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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25199

FusionGeneSummary for NUP160_RPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP160_RPS6
Fusion gene ID: 25199
HgeneTgene
Gene symbol

NUP160

RPS6

Gene ID

23279

6194

Gene namenucleoporin 160ribosomal protein S6
Synonyms-S6
Cytomap

11p11.2

9p22.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup160160 kDa nucleoporinnucleoporin 160kDnucleoporin 160kDanucleoporin Nup16040S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
Modification date2018052320180522
UniProtAcc

Q12769

P62753

Ensembl transtripts involved in fusion geneENST00000378460, ENST00000530326, 
ENST00000528071, ENST00000528501, 
ENST00000531016, ENST00000532747, 
ENST00000526870, 
ENST00000380394, 
ENST00000498815, ENST00000380384, 
ENST00000315377, ENST00000380381, 
Fusion gene scores* DoF score5 X 3 X 4=603 X 4 X 1=12
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP160 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP160

GO:0006406

mRNA export from nucleus

11684705

TgeneRPS6

GO:0031929

TOR signaling

16428328

TgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG874971NUP160chr11

47800689

+RPS6chr9

19378842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378460ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000378460ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000378460ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000378460ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000378460ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000530326ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000530326ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000530326ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000530326ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000530326ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000528071ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528071ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528071ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528071ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000528071ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000528501ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528501ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528501ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000528501ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000528501ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000531016ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000531016ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000531016ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000531016ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000531016ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000532747ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000532747ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000532747ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000532747ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000532747ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3CDSENST00000526870ENST00000380394NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000526870ENST00000498815NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000526870ENST00000380384NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-intronENST00000526870ENST00000315377NUP160chr11

47800689

+RPS6chr9

19378842

-
intron-3UTRENST00000526870ENST00000380381NUP160chr11

47800689

+RPS6chr9

19378842

-

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FusionProtFeatures for NUP160_RPS6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP160

Q12769

RPS6

P62753

Involved in poly(A)+ RNA transport.{ECO:0000269|PubMed:11684705}. May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP160_RPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP160_RPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP160_RPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRPS6P62753DB11638Artenimol40S ribosomal protein S6small moleculeapproved|investigational

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RelatedDiseases for NUP160_RPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPS6C0038356Stomach Neoplasms1CTD_human
TgeneRPS6C1458155Mammary Neoplasms1CTD_human
TgeneRPS6C2239176Liver carcinoma1CTD_human