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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25074

FusionGeneSummary for NUDCD3_NUDCD3

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDCD3_NUDCD3
Fusion gene ID: 25074
HgeneTgene
Gene symbol

NUDCD3

NUDCD3

Gene ID

23386

23386

Gene nameNudC domain containing 3NudC domain containing 3
SynonymsNudCLNudCL
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
DescriptionnudC domain-containing protein 3NudC-like proteinnudC domain-containing protein 3NudC-like protein
Modification date2018052320180523
UniProtAcc

Q8IVD9

Q8IVD9

Ensembl transtripts involved in fusion geneENST00000355451, ENST00000460110, 
ENST00000355451, ENST00000460110, 
Fusion gene scores* DoF score6 X 6 X 2=728 X 8 X 3=192
# samples 69
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDCD3 [Title/Abstract] AND NUDCD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA429879NUDCD3chr7

44423816

-NUDCD3chr7

44424233

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000355451ENST00000355451NUDCD3chr7

44423816

-NUDCD3chr7

44424233

-
intron-5UTRENST00000355451ENST00000460110NUDCD3chr7

44423816

-NUDCD3chr7

44424233

-
intron-3UTRENST00000460110ENST00000355451NUDCD3chr7

44423816

-NUDCD3chr7

44424233

-
intron-5UTRENST00000460110ENST00000460110NUDCD3chr7

44423816

-NUDCD3chr7

44424233

-

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FusionProtFeatures for NUDCD3_NUDCD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDCD3

Q8IVD9

NUDCD3

Q8IVD9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDCD3_NUDCD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDCD3_NUDCD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDCD3_NUDCD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDCD3_NUDCD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUDCD3C0023903Liver neoplasms1CTD_human
TgeneNUDCD3C0023903Liver neoplasms1CTD_human