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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25221

FusionGeneSummary for NUP214_AGGF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP214_AGGF1
Fusion gene ID: 25221
HgeneTgene
Gene symbol

NUP214

AGGF1

Gene ID

8021

55109

Gene namenucleoporin 214angiogenic factor with G-patch and FHA domains 1
SynonymsCAIN|CANGPATC7|GPATCH7|HSU84971|HUS84971|VG5Q
Cytomap

9q34.13

5q13.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDaangiogenic factor with G patch and FHA domains 1G patch domain-containing protein 7angiogenic factor VG5Qvasculogenesis gene on 5q protein
Modification date2018052320180523
UniProtAcc

P35658

Q8N302

Ensembl transtripts involved in fusion geneENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 
ENST00000503538, 
ENST00000312916, ENST00000506806, 
Fusion gene scores* DoF score11 X 11 X 4=4844 X 4 X 4=64
# samples 1114
** MAII scorelog2(11/484*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/64*10)=1.12928301694497
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP214 [Title/Abstract] AND AGGF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAGGF1

GO:0001938

positive regulation of endothelial cell proliferation

14961121

TgeneAGGF1

GO:0007155

cell adhesion

14961121

TgeneAGGF1

GO:0045766

positive regulation of angiogenesis

14961121


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF082622NUP214chr9

134103618

-AGGF1chr5

76359041

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359428ENST00000503538NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000359428ENST00000312916NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000359428ENST00000506806NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000411637ENST00000503538NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000411637ENST00000312916NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000411637ENST00000506806NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000451030ENST00000503538NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000451030ENST00000312916NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000451030ENST00000506806NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000483497ENST00000503538NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000483497ENST00000312916NUP214chr9

134103618

-AGGF1chr5

76359041

-
5CDS-intronENST00000483497ENST00000506806NUP214chr9

134103618

-AGGF1chr5

76359041

-
intron-intronENST00000465486ENST00000503538NUP214chr9

134103618

-AGGF1chr5

76359041

-
intron-intronENST00000465486ENST00000312916NUP214chr9

134103618

-AGGF1chr5

76359041

-
intron-intronENST00000465486ENST00000506806NUP214chr9

134103618

-AGGF1chr5

76359041

-

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FusionProtFeatures for NUP214_AGGF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

AGGF1

Q8N302

May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}. Promotes angiogenesis and the proliferation ofendothelial cells. Able to bind to endothelial cells and promotecell proliferation, suggesting that it may act in an autocrinefashion. {ECO:0000269|PubMed:14961121}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP214_AGGF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP214_AGGF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP214_AGGF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP214_AGGF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAGGF1C0022739Klippel-Trenaunay-Weber Syndrome1CTD_human;ORPHANET;UNIPROT