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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25166

FusionGeneSummary for NUMB_HEATR4

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMB_HEATR4
Fusion gene ID: 25166
HgeneTgene
Gene symbol

NUMB

HEATR4

Gene ID

8650

399671

Gene nameNUMB, endocytic adaptor proteinHEAT repeat containing 4
SynonymsC14orf41|S171|c14_5527-
Cytomap

14q24.2-q24.3

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein numb homologh-Numbnumb homologHEAT repeat-containing protein 4
Modification date2018052220180519
UniProtAcc

P49757

Q86WZ0

Ensembl transtripts involved in fusion geneENST00000554546, ENST00000356296, 
ENST00000557597, ENST00000555238, 
ENST00000355058, ENST00000359560, 
ENST00000555394, ENST00000454166, 
ENST00000544991, ENST00000560335, 
ENST00000555738, ENST00000559312, 
ENST00000554521, ENST00000535282, 
ENST00000556600, ENST00000556772, 
ENST00000553558, ENST00000334988, 
ENST00000566478, ENST00000560393, 
Fusion gene scores* DoF score10 X 7 X 7=4902 X 3 X 3=18
# samples 113
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUMB [Title/Abstract] AND HEATR4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8485-01ANUMBchr14

73876645

-HEATR4chr14

73996948

-
TCGARVUCECTCGA-AX-A2H4-01ANUMBchr14

73876645

-HEATR4chr14

73945547

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000554546ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000554546ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000554546ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000554546ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000356296ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000356296ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000356296ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000356296ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000557597ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000557597ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000557597ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000557597ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000555238ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555238ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555238ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555238ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000355058ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000355058ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000355058ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000355058ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000359560ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000359560ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000359560ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000359560ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000555394ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555394ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555394ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000555394ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000454166ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000454166ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000454166ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000454166ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000544991ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000544991ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000544991ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000544991ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000560335ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000560335ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000560335ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000560335ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000555738ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000555738ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000555738ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000555738ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000559312ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000559312ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000559312ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000559312ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000554521ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000554521ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000554521ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000554521ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000535282ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000535282ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000535282ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000535282ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-5UTRENST00000556600ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000556600ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000556600ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-intronENST00000556600ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-5UTRENST00000556772ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000556772ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000556772ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73996948

-
intron-intronENST00000556772ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73996948

-
5UTR-3CDSENST00000554546ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000554546ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000554546ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000554546ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000356296ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000356296ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000356296ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000356296ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000557597ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000557597ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000557597ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000557597ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000555238ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000555238ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000555238ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000555238ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000355058ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000355058ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000355058ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000355058ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000359560ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000359560ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000359560ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000359560ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000555394ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000555394ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000555394ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000555394ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000454166ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000454166ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000454166ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000454166ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000544991ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000544991ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000544991ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000544991ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000560335ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000560335ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000560335ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000560335ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000555738ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000555738ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000555738ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000555738ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000559312ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000559312ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000559312ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000559312ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000554521ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000554521ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000554521ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000554521ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000535282ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000535282ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000535282ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000535282ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000556600ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-3CDSENST00000556600ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000556600ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
5UTR-5UTRENST00000556600ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000556772ENST00000553558NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-3CDSENST00000556772ENST00000334988NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000556772ENST00000566478NUMBchr14

73876645

-HEATR4chr14

73945547

-
intron-5UTRENST00000556772ENST00000560393NUMBchr14

73876645

-HEATR4chr14

73945547

-

Top

FusionProtFeatures for NUMB_HEATR4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUMB

P49757

HEATR4

Q86WZ0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NUMB_HEATR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NUMB_HEATR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUMBAP2A1, DPYSL2, L1CAM, RALBP1, ITCH, MDM2, NOTCH1, LNX1, SIAH1, TP53, GLI1, EPS15, APP, EGFR, PRKCA, PRKCZ, PRKCE, PRKCB, RPL3, AP2M1, IRS1, OLIG1, FRS3, LNX2, MAPK8IP2, TERF2, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, GAK, IGBP1, ATP6AP2, KIAA1107, GTSE1, ANLN, CDH1, CTDSPL, KBTBD7, UNC5CL, TULP3, STAMBPL1, COL10A1, DCAF7HEATR4EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NUMB_HEATR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUMB_HEATR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource