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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25106

FusionGeneSummary for NUDT3_CHD3

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT3_CHD3
Fusion gene ID: 25106
HgeneTgene
Gene symbol

NUDT3

CHD3

Gene ID

11165

1107

Gene namenudix hydrolase 3chromodomain helicase DNA binding protein 3
SynonymsDIPP|DIPP-1|DIPP1Mi-2a|Mi2-ALPHA|ZFH
Cytomap

6p21.31

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiondiphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3chromodomain-helicase-DNA-binding protein 3ATP-dependent helicase CHD3CHD-3hZFHmi-2 autoantigen 240 kDa proteinzinc finger helicasezinc-finger helicase (Snf2-like)
Modification date2018052320180522
UniProtAcc

O95989

Q12873

Ensembl transtripts involved in fusion geneENST00000607016, ENST00000380358, 
ENST00000358181, ENST00000330494, 
ENST00000570758, 
Fusion gene scores* DoF score13 X 9 X 7=8198 X 9 X 4=288
# samples 1610
** MAII scorelog2(16/819*10)=-2.35579154675365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT3 [Title/Abstract] AND CHD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUDT3

GO:0071544

diphosphoinositol polyphosphate catabolic process

10585413

TgeneCHD3

GO:0007051

spindle organization

17626165

TgeneCHD3

GO:0007098

centrosome cycle

17626165


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF737506NUDT3chr6

34261287

-CHD3chr17

7807291

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000607016ENST00000380358NUDT3chr6

34261287

-CHD3chr17

7807291

-
intron-3CDSENST00000607016ENST00000358181NUDT3chr6

34261287

-CHD3chr17

7807291

-
intron-3CDSENST00000607016ENST00000330494NUDT3chr6

34261287

-CHD3chr17

7807291

-
intron-intronENST00000607016ENST00000570758NUDT3chr6

34261287

-CHD3chr17

7807291

-

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FusionProtFeatures for NUDT3_CHD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT3

O95989

CHD3

Q12873

Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4(bisdiphosphoinositol tetrakisphosphate), suggesting that it mayplay a role in signal transduction. InsP6 (inositolhexakisphophate) is not a substrate. Acts as a negative regulatorof the ERK1/2 pathway. Also able to catalyze the hydrolysis ofdinucleoside oligophosphates, with Ap6A and Ap5A being thepreferred substrates. The major reaction products are ADP and p4afrom Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}. Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. Required for anchoring centrosomal pericentrin in bothinterphase and mitosis, for spindle organization and centrosomeintegrity. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDT3_CHD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT3_CHD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDT3_CHD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDT3_CHD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHD3C0036920Sezary Syndrome1CTD_human