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Fusion gene ID: 25181 |
FusionGeneSummary for NUP133_PARPBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP133_PARPBP | Fusion gene ID: 25181 | Hgene | Tgene | Gene symbol | NUP133 | PARPBP | Gene ID | 55746 | 55010 |
| Gene name | nucleoporin 133 | PARP1 binding protein | |
| Synonyms | hNUP133 | AROM|C12orf48|PARI | |
| Cytomap | 1q42.13 | 12q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore complex protein Nup133133 kDa nucleoporinnucleoporin 133kDnucleoporin 133kDanucleoporin Nup133 | PCNA-interacting partner | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8WUM0 | Q9NWS1 | |
| Ensembl transtripts involved in fusion gene | ENST00000261396, ENST00000537506, ENST00000366678, ENST00000485119, | ENST00000327680, ENST00000378128, ENST00000541394, ENST00000543784, ENST00000537257, ENST00000358383, ENST00000392911, ENST00000535811, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 1 X 2=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NUP133 [Title/Abstract] AND PARPBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUP133 | GO:0006406 | mRNA export from nucleus | 11684705 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-29-1691-01A | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261396 | ENST00000327680 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| In-frame | ENST00000261396 | ENST00000378128 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| Frame-shift | ENST00000261396 | ENST00000541394 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| In-frame | ENST00000261396 | ENST00000543784 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000261396 | ENST00000537257 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000261396 | ENST00000358383 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000261396 | ENST00000392911 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-3UTR | ENST00000261396 | ENST00000535811 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| Frame-shift | ENST00000537506 | ENST00000327680 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| In-frame | ENST00000537506 | ENST00000378128 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| Frame-shift | ENST00000537506 | ENST00000541394 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| In-frame | ENST00000537506 | ENST00000543784 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000537506 | ENST00000537257 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000537506 | ENST00000358383 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-intron | ENST00000537506 | ENST00000392911 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| 5CDS-3UTR | ENST00000537506 | ENST00000535811 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000366678 | ENST00000327680 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000366678 | ENST00000378128 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000366678 | ENST00000541394 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000366678 | ENST00000543784 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000366678 | ENST00000537257 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000366678 | ENST00000358383 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000366678 | ENST00000392911 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3UTR | ENST00000366678 | ENST00000535811 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000485119 | ENST00000327680 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000485119 | ENST00000378128 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000485119 | ENST00000541394 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3CDS | ENST00000485119 | ENST00000543784 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000485119 | ENST00000537257 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000485119 | ENST00000358383 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-intron | ENST00000485119 | ENST00000392911 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
| intron-3UTR | ENST00000485119 | ENST00000535811 | NUP133 | chr1 | 229633883 | - | PARPBP | chr12 | 102589729 | + |
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FusionProtFeatures for NUP133_PARPBP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP133 | PARPBP |
| Involved in poly(A)+ RNA transport.{ECO:0000269|PubMed:11684705}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUP133_PARPBP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_297aa MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPV KVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATR EGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSS >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_297aa MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPV KVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATR EGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSS >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_281aa MGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVDDQLT INIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLAGEDTY TEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTRVXIHLLEDQQLE >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_281aa MGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVDDQLT INIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLAGEDTY TEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTRVXIHLLEDQQLE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_892nt ATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGG ACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCG CGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTT AAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAA GAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCAC TGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGA GAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGT TTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATT CATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGT >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_892nt ATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGG ACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCG CGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTT AAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAA GAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCAC TGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGA GAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGT TTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATT CATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGT >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_844nt ATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCA GTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCT GTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACC ATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTA TCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAA GCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTAC ACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGA AGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGT CGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAA >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_844nt ATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCA GTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCT GTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACC ATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTA TCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAA GCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTAC ACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGA AGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGT CGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_2481nt CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT CTTATATGCTTTAGGTTTATGTATCTATAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTA TTATTTTGGTCTACAGTGTATGTAAGGTTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAG TTTAATGCACAGAGAAAGCATATCATTTCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTA TAGTAGCAGTATGGGCTTCTCCTCCCATTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTT GCCAACAAGGTCGGTAGACTCTTCCCAGCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCAC ACAAAATTTATTAAGAAAAAAAGAATGGATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCC CACATTTTTGGCAGGTGTAATTGAGCCATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAA TGGTGGTAGGATGTAAGAATTGAATTTTGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCA TCCCCAATTTCTCTCTTTTCTTGTGTTGATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAA GGTTTTATAGCCAGATTCAGTGGCAGACCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTT AGCTATCGTATTCGGAGTGGAACTATAATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTT AAAAATACCTTAGATGCAAATTTATAGGAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGA AATATCGTCAGTCGTCCTAATGCATATTGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTA >In-frame_NUP133_ENST00000261396_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_1329nt CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000378128_chr12_102589729_+_2448nt ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC ATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTATGTAAGGTTAGTA TGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCATATCATTTCAGTT ACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCTCCTCCCATTGGCA ATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACTCTTCCCAGCATAC ATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAAAAGAATGGATCTA GTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAATTGAGCCATGGTC TTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAATTGAATTTTGAAAA GACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTCTTGTGTTGATTCA GTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAGTGGCAGACCATGA TTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGGAACTATAATACAA TTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAATTTATAGGAGAAA AAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAATGCATATTGTGAC TGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCATTGAAATAAACGAC >In-frame_NUP133_ENST00000537506_chr1_229633883_-_PARPBP_ENST00000543784_chr12_102589729_+_1296nt ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC |
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FusionGenePPI for NUP133_PARPBP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP133 | SEH1L, NUP107, NUP43, NUP37, SEC13, NUP98, UBC, MYC, SIRT7, CENPF, PSAP, FLNC, DDX3X, DDB1, NONO, DYNC1H1, DBN1, POLE4, CPSF7, DDX1, LMNA, HDAC11, FBXO6, ACTR1A, OBSL1, EED, RNF2, AHCTF1, C19orf53, NUP160, ZMYM2, NTRK1, IFI16, WWOX, POM121, NUP50, RANBP2, SENP2, RPL26L1, NUP153, TMPO, B9D2, CDK4, KPNB1, VIM, FOXI2, FOXL1, FOXP3, FOXQ1, PTPMT1, SPAST, TPTE2, RAF1, RPGRIP1L, UBE2A, BRCA1 | PARPBP | PCNA, RAD51, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP133_PARPBP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP133_PARPBP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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