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Fusion gene ID: 25185 |
FusionGeneSummary for NUP153_MAK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP153_MAK | Fusion gene ID: 25185 | Hgene | Tgene | Gene symbol | NUP153 | MAK | Gene ID | 9972 | 4117 |
| Gene name | nucleoporin 153 | male germ cell associated kinase | |
| Synonyms | HNUP153|N153 | RP62 | |
| Cytomap | 6p22.3 | 6p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore complex protein Nup153153 kDa nucleoporinnuclear pore complex protein hnup153nucleoporin 153kDnucleoporin 153kDanucleoporin Nup153 | serine/threonine-protein kinase MAKmale germ cell-associated kinase retinal-enriched isoformserine/threonine protein kinase MAKtesticular secretory protein Li 28 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P49790 | P20794 | |
| Ensembl transtripts involved in fusion gene | ENST00000262077, ENST00000537253, | ENST00000354489, ENST00000313243, ENST00000474039, ENST00000538030, ENST00000536370, | |
| Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 3 X 3 X 3=27 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NUP153 [Title/Abstract] AND MAK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUP153 | GO:0046832 | negative regulation of RNA export from nucleus | 22253824 |
| Tgene | MAK | GO:0006468 | protein phosphorylation | 21986944 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DH-A66G-01A | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000262077 | ENST00000354489 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| Frame-shift | ENST00000262077 | ENST00000313243 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| Frame-shift | ENST00000262077 | ENST00000474039 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| In-frame | ENST00000262077 | ENST00000538030 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| In-frame | ENST00000262077 | ENST00000536370 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| Frame-shift | ENST00000537253 | ENST00000354489 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| Frame-shift | ENST00000537253 | ENST00000313243 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| Frame-shift | ENST00000537253 | ENST00000474039 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| In-frame | ENST00000537253 | ENST00000538030 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
| In-frame | ENST00000537253 | ENST00000536370 | NUP153 | chr6 | 17675136 | - | MAK | chr6 | 10819173 | - |
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FusionProtFeatures for NUP153_MAK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP153 | MAK |
| Component of the nuclear pore complex (NPC), a complexrequired for the trafficking across the nuclear envelope.Functions as a scaffolding element in the nuclear phase of the NPCessential for normal nucleocytoplasmic transport of proteins andmRNAs. Involved in the quality control and retention of unsplicedmRNAs in the nucleus; in association with TPR, regulates thenuclear export of unspliced mRNA species bearing constitutivetransport element (CTE) in a NXF1- and KHDRBS1-independent manner.Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components ofthe NPC to the pore membrane. Possible DNA-binding subunit of thenuclear pore complex (NPC). {ECO:0000269|PubMed:12802065,ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}. | Essential for the regulation of ciliary length andrequired for the long-term survival of photoreceptors (Bysimilarity). Phosphorylates FZR1 in a cell cycle-dependent manner.Plays a role in the transcriptional coactivation of AR. Could playan important function in spermatogenesis. May play a role inchromosomal stability in prostate cancer cells. {ECO:0000250,ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154,ECO:0000269|PubMed:21986944}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUP153_MAK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_284aa MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_284aa MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_284aa MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_284aa MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_852nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_852nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_852nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_852nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_2979nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA GCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGAAAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGA AGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAAGTTATCAGAGAAAATGACCATCTTTATTTTATATTTGA ATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTCCCTGAATCAGTCATCAGAAATATTATGTATCAAATATT GCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAACCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAA AATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACTGATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGT TTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGAAGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTT CCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGGACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCT GGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAAACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCT CATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAGGCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATT AGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGA GCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCC ACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCC AACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTT GGAGGACTATGATTTCGGAGCCTCCCATTCCAAGAAGCCAAGCATGGGTGTTTTTAAAGAAAAAAGGAAAAAAGATTCTCCATTTCGTCA ACAGGTGAAGATGGCTGTTATTTCCCTCTCAGCACACCAGTTTCCCACGTTATGAATCCAACTGCAGCCGTTGCAGGACAGATAGAAACA TGTTACACACAAGCTTCCAGAGCCAGTACCCTCAGGCTCCAACCACTCGACAGGGGAAAACAAGAGCTTACCTGCTGTTACTTCCCTAAA ATCTGATTCCGAATTGTCAACTGCTCCAACCTCTAAACAGTACTACTTGAAACAATCAAGATATCTTCCAGGTGTGAATCCCAAGAAGGT GTCCTTGATAGCCAGTGGAAAGGAAATAAACCCCCACACTTGGAGCAACCAGTTATTCCCCAAGTCACTGGGACCCGTTGGGGCAGAACT TGCTTTCAAAAGGAGCAATGCAGGAAATCTTGGAAGTTATGCTACTTACAATCAGTCAGGATATATTCCTTCCTTTCTCAAAAAAGAAGT GCAGTCAGCTGGCCAGAGGATCCACTTAGCACCTCTCAATGCAACGGCTTCAGAATATACCTGGAACACAAAAACTGGTCGGGGGCAGTT TTCAGGACGTACTTATAATCCTACAGCAAAAAACCTAAATATTGTGAACCGTGCACAGCCCATTCCCTCAGTGCATGGGAGGACAGACTG GGTGGCCAAGTATGGAGGCCACCGGTAGGAGTCTATGGTGTGAAACCCTACAGCATTGCTCCGTAGAGTACGTGCAAGTTCCTTGACCCT GGGAAATGTCTACAAATGTCTATTTCTACTGAGTTCTGGAAGAAATATGCAAAAGTGGGTACTTGGAAGGGCAAAAATCATCCCCTATTT TACTTATTTCCAAGAAATGCATTTTCTTAGCATCATTGCCCACAGTGTTGATATATGGGTAGGATGTTACAAAGTATTGAATAAACTATT >In-frame_NUP153_ENST00000262077_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_2293nt ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA GCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGAAAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGA AGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAAGTTATCAGAGAAAATGACCATCTTTATTTTATATTTGA ATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTCCCTGAATCAGTCATCAGAAATATTATGTATCAAATATT GCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAACCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAA AATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACTGATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGT TTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGAAGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTT CCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGGACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCT GGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAAACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCT CATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAGCCCTGCTTTTTAGTGGAAGTGGAAAGACCTAATTAGGG AGAGAGGTTGGTTAAGTTGTAGAATATGAAGACCATTTAAAGTACCAAGCTGCCTTCTGTTCCTCTAAAAACTGCCCTTACACATGGGAG GAGTTAACTGTTGGTCAGGGCTATGTTCCCACCTATGTGGGGACTGGCTAAAGGCAGGAGGTTCAGGGGAACAGAGCTTGACCATCTTAA GGAACCCATCCCCCCAAAAATGACCAGCTACTTTGCCCAGGCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTC AAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCT GCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAG CGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAA TGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTTGGAGGACTATGA >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000538030_chr6_10819173_-_3017nt TTACCCGCCCCGGAGCGGGAAGCGGCGGAGGCTCCGCCATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGA CGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAGCAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTA AGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAACAAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCT GGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGATGAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCA GTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCAAATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATT TTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCATCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGG AAATTAAAGATTCTACCTCTCAGCATGATGATGATAACATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTG TTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCAGAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAA AACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCCCCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTC CTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCAGCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGA AAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGAAGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAA GTTATCAGAGAAAATGACCATCTTTATTTTATATTTGAATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTC CCTGAATCAGTCATCAGAAATATTATGTATCAAATATTGCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAA CCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAAAATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACT GATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGTTTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGA AGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTTCCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGG ACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCTGGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAA ACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCTCATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAG GCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTG CAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCA AAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCG CCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGT CAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTTGGAGGACTATGATTTCGGAGCCTCCCATTCCAAGAAGCCAAGCATGGGTGTT TTTAAAGAAAAAAGGAAAAAAGATTCTCCATTTCGTCAACAGGTGAAGATGGCTGTTATTTCCCTCTCAGCACACCAGTTTCCCACGTTA TGAATCCAACTGCAGCCGTTGCAGGACAGATAGAAACATGTTACACACAAGCTTCCAGAGCCAGTACCCTCAGGCTCCAACCACTCGACA GGGGAAAACAAGAGCTTACCTGCTGTTACTTCCCTAAAATCTGATTCCGAATTGTCAACTGCTCCAACCTCTAAACAGTACTACTTGAAA CAATCAAGATATCTTCCAGGTGTGAATCCCAAGAAGGTGTCCTTGATAGCCAGTGGAAAGGAAATAAACCCCCACACTTGGAGCAACCAG TTATTCCCCAAGTCACTGGGACCCGTTGGGGCAGAACTTGCTTTCAAAAGGAGCAATGCAGGAAATCTTGGAAGTTATGCTACTTACAAT CAGTCAGGATATATTCCTTCCTTTCTCAAAAAAGAAGTGCAGTCAGCTGGCCAGAGGATCCACTTAGCACCTCTCAATGCAACGGCTTCA GAATATACCTGGAACACAAAAACTGGTCGGGGGCAGTTTTCAGGACGTACTTATAATCCTACAGCAAAAAACCTAAATATTGTGAACCGT GCACAGCCCATTCCCTCAGTGCATGGGAGGACAGACTGGGTGGCCAAGTATGGAGGCCACCGGTAGGAGTCTATGGTGTGAAACCCTACA GCATTGCTCCGTAGAGTACGTGCAAGTTCCTTGACCCTGGGAAATGTCTACAAATGTCTATTTCTACTGAGTTCTGGAAGAAATATGCAA AAGTGGGTACTTGGAAGGGCAAAAATCATCCCCTATTTTACTTATTTCCAAGAAATGCATTTTCTTAGCATCATTGCCCACAGTGTTGAT >In-frame_NUP153_ENST00000537253_chr6_17675136_-_MAK_ENST00000536370_chr6_10819173_-_2331nt TTACCCGCCCCGGAGCGGGAAGCGGCGGAGGCTCCGCCATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGA CGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAGCAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTA AGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAACAAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCT GGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGATGAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCA GTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCAAATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATT TTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCATCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGG AAATTAAAGATTCTACCTCTCAGCATGATGATGATAACATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTG TTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCAGAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAA AACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCCCCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTC CTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCAGCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGA AAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGAAGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAA GTTATCAGAGAAAATGACCATCTTTATTTTATATTTGAATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTC CCTGAATCAGTCATCAGAAATATTATGTATCAAATATTGCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAA CCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAAAATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACT GATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGTTTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGA AGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTTCCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGG ACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCTGGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAA ACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCTCATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAG CCCTGCTTTTTAGTGGAAGTGGAAAGACCTAATTAGGGAGAGAGGTTGGTTAAGTTGTAGAATATGAAGACCATTTAAAGTACCAAGCTG CCTTCTGTTCCTCTAAAAACTGCCCTTACACATGGGAGGAGTTAACTGTTGGTCAGGGCTATGTTCCCACCTATGTGGGGACTGGCTAAA GGCAGGAGGTTCAGGGGAACAGAGCTTGACCATCTTAAGGAACCCATCCCCCCAAAAATGACCAGCTACTTTGCCCAGGCATTGAAACAC CCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAA TCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAG CAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTA TTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTC |
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FusionGenePPI for NUP153_MAK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP153 | NUTF2, BRCA1, TPR, TRN-GTT2-1, KPNB1, RAN, XPO1, NXF2, NUP50, XPO5, SENP2, IPO5, USP11, USP20, APC, MYC, MAPK1, MAPK3, SMAD3, XPO7, SIRT7, CTNNB1, RANBP2, CUL3, NUP107, NUP54, PNPT1, DPY30, EEF1B2, MEA1, CSTF2, FIP1L1, PRKCSH, EIF4B, NCAPD2, C1QBP, ESR1, LMNA, HDAC11, OBSL1, NUP153, EGFR, NUP62, NUSAP1, TDP1, PPP1CC, PPP1CA, G3BP2, IER2, FBXW11, IFI16, NXF1, NUP43, NUP85, NUP133, NUP160, NUP35, HERC2, CLK1, B9D2, CENPC, RCC1, GLE1, KIFC1, KPNA1, KPNA2, KPNA3, KPNA4, TNPO1, MCM4, NUP88, NUP98, RANGAP1, SMARCC2, SMARCD2, SMARCE1, SUMO2, UBE2I, SUMO1, NUP214, AAAS, RAE1, NUP155, NUP93, POM121, SEH1L, IPO7, NUPL2, NUP205, NUP210, NUP188, KPNA6, CNOT10, SENP1, TMEM214, SMPD4, NDC1, KLHL7, NUP37, PPP1R3B, TMEM209, CDCA2, RGPD8, POM121C, SNW1, CTDSPL2, PPM1D, SREK1IP1, TSR1, FOXA1 | MAK | MAK, CDK20, FZR1, APP, SLAMF7, SERINC1, ANAPC11, NDUFB7, PPP2CB, SND1, PVRL3, FLG, ICK, KIAA0556, PRDX2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP153_MAK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP153_MAK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MAK | C3280042 | RETINITIS PIGMENTOSA 62 | 1 | UNIPROT |
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