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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 25048

FusionGeneSummary for NUCB1_RUVBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: NUCB1_RUVBL2
Fusion gene ID: 25048
HgeneTgene
Gene symbol

NUCB1

RUVBL2

Gene ID

4924

10856

Gene namenucleobindin 1RuvB like AAA ATPase 2
SynonymsCALNUC|NUCCGI-46|ECP-51|ECP51|INO80J|REPTIN|RVB2|TAP54-beta|TIH2|TIP48|TIP49B
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionnucleobindin-1ruvB-like 248 kDa TATA box-binding protein-interacting protein48 kDa TBP-interacting protein51 kDa erythrocyte cytosolic proteinINO80 complex subunit JRuvB (E coli homolog)-like 2TIP60-associated protein 54-betaerythrocyte cytosolic protein, 51-KD
Modification date2018052220180523
UniProtAcc

Q02818

Q9Y230

Ensembl transtripts involved in fusion geneENST00000405315, ENST00000407032, 
ENST00000485798, ENST00000263273, 
ENST00000595090, ENST00000601968, 
ENST00000598768, ENST00000413176, 
Fusion gene scores* DoF score5 X 6 X 3=902 X 2 X 2=8
# samples 92
** MAII scorelog2(9/90*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: NUCB1 [Title/Abstract] AND RUVBL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRUVBL2

GO:0043967

histone H4 acetylation

14966270

TgeneRUVBL2

GO:0043968

histone H2A acetylation

14966270

TgeneRUVBL2

GO:0090090

negative regulation of canonical Wnt signaling pathway

11080158


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLAMLTCGA-AB-2935-03ANUCB1chr19

49407711

+RUVBL2chr19

49513033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000405315ENST00000595090NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
In-frameENST00000405315ENST00000601968NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000405315ENST00000598768NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000405315ENST00000413176NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
In-frameENST00000407032ENST00000595090NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
In-frameENST00000407032ENST00000601968NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000407032ENST00000598768NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000407032ENST00000413176NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
intron-3CDSENST00000485798ENST00000595090NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
intron-3CDSENST00000485798ENST00000601968NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
intron-intronENST00000485798ENST00000598768NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
intron-intronENST00000485798ENST00000413176NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
In-frameENST00000263273ENST00000595090NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
In-frameENST00000263273ENST00000601968NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000263273ENST00000598768NUCB1chr19

49407711

+RUVBL2chr19

49513033

+
5CDS-intronENST00000263273ENST00000413176NUCB1chr19

49407711

+RUVBL2chr19

49513033

+

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FusionProtFeatures for NUCB1_RUVBL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUCB1

Q02818

RUVBL2

Q9Y230

Major calcium-binding protein of the Golgi. May have arole in calcium homeostasis (By similarity). {ECO:0000250}. Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization isthought to be critical for ATP hydrolysis and adjacent subunits inthe ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. The NuA4 complex ATPase and helicaseactivities seem to be, at least in part, contributed by theassociation of RUVBL1 and RUVBL2 with EP400. NuA4 may also play adirect role in DNA repair when recruited to sites of DNA damage.Component of a SWR1-like complex that specifically mediates theremoval of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair. Plays an essential role in oncogenic transformation byMYC and also modulates transcriptional activation by theLEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptionalactivity of ATF2. Involved in the endoplasmic reticulum (ER)-associateddegradation (ERAD) pathway where it negatively regulatesexpression of ER stress response genes.{ECO:0000269|PubMed:25652260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+21242_5181462RegionNote=O-glycosylated at one site
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+31342_5181462RegionNote=O-glycosylated at one site
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+31442_5181666RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212253_26481462Calcium binding1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212305_31681462Calcium binding2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313253_26481462Calcium binding1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313305_31681462Calcium binding2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314253_26481666Calcium binding1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314305_31681666Calcium binding2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212150_21881462Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212341_40781462Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313150_21881462Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313341_40781462Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314150_21881666Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314341_40781666Coiled coilOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212401_40781462Compositional biasNote=Poly-Gln
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313401_40781462Compositional biasNote=Poly-Gln
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314401_40781666Compositional biasNote=Poly-Gln
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212172_21881462DNA bindingOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313172_21881462DNA bindingOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314172_21881666DNA bindingOntology_term=ECO:0000255
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212240_27581462DomainEF-hand 1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212292_32781462DomainEF-hand 2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313240_27581462DomainEF-hand 1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313292_32781462DomainEF-hand 2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314240_27581666DomainEF-hand 1
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314292_32781666DomainEF-hand 2
HgeneNUCB1chr19:49407711chr19:49513033ENST00000263273+212228_32181462RegionBinds to GNAI2 and GNAI3
HgeneNUCB1chr19:49407711chr19:49513033ENST00000405315+313228_32181462RegionBinds to GNAI2 and GNAI3
HgeneNUCB1chr19:49407711chr19:49513033ENST00000407032+314228_32181666RegionBinds to GNAI2 and GNAI3
TgeneRUVBL2chr19:49407711chr19:49513033ENST00000595090+51577_84154464Nucleotide bindingNote=ATP


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FusionGeneSequence for NUCB1_RUVBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_391aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP
HGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLF

>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_327aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_391aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP
HGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLF

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_327aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_391aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP
HGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLF

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_327aa
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKGSKVGKLTL
KTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSR
TQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1173nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC
CGGTGCGAGGAAGAAGATGTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATC
CAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTC
CTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCC

>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_981nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1173nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC
CGGTGCGAGGAAGAAGATGTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATC
CAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTC
CTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCC

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_981nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1173nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC
CGGTGCGAGGAAGAAGATGTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATC
CAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTC
CTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCC

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_981nt
ATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAG
CGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGAT
GTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTC
AAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATC
ACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAG
TTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGC
ACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGG
CGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAAC
CGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCT
CACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1660nt
GCGGAAGTTATTTTTCCCCCGGCCGGCAGGGAGTTGTAGTTATCTTTGAAAGCCTTCTCTCTCTTTTGGCATAGGCGGGAAATGTGGCGT
CAAGAGGCTGGGATTCCGAGAAAGAAGCGAGGCTTTCACGAAAATGCGAGCGGCTTCGGCAAGGGGCGGGGCCGCTGGACGTGGATGAAA
GCTACAGAGCCAGCGTGGACCAATCAGACCTCTTTGGGGCGGGGCCTCTGTGGATAAGTGGGCGTGGTCTAGGGGGGAAGTCACCAAGAA
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTA
CGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGAT
CTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCT
CCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTC
AGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCAT
CCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCC
TGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGA
CCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGTGCGAGGAAGAAGATGTGGAGAT
GAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATCCAGCTCATCACAGCTGCCAGCTTGGT
GTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTA
CATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCCTGAGTTGGATGTCATCCCCCGACCCC
ACCCTGTTTTCCACCAGAGTTCTGACACTGTGACTCTGTATAAAATGGTTGGGAAGCTGCACCCACCCTGTGTATGTGTGGTTGCCCTGA

>In-frame_NUCB1_ENST00000405315_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_1427nt
GCGGAAGTTATTTTTCCCCCGGCCGGCAGGGAGTTGTAGTTATCTTTGAAAGCCTTCTCTCTCTTTTGGCATAGGCGGGAAATGTGGCGT
CAAGAGGCTGGGATTCCGAGAAAGAAGCGAGGCTTTCACGAAAATGCGAGCGGCTTCGGCAAGGGGCGGGGCCGCTGGACGTGGATGAAA
GCTACAGAGCCAGCGTGGACCAATCAGACCTCTTTGGGGCGGGGCCTCTGTGGATAAGTGGGCGTGGTCTAGGGGGGAAGTCACCAAGAA
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTA
CGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGAT
CTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCT
CCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTC
AGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCAT
CCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCC
TGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGA
CCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGGTACAGAAGTGCAGGTGGATGAC
ATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTC

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1390nt
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTA
CGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGAT
CTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCT
CCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTC
AGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCAT
CCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCC
TGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGA
CCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGTGCGAGGAAGAAGATGTGGAGAT
GAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATCCAGCTCATCACAGCTGCCAGCTTGGT
GTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTA
CATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCCTGAGTTGGATGTCATCCCCCGACCCC
ACCCTGTTTTCCACCAGAGTTCTGACACTGTGACTCTGTATAAAATGGTTGGGAAGCTGCACCCACCCTGTGTATGTGTGGTTGCCCTGA

>In-frame_NUCB1_ENST00000407032_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_1157nt
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGGCAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTA
CGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGAT
CTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCT
CCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTC
AGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCAT
CCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCC
TGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGA
CCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGGTACAGAAGTGCAGGTGGATGAC
ATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTC

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000595090_chr19_49513033_+_1339nt
AGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGC
TGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCA
GGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGG
CAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGC
CGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGG
CTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGT
CATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAA
GGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTT
CTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAG
CTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCA
GATCCTCCGCATCCGGTGCGAGGAAGAAGATGTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACT
GCGCTACGCCATCCAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGT
CTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGAC
CATGGACACCTCCTGAGTTGGATGTCATCCCCCGACCCCACCCTGTTTTCCACCAGAGTTCTGACACTGTGACTCTGTATAAAATGGTTG

>In-frame_NUCB1_ENST00000263273_chr19_49407711_+_RUVBL2_ENST00000601968_chr19_49513033_+_1106nt
AGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGC
TGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCA
GGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGGGCTCCAAGGTGGG
CAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGC
CGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGG
CTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGT
CATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAA
GGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTT
CTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAG
CTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCA
GATCCTCCGCATCCGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTAC
ATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCCTGAGTTGGATGTCATCCCCCGACCCCA


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FusionGenePPI for NUCB1_RUVBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUCB1GNAI2, KLC4, GNAI3, GNAS, HIVEP1, RBL1, SET, GNAI1, MYC, XPO1, PTGS2, CBS, CTPS2, GTF2I, METTL1, XPNPEP1, PRKDC, RAD23B, WARS, HSPA5, REL, FGL1, MMP3, FAM213B, ADCYAP1, DKKL1, MANSC1, FGF3, DDX31, EPHA1, HLA-DPA1, CYP1A1, MMP10RUVBL2DPCD, RIOK3, PON2, RUVBL1, UQCRC1, DNASE2, C2orf44, SSSCA1, PLOD2, USP7, RPS11, BCAS1, IKBKE, RGS20, NEK6, NME2, ATF2, EP400, MYC, FDFT1, PCNA, ING3, MEPCE, RPAP2, CDK7, CDK9, CCDC87, DDX42, RPAP3, TTI1, CCAR2, MATR3, PIH1D1, PCBP2, POLR2B, RFC4, SRCAP, UXT, ACTB, ACTG1, URI1, YEATS4, EFTUD2, NTPCR, ZNHIT2, PFDN6, PDRG1, POLR2E, KPNB1, HSPA5, PPP1CA, HNRNPU, RFC5, C12orf45, RPS4X, TTI2, POLR2H, PCBP1, ACTL6A, TRIM28, RQCD1, DNM2, ACTR6, NOP58, NFRKB, TFPT, DMAP1, INO80E, UCHL5, TELO2, RPL38, HSP90AA2P, ACTR5, PCBP3, ARF6, RPS2, ACTR8, HSPA1L, MLH1, PMS2, AIRE, SENP1, SENP6, CTNNB1, HDAC1, APPL1, APPL2, CTNNBIP1, HDAC2, MRGBP, SRRM2, INO80, YY1, FBL, TAF9, NUFIP1, MORF4L1, MORF4L2, EHMT2, SUV39H1, HIF1A, SREBF1, UBC, H2AFZ, INO80C, INO80B, INO80D, MCRS1, KAT5, AGO3, MME, HDAC5, SMARCAD1, SOX2, NDRG1, CENPA, HJURP, NFKB1, BCL3, FBXO25, MTOR, CUL3, CUL1, SHC1, AP2M1, UBXN6, APP, VPS72, CAD, SMARCA5, EEF1A1, POLR2A, ESR1, HINT1, LIG4, YWHAE, TERT, TERC, DKC1, FN1, VCAM1, NOS2, ERCC8, METTL18, METTL21B, RUVBL2, TBP, STOM, PAN2, SMG1, UPF1, RBM8A, BAG3, EXOSC10, YWHAQ, FBXO6, TARDBP, PPP6R2, PARK2, CDKN2A, ASNA1, PPP6R3, PLA2G4A, RPA3, RPA2, RPA1, VCP, HUWE1, LNX1, CCDC103, NXF1, BRCA1, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, SIRT6, ILK, LIMK2, TYK2, ILF2, RDM1, HIST1H2BA, PPP1R3A, STRN3, RPS6KB2, EP300, BRD2, DYNC1H1, DYNC2H1, EIF6, IPO4, AKAP8, ARHGAP1, ASS1, BRD3, CFDP1, CORO1B, GOLPH3, MCFD2, SNX1, SNX2, TMOD2, TMOD3, TUBA4A, TXLNA, USP39, NTRK1, SCARNA22, MDM2, XPO1, KPNA1, TRRAP, POLR1A, POLR3E, CRY1, CRY2, TRIM29, SNW1, CDC5L, EPC1, MBTD1, CDC73, CRBN, DERL1, EGFR, ZNHIT1, EPC2, MEAF6, BRD8, KCTD15, ACTL6B, CAMKK1, POLR3A, MYCL, CRTAC1, FOXR2, CYLD, AAR2, EAPP, MAP1B, PFDN2, PRPF8, RICTOR, SHQ1, SLC7A6OS, SNRNP200, TANGO6, TSSC4, WDR92, CHD4, IWS1, SUGP2, WAPAL, TBC1D7, TSC1, TSC2, DLD, DNM1L, HSD17B10, PDHA1, SDHA, SOD1, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUCB1_RUVBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNUCB1Q02818DB11093Calcium CitrateNucleobindin-1small moleculeapproved
HgeneNUCB1Q02818DB11348Calcium PhosphateNucleobindin-1small moleculeapproved

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RelatedDiseases for NUCB1_RUVBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUCB1C0038325Stevens-Johnson Syndrome1CTD_human