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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25023

FusionGeneSummary for NTRK3_NTRK3

check button Fusion gene summary
Fusion gene informationFusion gene name: NTRK3_NTRK3
Fusion gene ID: 25023
HgeneTgene
Gene symbol

NTRK3

NTRK3

Gene ID

4916

4916

Gene nameneurotrophic receptor tyrosine kinase 3neurotrophic receptor tyrosine kinase 3
SynonymsGP145-TrkC|TRKC|gp145(trkC)GP145-TrkC|TRKC|gp145(trkC)
Cytomap

15q25.3

15q25.3

Type of geneprotein-codingprotein-coding
DescriptionNT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor CNT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C
Modification date2018052320180523
UniProtAcc

Q16288

Q16288

Ensembl transtripts involved in fusion geneENST00000394480, ENST00000557856, 
ENST00000357724, ENST00000355254, 
ENST00000360948, ENST00000542733, 
ENST00000558676, ENST00000317501, 
ENST00000558306, ENST00000540489, 
ENST00000394480, ENST00000557856, 
ENST00000357724, ENST00000355254, 
ENST00000360948, ENST00000542733, 
ENST00000558676, ENST00000317501, 
ENST00000558306, ENST00000540489, 
Fusion gene scores* DoF score7 X 7 X 3=1479 X 7 X 9=567
# samples 1120
** MAII scorelog2(11/147*10)=-0.418312631311705
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/567*10)=-1.5033487351675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NTRK3 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNTRK3

GO:0000187

activation of MAPK activity

23027130

HgeneNTRK3

GO:0001933

negative regulation of protein phosphorylation

23027130

HgeneNTRK3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

HgeneNTRK3

GO:0008284

positive regulation of cell proliferation

23027130

HgeneNTRK3

GO:0010628

positive regulation of gene expression

23027130

HgeneNTRK3

GO:0030335

positive regulation of cell migration

23027130

HgeneNTRK3

GO:0032148

activation of protein kinase B activity

23027130

HgeneNTRK3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

HgeneNTRK3

GO:0050927

positive regulation of positive chemotaxis

23027130

HgeneNTRK3

GO:0090630

activation of GTPase activity

23027130

HgeneNTRK3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130

TgeneNTRK3

GO:0000187

activation of MAPK activity

23027130

TgeneNTRK3

GO:0001933

negative regulation of protein phosphorylation

23027130

TgeneNTRK3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

TgeneNTRK3

GO:0008284

positive regulation of cell proliferation

23027130

TgeneNTRK3

GO:0010628

positive regulation of gene expression

23027130

TgeneNTRK3

GO:0030335

positive regulation of cell migration

23027130

TgeneNTRK3

GO:0032148

activation of protein kinase B activity

23027130

TgeneNTRK3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

TgeneNTRK3

GO:0050927

positive regulation of positive chemotaxis

23027130

TgeneNTRK3

GO:0090630

activation of GTPase activity

23027130

TgeneNTRK3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL134171NTRK3chr15

88521948

+NTRK3chr15

88521840

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394480ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000394480ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000394480ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000557856ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000557856ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000357724ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000357724ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000355254ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000355254ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000360948ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000360948ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000542733ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000542733ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000558676ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558676ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000317501ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000317501ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000558306ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000558306ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000394480NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000557856NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000357724NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000355254NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000360948NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000542733NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000558676NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-3UTRENST00000540489ENST00000317501NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000558306NTRK3chr15

88521948

+NTRK3chr15

88521840

-
intron-intronENST00000540489ENST00000540489NTRK3chr15

88521948

+NTRK3chr15

88521840

-

Top

FusionProtFeatures for NTRK3_NTRK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NTRK3

Q16288

NTRK3

Q16288

Receptor tyrosine kinase involved in nervous system andprobably heart development. Upon binding of its ligandNTF3/neurotrophin-3, NTRK3 autophosphorylates and activatesdifferent signaling pathways, including the phosphatidylinositol3-kinase/AKT and the MAPK pathways, that control cell survival anddifferentiation. {ECO:0000269|PubMed:25196463}. Receptor tyrosine kinase involved in nervous system andprobably heart development. Upon binding of its ligandNTF3/neurotrophin-3, NTRK3 autophosphorylates and activatesdifferent signaling pathways, including the phosphatidylinositol3-kinase/AKT and the MAPK pathways, that control cell survival anddifferentiation. {ECO:0000269|PubMed:25196463}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NTRK3_NTRK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NTRK3_NTRK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NTRK3_NTRK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NTRK3_NTRK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNTRK3C0036341Schizophrenia3PSYGENET
HgeneNTRK3C0041696Unipolar Depression2PSYGENET
HgeneNTRK3C1269683Major Depressive Disorder2PSYGENET
HgeneNTRK3C0014175Endometriosis1CTD_human
HgeneNTRK3C0017638Glioma1CTD_human
HgeneNTRK3C0038220Status Epilepticus1CTD_human
HgeneNTRK3C0525045Mood Disorders1PSYGENET
TgeneNTRK3C0036341Schizophrenia3PSYGENET
TgeneNTRK3C0041696Unipolar Depression2PSYGENET
TgeneNTRK3C1269683Major Depressive Disorder2PSYGENET
TgeneNTRK3C0014175Endometriosis1CTD_human
TgeneNTRK3C0017638Glioma1CTD_human
TgeneNTRK3C0038220Status Epilepticus1CTD_human
TgeneNTRK3C0525045Mood Disorders1PSYGENET