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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25070

FusionGeneSummary for NUDCD3_DDIT4

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDCD3_DDIT4
Fusion gene ID: 25070
HgeneTgene
Gene symbol

NUDCD3

DDIT4

Gene ID

23386

54541

Gene nameNudC domain containing 3DNA damage inducible transcript 4
SynonymsNudCLDig2|REDD-1|REDD1
Cytomap

7p13

10q22.1

Type of geneprotein-codingprotein-coding
DescriptionnudC domain-containing protein 3NudC-like proteinDNA damage-inducible transcript 4 proteinHIF-1 responsive protein RTP801protein regulated in development and DNA damage response 1
Modification date2018052320180519
UniProtAcc

Q8IVD9

Q9NX09

Ensembl transtripts involved in fusion geneENST00000355451, ENST00000460110, 
ENST00000307365, 
Fusion gene scores* DoF score6 X 6 X 2=725 X 5 X 1=25
# samples 65
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUDCD3 [Title/Abstract] AND DDIT4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDIT4

GO:0001666

response to hypoxia

20166753

TgeneDDIT4

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ773488NUDCD3chr7

44507715

-DDIT4chr10

74035103

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000355451ENST00000307365NUDCD3chr7

44507715

-DDIT4chr10

74035103

-
intron-3UTRENST00000460110ENST00000307365NUDCD3chr7

44507715

-DDIT4chr10

74035103

-

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FusionProtFeatures for NUDCD3_DDIT4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDCD3

Q8IVD9

DDIT4

Q9NX09

Regulates cell growth, proliferation and survival viainhibition of the activity of the mammalian target of rapamycincomplex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathwaythat involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and theGTPase RHEB. Plays an important role in responses to cellularenergy levels and cellular stress, including responses to hypoxiaand DNA damage. Regulates p53/TP53-mediated apoptosis in responseto DNA damage via its effect on mTORC1 activity. Its role in theresponse to hypoxia depends on the cell type; it mediates mTORC1inhibition in fibroblasts and thymocytes, but not in hepatocytes(By similarity). Required for mTORC1-mediated defense againstviral protein synthesis and virus replication (By similarity).Inhibits neuronal differentiation and neurite outgrowth mediatedby NGF via its effect on mTORC1 activity. Required for normalneuron migration during embryonic brain development. Plays a rolein neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625,ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001,ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067,ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753,ECO:0000269|PubMed:21460850}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDCD3_DDIT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDCD3_DDIT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDCD3_DDIT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDCD3_DDIT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUDCD3C0023903Liver neoplasms1CTD_human
TgeneDDIT4C0003873Rheumatoid Arthritis1CTD_human
TgeneDDIT4C0023418leukemia1CTD_human
TgeneDDIT4C0026636Mouth Diseases1CTD_human
TgeneDDIT4C0027746Nerve Degeneration1CTD_human
TgeneDDIT4C0030567Parkinson Disease1CTD_human
TgeneDDIT4C0041696Unipolar Depression1PSYGENET
TgeneDDIT4C1269683Major Depressive Disorder1PSYGENET