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Fusion gene ID: 2512 |
FusionGeneSummary for ARHGEF11_SHC1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGEF11_SHC1 | Fusion gene ID: 2512 | Hgene | Tgene | Gene symbol | ARHGEF11 | SHC1 | Gene ID | 9826 | 6464 |
Gene name | Rho guanine nucleotide exchange factor 11 | SHC adaptor protein 1 | |
Synonyms | GTRAP48|PDZ-RHOGEF | SHC|SHCA | |
Cytomap | 1q23.1 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro | SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | O15085 | P29353 | |
Ensembl transtripts involved in fusion gene | ENST00000368194, ENST00000487682, ENST00000361409, ENST00000315174, | ENST00000368445, ENST00000368449, ENST00000448116, ENST00000368450, ENST00000368453, ENST00000606391, ENST00000490667, | |
Fusion gene scores | * DoF score | 10 X 4 X 6=240 | 8 X 4 X 5=160 |
# samples | 11 | 7 | |
** MAII score | log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/160*10)=-1.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARHGEF11 [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARHGEF11 | GO:0007186 | G-protein coupled receptor signaling pathway | 15755723 |
Hgene | ARHGEF11 | GO:0007266 | Rho protein signal transduction | 10026210 |
Hgene | ARHGEF11 | GO:0045893 | positive regulation of transcription, DNA-templated | 10026210 |
Tgene | SHC1 | GO:0000165 | MAPK cascade | 14676841 |
Tgene | SHC1 | GO:0000187 | activation of MAPK activity | 14676841 |
Tgene | SHC1 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-AB2V-01A | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000368194 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000368194 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000368194 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-3CDS | ENST00000487682 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000487682 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000487682 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
In-frame | ENST00000361409 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000361409 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000361409 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-3CDS | ENST00000315174 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000315174 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000315174 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
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FusionProtFeatures for ARHGEF11_SHC1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARHGEF11 | SHC1 |
May play a role in the regulation of RhoA GTPase byguanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13).Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPaseand may act as GTPase-activating protein (GAP) for GNA12 andGNA13. Involved in neurotrophin-induced neurite outgrowth.{ECO:0000269|PubMed:21670212}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | - | 0 | 12 | 411_474 | -72 | 584 | Compositional bias | Note=Pro-rich |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | - | 0 | 13 | 411_474 | -1 | 474 | Compositional bias | Note=Pro-rich |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | - | 0 | 13 | 411_474 | -1 | 475 | Compositional bias | Note=Pro-rich |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | - | 0 | 12 | 411_474 | -74 | 585 | Compositional bias | Note=Pro-rich |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | - | 0 | 12 | 156_339 | -72 | 584 | Domain | PID |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | - | 0 | 12 | 488_579 | -72 | 584 | Domain | SH2 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | - | 0 | 13 | 156_339 | -1 | 474 | Domain | PID |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | - | 0 | 13 | 488_579 | -1 | 474 | Domain | SH2 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | - | 0 | 13 | 156_339 | -1 | 475 | Domain | PID |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | - | 0 | 13 | 488_579 | -1 | 475 | Domain | SH2 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | - | 0 | 12 | 156_339 | -74 | 585 | Domain | PID |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | - | 0 | 12 | 488_579 | -74 | 585 | Domain | SH2 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | - | 0 | 12 | 340_487 | -72 | 584 | Region | Note=CH1 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | - | 0 | 13 | 340_487 | -1 | 474 | Region | Note=CH1 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | - | 0 | 13 | 340_487 | -1 | 475 | Region | Note=CH1 |
Tgene | >SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | - | 0 | 12 | 340_487 | -74 | 585 | Region | Note=CH1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 444_470 | 10 | 1523 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 444_470 | 10 | 1563 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 1094_1099 | 10 | 1523 | Compositional bias | Note=Poly-Pro |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 1094_1099 | 10 | 1563 | Compositional bias | Note=Poly-Pro |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 306_486 | 10 | 1523 | Domain | RGSL |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 47_126 | 10 | 1523 | Domain | PDZ |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 734_923 | 10 | 1523 | Domain | DH |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 965_1079 | 10 | 1523 | Domain | PH |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 306_486 | 10 | 1563 | Domain | RGSL |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 47_126 | 10 | 1563 | Domain | PDZ |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 734_923 | 10 | 1563 | Domain | DH |
Hgene | >ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 965_1079 | 10 | 1563 | Domain | PH |
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FusionGeneSequence for ARHGEF11_SHC1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ARHGEF11_ENST00000368194_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_10aa >In-frame_ARHGEF11_ENST00000361409_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_10aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ARHGEF11_ENST00000368194_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_32nt >In-frame_ARHGEF11_ENST00000361409_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_32nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ARHGEF11_ENST00000368194_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_8299nt AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAA TTGTCTTTCAGAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAA AGGAGAGAATATTTTCAGAGATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGA TTTTTATTTTATTTTTTTTTTTGGTGCAATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTC CATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGT ACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCA TATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTA AAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAA CCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTC TTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGAT CAAGACACCAAAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGAGGCTCC ACGTTGGGCGGGGATGGGGCCTGAAACTGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCCCAGGACTTCTGTGA CTCCTGGGCCACAGAGGTCCAACCAGGCTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCAGGGGGGCCAGGCTG GGCAGCAGCCCCTCTTTCACCTCAACTATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGTCTCTGTCATCGCTG GAGGAAGGGGCTTCTGGGTCCACCCCCCCGGAGGAGCTGCCTTCCCCATCAGCTTCATCCCTGGGGCCCATCCTGCCTCCTCTGCCTGGG GACGATAGTCCCACTACCCTGTGCTCCTTCTTCCCCCGGATGAGCAACCTGAGGCTGGCCAACCCGGCTGGGGGGCGCCCAGGGTCTAAG GGGGAGCCAGGAAGGGCAGCTGATGATGGGGAGGGGATCGTAGGGGCAGCCATGCCAGACTCAGGCCCCCTACCCCTCCTCCAGGACATG AACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTC AATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGGTTCGGTACATGGGTTGTGTGGAG GTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGT GCTAAGGGGGCGACAAGGAGGAGAAAGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCA ATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACATGCAATCTATCTCA TTTGCATCCGGCGGGGATCCGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGCCTGCCACATTCTGGAG TGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCACCCAAA CTGGTCACCCCTCATGACAGGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAAT GACTTCCCGGGGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCA CCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCA CCTCCACCACCCTGTCCAGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGT GGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCT CCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTG CTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAG CATTTGCTACTGGTGGACCCTGAGGGTGTGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGTCAGCCGG GAACTGCAAGGCGAGGTGTACAGATTATTGATGATGAACCTCAAGCCCAGACCAGTGGTGGAGGGTGCTGTTCTTCTGGATAACTGTTCA CGCCTAAGAAATTAAAAGACAGAACAAAACTGTGGATCATTGCCCTCAACATGAAGACTGCCATATTCCAAGTCACATTATTTTACCAAT GGAATTATAGAATTAACAGTATTTTAAATTACGTTTATAACACTGCAGAGACCTTAAGTGCTAAACTTAGTGGAGTTTGTGACCAGAGAA TTGGCATTTTCTACAAATGTTTTTTTTTGTTTTTTTTTTGTTTTTTTTTGTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTG GAGTGCACTGGCTTGATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACT ATAGGCGCCCACCACGACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAGGTTAGCCAGGATGGTCTCGATCTCCT GACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTACAAATGTTAACAAAGCAA TTACCAATGGCCTTTTTACATATTTTTTCTTTAATGAGGAATAATATGCATGTAGAAAAGACCTACTTAAAGTCTTCATTTATATTCTTT CAAATCAAATCTTTATTTAATAACTTATATATGTTGTTGGAATGGTTACATTTTTGCAGCCCTTTGTATTTTGTGGTAGTTGAAATTGTA TCACTTCTAAACAGCAAACTGTTTTTGTTTTTAATTAGCAGATATCTGAAGTACTATTTTTGCAGGGTTTGCACAGGCCCGTAACTGTCT ACTACTTTGATATAATCTGTATACATCCTGTATGCTGAGCTGGTAAAATACATTGTAAATTACATATTAAATATTTTATCTGCTTTTACA AGCGCAAGGTGCAAAAATATATACAATAGTCTCATTGATGACTGTAAAGTGAATTAACATTTGGTGATTATGCCTAGCTTTTTTGACTAA TATAAAGATCATAGCTCCCCTTCACTTCTGTCTTAACTTGAACATGGCGTGTTTAAATTTTCATACATACTTTACTTGAATTATTGCTGT TGTCACATATTTTTGCCTCTGTGAGTTCATCTGATGATTGAGCAGTAGCATTTGCCTTTTGGGTTTTTTGTTTGTTATTATAGAAGAGAT GACTTCTGCTGATTTTGCTTTAGAATGGTTACCTTAGAAGAATTTGGGTGGCTCATGTTGAATTTCACTTCTGCAATAGCTTTCATTTTC TCATAGGCTTTATAAGAGATGGGTTCAGTGGTATGAGCAGAGGAAGAGATCCCAGATAGTAGCCAGTTAACCAAGACTCATTCATATAGC ACGTAGTTTATGTTCCTGAGGCAGCACTTTTAGATCCTTTGTGAGCAAGTTCTATTTGTTCATTGCTTGCCAGAGATGAACACAGAATGT TCTGTTTCATTTTACAAGAACTATCCTGAGTTTCTGTGGATGGAAACATTACATGTAATGCAGATATAGTGAACACTGGAAAGATTTATT AAAGAATTATATTTGTGTATACTTTATAAATTAGTCCCTCATTAGATTTTTTTTTCTTAAGCATAAGACTGAACTTAAATGTGTTAATTT TAGTAGAATCAGGCACTGCTCGCAGAAGGAACACAGATTGTAGAGATTAACATAAATTGTTCTTGTTCTAATATATATATTTTTTCATTT CTGTCGTGCTTGGAAAACTAGTAAATATTATGTCTAAGATAAAATGGAATGGCCCCTGGATTTACTTCTTATAAGAAGCAGTAGTATGTA ATAAAGCTATTAGCATGAGCAATTAAGAGGCTATAAAGAGATTATAGTTACAAAAGAAATACTGCCATATTTTTAAGTTAATAACTTAAA CCTTCTCAAATGGGTTAAAAGTTGAATGAATTGACACCCTGATGTTATGATGTTGGAATTTTAACTTAAACTGGGAGGCATTCTGTGAGC CTTCACTTTACCTTCTTTAATTATTGTCCTTGCTAAACTCAACACAGACTTTTCTGTTATGTGTTTTTGAGGAAGTTGGGGTGGGAAGAG TCAGGGAGATAAGCTAAAATTGTCTTCTTTTATGGGGTAATTGTACTCTGTAGTCTCTTGGTTTCCTGTGAAGTTAGTATTTATGTGGGG GTGGGGGAAGGTAGCAAGAATCATGGGTATCACGGTACTTTGTTTTTGACCTCCTGGCTCTTTCAGACAGAGTGAAGAAAGCTTTTCCAT TCTTACTGTTGTAGAAGTAGATAGGAAATAAGCTTTTCTCATTACAGTGAAATATGTTTTAAAAACTAGAGTAGCTGGGCACAGAGGCAT GCATTTGTAGGGCCAGCTACTTGGGAGAGTGAGGCAGGAGGATCACTTGAGGCCAGGATTTCAAATCCAGCCTAGGTAACACTGAGACCT CCATCTCGTAAAAGGCACAAAAACTAGTTAGAGATGAAATTGAGCTTTATTTTAAAAAAACGTTCTAAAGCCTGATAATTGGAGAGCTAT ACTTCAGCTTTTCATCCTACTTTAATGAAACAGCTAGATAGGAACCTCTGCTCCAGAATTGCCAGATAATTATTGGTGGGTCATAACTAT TCTTCATATTTTTTTTTTCTTTTTTCTCCTTTGGTTTCTGTGTTATCTTTCTTAACCTCACGTATTTCTTTATCCTTTTTAGTGGGGGCC TGTAATTGAGGCTAATTCAATAGCAACAATAGACAACATGATATGGCTGCTGTCACTTTGAAACCCAAAAGGTCTTTGGGTAGGAATAGA GTAATGAAAGAGGACCAGTCAACTTCAGTATATATACAAAGGAAAGACAAAGAGATGATAAACCAAGGCTGAGGAAATTTTTCTGATGCT TTCTTCATTTCTCTAATATACCTTTTGCATTCTTTTTCTGATAATTGTGCTATTAGGCAGAAGACACAAGTTACCACGTTGTGTATTAAA AGCAGTAGGTAGGTTGTGCCAGTATTTTTTCAGCCAGTAAGCATATACAGTTAACTTATATAATTAAAAATTGGTTTAAGATAGTGATTA AAAATACCTGAATATTATGTTAAAAGTATACAATCATTGTTTCTGTAATGATGATGGGTATTCTGCTTCTTGTTTTTCATTGTAATTACA GGGGAAGATTGTTTTTGAAAATGTATATTGCCATGCTTTTGGGGTAAGCAGTAATGTGAAAAGAAAAAAGCATTATGTTATTGTATGAAA TATAAGTGTTCAGATTTGTTTTGTCTGGGGTGTTGCCTAAGAATACCCTAAAGCTATGGCTGTTACTGCATTGAAATCTTTTTTTTTTTT AATAGTAGCCATATGTTATTAGTGGAGTACTTTATATTTGACATTAAAGTGAAGAAGAAGAGTAGTACTTCACTTTTAGGTTTTTAGTAG TGAAAGATAAAATTGGAAAAATAGGGAAAGAGCATAGGGAGGAATAGAATGGAAGTCAAGTAAATAAAAAACTACAACCTGACAGTTTTT TAAATCACTTTGAAAAGTACATTACTTTTATCAAAGAGTTTCTAATTAAGGCAAACTATGCATTATGCCAAATATTAAGAACATTTTAAA AATGGATTGTGATACTGTTTATTTCTTTAATTATATAATTTGCAATTTTCTGTATTATAAGTGCTACCAGGATTCTAGATAGTTGATCTT ACATATTCAGATAGTATAGTTTACTCTTATAATTACCCGTTACGTTATCTCTAAAAGTAGTTTGATCTGTGCCTTTAACTTTTAGAATTC ATCTTTTGACTTGTTTGCCACTGTAGAGTTTTCAGTTTTCTCTGTAGATTCAGTGTGACAAAGAGGGAATACATAATTTGTGACCATTTA AGATGCTGATATTTTCTGGAAAAGGATATAGATAGTAGTAGTGACCCGCAGGAGCCTCACAATAATGTCTAAAGATATAAACTGAGTAGA TCCCTAAGTACTCTTCTCTAAATTATAAAATGCATTACCTAGGCTTTAATAGTTAAAAGCTGGAATTTATTGAACCGCATCTACTTGATT TCATAATATGCATTGATTTTAGTATGTTGCTGTTCTGTTATCTGTAATCAACTATAACAGAGTAATATATTTGGTGTTCTGGACCAAAAT TCGTGCTACACATATGTCTGATGGCCTTTACCTTTTCAAGAAAACAGTTGCAATTTTGAGCAAAATTTTCCTAGTTGTAATATTTTAATA GTGTTATGTATTGGAAAAAATTTAGAAATACTCCTAAGAGTTTTCAATTTCAAGCAGAAATGCTTCTCTTCTAAATAAATACCACTTAAT TGATAGACCTTTAGCAGTTCTTGTGCTATCTAGGATTTATACATTTTTGCTTTTCTGGAAAACTGCTTTGGCGCATTAACCTTTCTACTG CAACATTTTCTCTTCAGTAGATATATGAGTAAACATGATGAGTTAATGTTACACAGCATACCCAGTTAGGTCTCTTATTCTTAAAGCATC TTTCTTTAGAAGTCTGCACATATTTTCAAATGCATCATATTAAAGGCACAAGTCAAGAGGAGGTGGAGTTGCCTACTTCAGTGGCCTTTA TTCCCACTATACCAGTTCTCAGTCTTGATTTTGATACTTTCTGGCAACTGTATCATCTCTTCACTATCACGTATTTTAAGAAAAAGCTAA GGTGATTTCTTTACATTTGAACATGTGTAGATCAATGAGAGAATGGTGAGGGATAGCAAGGATAAAGTATAATGTTGAAAAGTAGAAAGA AGTGGTATCTGCTAAACTCTAGCTTTAGTAGCAAGCTATTTTAAGGAAATCATTGTATGTGGTACTTCCTAGAAATATGAAAGTTCCTCA TTTTGTATTTAATTATGTAAGAAAATGTTCTAGGAAAAGAATAAAAAACATATATTGTCAAAGTGCCCTTTGGTAGTGCTCCCAAATGGT AGTAACTATTGGTCTCTAGTATATACTCCTCAAATATCTTTTTGCTATGTATTAATATATCTATATGTTTACATATAGAAATACATAGTG TTGTGGGTTTTAAATTTTCACATAAATTGTGTCTTACCCATGTGTTTTGCCATTTGCCTTTTCTCTTGCCAACGTGTCTAGGAGCTCTTT GGTAAATACAGACTTTTTCATTTTATTTCCTCCCACATTTCTATGGATGTGTCTTGCCTTTTTCTTTTTTTTTTCTTTCTTTTTTTCTTT >In-frame_ARHGEF11_ENST00000361409_chr1_157014091_-_SHC1_ENST00000368445_chr1_154942675_-_8002nt AATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCAC TGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAA GTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTA CTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAG TTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTT TGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAG AGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGTCCTGAGAGCTGGAGGAGAAAGGATTCT ATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCAAAGCTACAGGATTCTGG AACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGAGGCTCCACGTTGGGCGGGGATGGGGCCTGAAAC TGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCCCAGGACTTCTGTGACTCCTGGGCCACAGAGGTCCAACCAGG CTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCAGGGGGGCCAGGCTGGGCAGCAGCCCCTCTTTCACCTCAACT ATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGTCTCTGTCATCGCTGGAGGAAGGGGCTTCTGGGTCCACCCCC CCGGAGGAGCTGCCTTCCCCATCAGCTTCATCCCTGGGGCCCATCCTGCCTCCTCTGCCTGGGGACGATAGTCCCACTACCCTGTGCTCC TTCTTCCCCCGGATGAGCAACCTGAGGCTGGCCAACCCGGCTGGGGGGCGCCCAGGGTCTAAGGGGGAGCCAGGAAGGGCAGCTGATGAT GGGGAGGGGATCGTAGGGGCAGCCATGCCAGACTCAGGCCCCCTACCCCTCCTCCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGC AGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCAT CCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGGTTCGGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGAC TTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAG CCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGC CTCAACCTCATGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGGACACA GCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGCCTGCCACATTCTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTC ATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCACCCCTCATGACAGGATGGCT GGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCCCTTG GGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTG GGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGCAGAGAG CTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATC AATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCT GAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTA CGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGT GTGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGTCAGCCGGGAACTGCAAGGCGAGGTGTACAGATTA TTGATGATGAACCTCAAGCCCAGACCAGTGGTGGAGGGTGCTGTTCTTCTGGATAACTGTTCACGCCTAAGAAATTAAAAGACAGAACAA AACTGTGGATCATTGCCCTCAACATGAAGACTGCCATATTCCAAGTCACATTATTTTACCAATGGAATTATAGAATTAACAGTATTTTAA ATTACGTTTATAACACTGCAGAGACCTTAAGTGCTAAACTTAGTGGAGTTTGTGACCAGAGAATTGGCATTTTCTACAAATGTTTTTTTT TGTTTTTTTTTTGTTTTTTTTTGTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCACTGGCTTGATCTCGGCTCAC TGCAAGCTCCACCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTATAGGCGCCCACCACGACGCCCGGCTA ATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAGGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCT CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTACAAATGTTAACAAAGCAATTACCAATGGCCTTTTTACATATTTTT TCTTTAATGAGGAATAATATGCATGTAGAAAAGACCTACTTAAAGTCTTCATTTATATTCTTTCAAATCAAATCTTTATTTAATAACTTA TATATGTTGTTGGAATGGTTACATTTTTGCAGCCCTTTGTATTTTGTGGTAGTTGAAATTGTATCACTTCTAAACAGCAAACTGTTTTTG TTTTTAATTAGCAGATATCTGAAGTACTATTTTTGCAGGGTTTGCACAGGCCCGTAACTGTCTACTACTTTGATATAATCTGTATACATC CTGTATGCTGAGCTGGTAAAATACATTGTAAATTACATATTAAATATTTTATCTGCTTTTACAAGCGCAAGGTGCAAAAATATATACAAT AGTCTCATTGATGACTGTAAAGTGAATTAACATTTGGTGATTATGCCTAGCTTTTTTGACTAATATAAAGATCATAGCTCCCCTTCACTT CTGTCTTAACTTGAACATGGCGTGTTTAAATTTTCATACATACTTTACTTGAATTATTGCTGTTGTCACATATTTTTGCCTCTGTGAGTT CATCTGATGATTGAGCAGTAGCATTTGCCTTTTGGGTTTTTTGTTTGTTATTATAGAAGAGATGACTTCTGCTGATTTTGCTTTAGAATG GTTACCTTAGAAGAATTTGGGTGGCTCATGTTGAATTTCACTTCTGCAATAGCTTTCATTTTCTCATAGGCTTTATAAGAGATGGGTTCA GTGGTATGAGCAGAGGAAGAGATCCCAGATAGTAGCCAGTTAACCAAGACTCATTCATATAGCACGTAGTTTATGTTCCTGAGGCAGCAC TTTTAGATCCTTTGTGAGCAAGTTCTATTTGTTCATTGCTTGCCAGAGATGAACACAGAATGTTCTGTTTCATTTTACAAGAACTATCCT GAGTTTCTGTGGATGGAAACATTACATGTAATGCAGATATAGTGAACACTGGAAAGATTTATTAAAGAATTATATTTGTGTATACTTTAT AAATTAGTCCCTCATTAGATTTTTTTTTCTTAAGCATAAGACTGAACTTAAATGTGTTAATTTTAGTAGAATCAGGCACTGCTCGCAGAA GGAACACAGATTGTAGAGATTAACATAAATTGTTCTTGTTCTAATATATATATTTTTTCATTTCTGTCGTGCTTGGAAAACTAGTAAATA TTATGTCTAAGATAAAATGGAATGGCCCCTGGATTTACTTCTTATAAGAAGCAGTAGTATGTAATAAAGCTATTAGCATGAGCAATTAAG AGGCTATAAAGAGATTATAGTTACAAAAGAAATACTGCCATATTTTTAAGTTAATAACTTAAACCTTCTCAAATGGGTTAAAAGTTGAAT GAATTGACACCCTGATGTTATGATGTTGGAATTTTAACTTAAACTGGGAGGCATTCTGTGAGCCTTCACTTTACCTTCTTTAATTATTGT CCTTGCTAAACTCAACACAGACTTTTCTGTTATGTGTTTTTGAGGAAGTTGGGGTGGGAAGAGTCAGGGAGATAAGCTAAAATTGTCTTC TTTTATGGGGTAATTGTACTCTGTAGTCTCTTGGTTTCCTGTGAAGTTAGTATTTATGTGGGGGTGGGGGAAGGTAGCAAGAATCATGGG TATCACGGTACTTTGTTTTTGACCTCCTGGCTCTTTCAGACAGAGTGAAGAAAGCTTTTCCATTCTTACTGTTGTAGAAGTAGATAGGAA ATAAGCTTTTCTCATTACAGTGAAATATGTTTTAAAAACTAGAGTAGCTGGGCACAGAGGCATGCATTTGTAGGGCCAGCTACTTGGGAG AGTGAGGCAGGAGGATCACTTGAGGCCAGGATTTCAAATCCAGCCTAGGTAACACTGAGACCTCCATCTCGTAAAAGGCACAAAAACTAG TTAGAGATGAAATTGAGCTTTATTTTAAAAAAACGTTCTAAAGCCTGATAATTGGAGAGCTATACTTCAGCTTTTCATCCTACTTTAATG AAACAGCTAGATAGGAACCTCTGCTCCAGAATTGCCAGATAATTATTGGTGGGTCATAACTATTCTTCATATTTTTTTTTTCTTTTTTCT CCTTTGGTTTCTGTGTTATCTTTCTTAACCTCACGTATTTCTTTATCCTTTTTAGTGGGGGCCTGTAATTGAGGCTAATTCAATAGCAAC AATAGACAACATGATATGGCTGCTGTCACTTTGAAACCCAAAAGGTCTTTGGGTAGGAATAGAGTAATGAAAGAGGACCAGTCAACTTCA GTATATATACAAAGGAAAGACAAAGAGATGATAAACCAAGGCTGAGGAAATTTTTCTGATGCTTTCTTCATTTCTCTAATATACCTTTTG CATTCTTTTTCTGATAATTGTGCTATTAGGCAGAAGACACAAGTTACCACGTTGTGTATTAAAAGCAGTAGGTAGGTTGTGCCAGTATTT TTTCAGCCAGTAAGCATATACAGTTAACTTATATAATTAAAAATTGGTTTAAGATAGTGATTAAAAATACCTGAATATTATGTTAAAAGT ATACAATCATTGTTTCTGTAATGATGATGGGTATTCTGCTTCTTGTTTTTCATTGTAATTACAGGGGAAGATTGTTTTTGAAAATGTATA TTGCCATGCTTTTGGGGTAAGCAGTAATGTGAAAAGAAAAAAGCATTATGTTATTGTATGAAATATAAGTGTTCAGATTTGTTTTGTCTG GGGTGTTGCCTAAGAATACCCTAAAGCTATGGCTGTTACTGCATTGAAATCTTTTTTTTTTTTAATAGTAGCCATATGTTATTAGTGGAG TACTTTATATTTGACATTAAAGTGAAGAAGAAGAGTAGTACTTCACTTTTAGGTTTTTAGTAGTGAAAGATAAAATTGGAAAAATAGGGA AAGAGCATAGGGAGGAATAGAATGGAAGTCAAGTAAATAAAAAACTACAACCTGACAGTTTTTTAAATCACTTTGAAAAGTACATTACTT TTATCAAAGAGTTTCTAATTAAGGCAAACTATGCATTATGCCAAATATTAAGAACATTTTAAAAATGGATTGTGATACTGTTTATTTCTT TAATTATATAATTTGCAATTTTCTGTATTATAAGTGCTACCAGGATTCTAGATAGTTGATCTTACATATTCAGATAGTATAGTTTACTCT TATAATTACCCGTTACGTTATCTCTAAAAGTAGTTTGATCTGTGCCTTTAACTTTTAGAATTCATCTTTTGACTTGTTTGCCACTGTAGA GTTTTCAGTTTTCTCTGTAGATTCAGTGTGACAAAGAGGGAATACATAATTTGTGACCATTTAAGATGCTGATATTTTCTGGAAAAGGAT ATAGATAGTAGTAGTGACCCGCAGGAGCCTCACAATAATGTCTAAAGATATAAACTGAGTAGATCCCTAAGTACTCTTCTCTAAATTATA AAATGCATTACCTAGGCTTTAATAGTTAAAAGCTGGAATTTATTGAACCGCATCTACTTGATTTCATAATATGCATTGATTTTAGTATGT TGCTGTTCTGTTATCTGTAATCAACTATAACAGAGTAATATATTTGGTGTTCTGGACCAAAATTCGTGCTACACATATGTCTGATGGCCT TTACCTTTTCAAGAAAACAGTTGCAATTTTGAGCAAAATTTTCCTAGTTGTAATATTTTAATAGTGTTATGTATTGGAAAAAATTTAGAA ATACTCCTAAGAGTTTTCAATTTCAAGCAGAAATGCTTCTCTTCTAAATAAATACCACTTAATTGATAGACCTTTAGCAGTTCTTGTGCT ATCTAGGATTTATACATTTTTGCTTTTCTGGAAAACTGCTTTGGCGCATTAACCTTTCTACTGCAACATTTTCTCTTCAGTAGATATATG AGTAAACATGATGAGTTAATGTTACACAGCATACCCAGTTAGGTCTCTTATTCTTAAAGCATCTTTCTTTAGAAGTCTGCACATATTTTC AAATGCATCATATTAAAGGCACAAGTCAAGAGGAGGTGGAGTTGCCTACTTCAGTGGCCTTTATTCCCACTATACCAGTTCTCAGTCTTG ATTTTGATACTTTCTGGCAACTGTATCATCTCTTCACTATCACGTATTTTAAGAAAAAGCTAAGGTGATTTCTTTACATTTGAACATGTG TAGATCAATGAGAGAATGGTGAGGGATAGCAAGGATAAAGTATAATGTTGAAAAGTAGAAAGAAGTGGTATCTGCTAAACTCTAGCTTTA GTAGCAAGCTATTTTAAGGAAATCATTGTATGTGGTACTTCCTAGAAATATGAAAGTTCCTCATTTTGTATTTAATTATGTAAGAAAATG TTCTAGGAAAAGAATAAAAAACATATATTGTCAAAGTGCCCTTTGGTAGTGCTCCCAAATGGTAGTAACTATTGGTCTCTAGTATATACT CCTCAAATATCTTTTTGCTATGTATTAATATATCTATATGTTTACATATAGAAATACATAGTGTTGTGGGTTTTAAATTTTCACATAAAT TGTGTCTTACCCATGTGTTTTGCCATTTGCCTTTTCTCTTGCCAACGTGTCTAGGAGCTCTTTGGTAAATACAGACTTTTTCATTTTATT |
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FusionGenePPI for ARHGEF11_SHC1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGEF11 | PLXNB3, PLXNB1, PLXNB2, RHOA, GNA13, GNA12, CDC42, ELAVL1, ARRB2, GSK3A, GSK3B, TRMT61A, PAK4, NTRK1, ARAP2, RFXANK, PAK7, RHOC, TRIM25 | SHC1 | FLT1, DDR2, PTPN12, MAPKAPK2, CALCOCO2, EGFR, ERBB2, ERBB3, ERBB4, PIK3R1, DOK1, DOK2, INPP5D, PLSCR1, LRP1, GRB2, CDH5, KDR, IL2RB, ABL1, INPPL1, CD22, IL4R, PLCG2, ITGB4, PTK2, EPHA2, PLCG1, CBLB, CEACAM1, CSF3R, PRKCD, ALK, FLT4, SOS1, SOS2, RET, CSF2RB, IL2RG, IGF1R, GAB2, SHCBP1, DAG1, NTRK1, ZAP70, PAG1, EPOR, VAV3, CSK, AP2A2, NTRK2, NTRK3, ESR1, APP, NGFR, LYN, CBL, EPS8, PDGFRB, CRKL, RAPGEF1, MAPK1, STAT5A, STAT5B, GH1, JAK2, GHR, MET, PIK3C2B, CALD1, MST1R, DDR1, IL6ST, INSR, FCGR2B, HIF1A, HMOX2, OSGEP, CBLC, NUDT21, MRPL44, ILK, FAM118B, SUV39H2, DUSP23, MAPK6, PRKRA, GEMIN7, C11orf58, CSF1R, LCP2, SH2B2, LRRK1, GAB1, PIK3R2, SPTBN1, SPTAN1, USP9X, AP2A1, KRT1, HSPA8, MYH10, KRT10, KRT9, KRT2, TUBB, TUBB4B, TUBA1B, TUBA1C, TUBA1A, AP2B1, USP9Y, TUBB2B, ACACA, KRT5, ACTN4, HSPA1B, SPTA1, TUBB3, KRT6A, FASN, HSPA5, MYH9, ACTB, CAD, IQGAP1, TUBA8, PSTPIP2, KRT14, MYO1D, HSPA9, HSPA1L, KRT16, ACTA1, TUBB6, HSP90AB1, HSPA6, MYH11, ACLY, RUVBL2, EEF1A1P5, KRT3, UBASH3B, DNM2, HSP90AA1, CRK, RAB3GAP2, MYH14, PRKDC, KRT17, AP2M1, IKBKAP, TUBAL3, RUVBL1, BCR, CORO1C, TIMM50, PRMT5, SEC16A, KRT77, DNAJA2, PPP1R9B, TUBA4B, MYO1C, KRT4, KRT13, DNAJA1, IARS, IGHG1, S100A8, RPS19, ATAD3B, CCT2, AIFM1, VARS, S100A9, HNRNPH1, ARAP1, CLTC, USP15, PRDX1, TEC, DDX5, HAX1, CCT6A, DDB1, S100A7, ANXA2, ERRFI1, MOV10, NXF1, RFFL, CLIC4, MAT1A, PLS3, PSPH, PPP1R8, RMDN1, STXBP1, ARHGAP32, CEP170, SCLT1, XPO1, TRIM15, CDC5L, ACTG1, ARHGEF5, GFAP, HNRNPU, LGALS3BP, SHC1, PRSS3, HSPA1A, HNRNPA2B1, ITGAV, ITGB3, ITGB1, KRAS, LTK, SHC2, OXT, RASAL2, CORO2B, PEAK1, GAREM, CDC25C, AMD1, AP1B1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGEF11_SHC1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGEF11_SHC1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGEF11 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | SHC1 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | SHC1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |