENST00000372298NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000483497ENST00000372297NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000483497ENST00000372312NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000483497ENST00000372301NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000465486ENST00000372309NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000465486ENST00000372302NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000465486ENST00000247291NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3CDSENST00000465486ENST00000372300NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3UTRENST00000465486ENST00000472942NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-3UTRENST00000465486ENST00000372298NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000465486ENST00000372297NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000465486ENST00000372312NUP214chr9

134006223

+AIF1Lchr9

133986984

+
intron-5UTRENST00000465486ENST00000372301NUP214chr9

134006223

+AIF1Lchr9

133986984

+

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FusionProtFeatures for NUP214_AIF1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

AIF1L

Q9BQI0

May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}. Actin-binding protein that promotes actin bundling. Mayneither bind calcium nor depend on calcium for function.{ECO:0000269|PubMed:18699778}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536151_1932212091RepeatNote=Blade 3
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+53641_932212091RepeatNote=Blade 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+53694_1502212091RepeatNote=Blade 2
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536151_1932212081RepeatNote=Blade 3
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+53641_932212081RepeatNote=Blade 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+53694_1502212081RepeatNote=Blade 2
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536151_1932212092RepeatNote=Blade 3
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+53641_932212092RepeatNote=Blade 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+53694_1502212092RepeatNote=Blade 2
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000247291+1660_7131151Calcium binding1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372300+1660_7131103Calcium binding1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372302+1660_7131143Calcium binding1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372309+2760_7157177Calcium binding1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000247291+1647_8231151DomainEF-hand 1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000247291+1683_11731151DomainEF-hand 2%3B degenerate
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372300+1647_8231103DomainEF-hand 1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372300+1683_11731103DomainEF-hand 2%3B degenerate
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372302+1647_8231143DomainEF-hand 1
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372302+1683_11731143DomainEF-hand 2%3B degenerate
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372309+2783_11757177DomainEF-hand 2%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536680_12092212091Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536680_12092212081Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536680_12092212092Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+5361213_20902212091Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+5361213_20902212081Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+5361213_20902212092Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+5361409_20842212091RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+5361427_20852212091RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+53641_4042212091RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536481_20762212091RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536740_7682212091RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536861_8822212091RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+5361409_20842212081RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+5361427_20852212081RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+53641_4042212081RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536481_20762212081RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536740_7682212081RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536861_8822212081RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+5361409_20842212092RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+5361427_20852212092RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+53641_4042212092RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536481_20762212092RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536740_7682212092RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536861_8822212092RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536194_2392212091RepeatNote=Blade 4
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536240_3032212091RepeatNote=Blade 5
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536304_3592212091RepeatNote=Blade 6
HgeneNUP214chr9:134006223chr9:133986984ENST00000359428+536360_4042212091RepeatNote=Blade 7
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536194_2392212081RepeatNote=Blade 4
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536240_3032212081RepeatNote=Blade 5
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536304_3592212081RepeatNote=Blade 6
HgeneNUP214chr9:134006223chr9:133986984ENST00000411637+536360_4042212081RepeatNote=Blade 7
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536194_2392212092RepeatNote=Blade 4
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536240_3032212092RepeatNote=Blade 5
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536304_3592212092RepeatNote=Blade 6
HgeneNUP214chr9:134006223chr9:133986984ENST00000451030+536360_4042212092RepeatNote=Blade 7
TgeneAIF1Lchr9:134006223chr9:133986984ENST00000372309+2747_8257177DomainEF-hand 1


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FusionGeneSequence for NUP214_AIF1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP214_AIF1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, NUPL2, NUP214, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1AIF1LELAVL1, BAG3, LUZP4, ABCE1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP214_AIF1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP214_AIF1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource