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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25169

FusionGeneSummary for NUMB_SLC39A9

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMB_SLC39A9
Fusion gene ID: 25169
HgeneTgene
Gene symbol

NUMB

SLC39A9

Gene ID

8650

55334

Gene nameNUMB, endocytic adaptor proteinsolute carrier family 39 member 9
SynonymsC14orf41|S171|c14_5527ZIP-9|ZIP9
Cytomap

14q24.2-q24.3

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionprotein numb homologh-Numbnumb homologzinc transporter ZIP9solute carrier family 39 (zinc transporter), member 9zinc transporter SLC39A9zrt- and Irt-like protein 9
Modification date2018052220180519
UniProtAcc

P49757

Q9NUM3

Ensembl transtripts involved in fusion geneENST00000554546, ENST00000356296, 
ENST00000557597, ENST00000555238, 
ENST00000355058, ENST00000359560, 
ENST00000555394, ENST00000454166, 
ENST00000544991, ENST00000560335, 
ENST00000555738, ENST00000559312, 
ENST00000554521, ENST00000535282, 
ENST00000556600, ENST00000556772, 
ENST00000555245, ENST00000556605, 
ENST00000336643, ENST00000031146, 
ENST00000557046, 
Fusion gene scores* DoF score10 X 7 X 7=4904 X 5 X 4=80
# samples 116
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUMB [Title/Abstract] AND SLC39A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-ER-A196-01ANUMBchr14

73876645

-SLC39A9chr14

69890811

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000554546ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000554546ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000554546ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000554546ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000554546ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000356296ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000356296ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000356296ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000356296ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000356296ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000557597ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000557597ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000557597ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000557597ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000557597ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555238ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555238ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555238ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555238ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555238ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000355058ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000355058ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000355058ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000355058ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000355058ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000359560ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000359560ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000359560ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000359560ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000359560ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555394ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555394ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555394ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555394ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000555394ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000454166ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000454166ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000454166ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000454166ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000454166ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000544991ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000544991ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000544991ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000544991ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000544991ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000560335ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000560335ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000560335ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000560335ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000560335ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000555738ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000555738ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000555738ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000555738ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000555738ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000559312ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000559312ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000559312ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000559312ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000559312ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000554521ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000554521ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000554521ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000554521ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000554521ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000535282ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000535282ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000535282ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000535282ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000535282ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000556600ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000556600ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000556600ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000556600ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
5UTR-3UTRENST00000556600ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000556772ENST00000555245NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000556772ENST00000556605NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000556772ENST00000336643NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000556772ENST00000031146NUMBchr14

73876645

-SLC39A9chr14

69890811

+
intron-3UTRENST00000556772ENST00000557046NUMBchr14

73876645

-SLC39A9chr14

69890811

+

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FusionProtFeatures for NUMB_SLC39A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUMB

P49757

SLC39A9

Q9NUM3

May act as a zinc-influx transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUMB_SLC39A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUMB_SLC39A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUMBAP2A1, DPYSL2, L1CAM, RALBP1, ITCH, MDM2, NOTCH1, LNX1, SIAH1, TP53, GLI1, EPS15, APP, EGFR, PRKCA, PRKCZ, PRKCE, PRKCB, RPL3, AP2M1, IRS1, OLIG1, FRS3, LNX2, MAPK8IP2, TERF2, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, GAK, IGBP1, ATP6AP2, KIAA1107, GTSE1, ANLN, CDH1, CTDSPL, KBTBD7, UNC5CL, TULP3, STAMBPL1, COL10A1, DCAF7SLC39A9MOV10, NXF1, CD44, TTI2, FKRP, HIP1R, DNAJC13, TPST2, SLC25A24, OSTC, HPCAL1, CANT1, SYNGR3, METTL16, KIAA0368, SFXN5, MTX3, TTK, RMND1, GOLM1, SRPR, B4GALT5, STIM1, NR2F2, MTFP1, CDC23, IDH2, SLC25A17, HELLS, DNM1, ABCB8, MSH3, PXMP2, NEK7, PDXDC1, MPC2, BDH1, XPO7, RIF1, CCDC132, VAPB, MTX1, TBRG4, APOOL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUMB_SLC39A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUMB_SLC39A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource