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Fusion gene ID: 25086 |
FusionGeneSummary for NUDT16_PARG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUDT16_PARG | Fusion gene ID: 25086 | Hgene | Tgene | Gene symbol | NUDT16 | PARG | Gene ID | 131870 | 8505 |
| Gene name | nudix hydrolase 16 | poly(ADP-ribose) glycohydrolase | |
| Synonyms | - | PARG99 | |
| Cytomap | 3q22.1 | 10q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | U8 snoRNA-decapping enzymeIDP phosphataseIDPaseU8 snoRNA-binding protein H29Kinosine diphosphate phosphatasem7GpppN-mRNA hydrolasenucleoside diphosphate-linked moiety X motif 16nudix (nucleoside diphosphate linked moiety X)-type motif 16nudix moti | poly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96DE0 | Q86W56 | |
| Ensembl transtripts involved in fusion gene | ENST00000537561, ENST00000359850, ENST00000521288, ENST00000502852, | ENST00000402038, ENST00000492350, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 6 X 4=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUDT16 [Title/Abstract] AND PARG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUDT16 | GO:0006402 | mRNA catabolic process | 21070968|21337011 |
| Hgene | NUDT16 | GO:0016077 | snoRNA catabolic process | 15053875|17567574|18820299|21337011 |
| Hgene | NUDT16 | GO:0046709 | IDP catabolic process | 20385596 |
| Hgene | NUDT16 | GO:1901639 | XDP catabolic process | 20385596 |
| Tgene | PARG | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA697471 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000537561 | ENST00000402038 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000537561 | ENST00000492350 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000359850 | ENST00000402038 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000359850 | ENST00000492350 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000521288 | ENST00000402038 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000521288 | ENST00000492350 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000502852 | ENST00000402038 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
| 5CDS-intron | ENST00000502852 | ENST00000492350 | NUDT16 | chr3 | 131101162 | + | PARG | chr10 | 51314451 | - |
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FusionProtFeatures for NUDT16_PARG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUDT16 | PARG |
| RNA-binding and decapping enzyme that catalyzes thecleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is requiredfor the accumulation of mature 5.8S and 28S rRNA. Hasdiphosphatase activity and removes m7G and/or m227G caps from U8snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also thecleavage of the cap structure on mRNAs. Does not hydrolyze capanalog structures like 7-methylguanosine nucleoside triphosphate(m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but withless efficiencies. Has broad substrate specificity with manganeseor cobalt as cofactor and can act on various RNA species. Binds tothe U8 snoRNA; metal is not required for RNA-binding. May play arole in the regulation of snoRNAs and mRNAs degradation. Acts alsoas a phosphatase; hydrolyzes the non-canonical purine nucleotidesinosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) aswell as guanosine diphosphate (GDP), deoxyguanosine diphosphate(dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) anddeoxyinosine triphosphate (ITP) to their respective monophosphatederivatives and does not distinguish between the deoxy- and riboseforms (PubMed:20385596, PubMed:26121039). The order of activitywith different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP= dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP.Participates in the hydrolysis of dIDP/IDP and probably excludesnon-canonical purines from RNA and DNA precursor pools, thuspreventing their incorporation into RNA and DNA and avoidingchromosomal lesions (PubMed:20385596).{ECO:0000269|PubMed:15053875, ECO:0000269|PubMed:17567574,ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:20385596,ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:21337011,ECO:0000269|PubMed:26121039}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUDT16_PARG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUDT16_PARG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUDT16_PARG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUDT16_PARG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUDT16 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | PARG | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
| Tgene | PARG | C0752351 | Embryo Loss | 1 | CTD_human |
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