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Fusion gene ID: 25081 |
FusionGeneSummary for NUDT10_TTC37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUDT10_TTC37 | Fusion gene ID: 25081 | Hgene | Tgene | Gene symbol | NUDT10 | TTC37 | Gene ID | 170685 | 9652 |
| Gene name | nudix hydrolase 10 | tetratricopeptide repeat domain 37 | |
| Synonyms | APS2|DIPP3-alpha|DIPP3a | KIAA0372|Ski3|THES | |
| Cytomap | Xp11.22 | 5q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | diphosphoinositol polyphosphate phosphohydrolase 3-alphadiadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alphadiadenosine hexaphosphate hydrolase (AMP-forming)nucleoside diphosphate-linked moiety X motif 10nudix (nucleoside diphosphate linked moiet | tetratricopeptide repeat protein 37SKI3 homologTPR repeat protein 37thespintricho-hepatic-enteric syndrome protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NFP7 | Q6PGP7 | |
| Ensembl transtripts involved in fusion gene | ENST00000376006, ENST00000356450, | ENST00000358746, ENST00000515176, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUDT10 [Title/Abstract] AND TTC37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AU125362 | NUDT10 | chrX | 51079353 | + | TTC37 | chr5 | 94890681 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000376006 | ENST00000358746 | NUDT10 | chrX | 51079353 | + | TTC37 | chr5 | 94890681 | - |
| 3UTR-intron | ENST00000376006 | ENST00000515176 | NUDT10 | chrX | 51079353 | + | TTC37 | chr5 | 94890681 | - |
| 3UTR-5UTR | ENST00000356450 | ENST00000358746 | NUDT10 | chrX | 51079353 | + | TTC37 | chr5 | 94890681 | - |
| 3UTR-intron | ENST00000356450 | ENST00000515176 | NUDT10 | chrX | 51079353 | + | TTC37 | chr5 | 94890681 | - |
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FusionProtFeatures for NUDT10_TTC37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUDT10 | TTC37 |
| Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that itmay play a role in signal transduction. Also able to catalyze thehydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5Abeing the preferred substrates. The major reaction products areADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able tohydrolyze 5-phosphoribose 1-diphosphate.{ECO:0000269|PubMed:12105228}. | Component of the SKI complex which is thought to beinvolved in exosome-mediated RNA decay and associates withtranscriptionally active genes in a manner dependent on PAF1complex (PAF1C). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUDT10_TTC37 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUDT10_TTC37 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUDT10_TTC37 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUDT10_TTC37 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TTC37 | C1857276 | Trichohepatoenteric Syndrome | 1 | ORPHANET;UNIPROT |
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