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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25123

FusionGeneSummary for NUDT7_SAFB

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT7_SAFB
Fusion gene ID: 25123
HgeneTgene
Gene symbol

NUDT7

SAFB

Gene ID

283927

6294

Gene namenudix hydrolase 7scaffold attachment factor B
Synonyms-HAP|HET|SAB-B1|SAF-B|SAF-B1|SAFB1
Cytomap

16q23.1

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal coenzyme A diphosphatase NUDT7nudix (nucleoside diphosphate linked moiety X)-type motif 7scaffold attachment factor B1HSP27 ERE-TATA-binding proteinHSP27 estrogen response element-TATA box-binding proteinHsp27 ERE-TATA binding proteinglutathione S-transferase fusion proteinheat-shock protein (HSP27) estrogen response element and TATA box
Modification date2018052220180523
UniProtAcc

P0C024

Q15424

Ensembl transtripts involved in fusion geneENST00000564085, ENST00000268533, 
ENST00000568787, ENST00000437314, 
ENST00000563839, ENST00000564031, 
ENST00000292123, ENST00000592224, 
ENST00000586934, ENST00000454510, 
ENST00000433404, ENST00000588852, 
ENST00000538656, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 5=245
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT7 [Title/Abstract] AND SAFB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DY655726NUDT7chr16

77756393

-SAFBchr19

5666924

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000564085ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564085ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000268533ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000568787ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000437314ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000563839ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000292123NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000592224NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000586934NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000454510NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000433404NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000588852NUDT7chr16

77756393

-SAFBchr19

5666924

+
intron-intronENST00000564031ENST00000538656NUDT7chr16

77756393

-SAFBchr19

5666924

+

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FusionProtFeatures for NUDT7_SAFB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT7

P0C024

SAFB

Q15424

Coenzyme A diphosphatase which mediates the cleavage ofCoA, CoA esters and oxidized CoA with similar efficiencies,yielding 3',5'-ADP and the corresponding 4'-phosphopantetheinederivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di ormonophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPHor thymidine-5'-monophospho-p-nitrophenyl ester. May be requiredto eliminate oxidized CoA from peroxisomes, or regulate CoA andacyl-CoA levels in this organelle in response to metabolic demand.Does not play a role in U8 snoRNA decapping activity. Binds U8snoRNA (By similarity). {ECO:0000250}. Binds to scaffold/matrix attachment region (S/MAR) DNAand forms a molecular assembly point to allow the formation of a'transcriptosomal' complex (consisting of SR proteins and RNApolymerase II) coupling transcription and RNA processing (Bysimilarity). Can function as an estrogen receptor corepressor andcan also bind to the HSP27 promoter and decrease itstranscription. When associated with RBMX, binds to and stimulatestranscription from the SREBF1 promoter (By similarity). Caninhibit cell proliferation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDT7_SAFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT7_SAFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDT7_SAFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDT7_SAFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUDT7C0023903Liver neoplasms1CTD_human