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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25017

FusionGeneSummary for NTRK2_LAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: NTRK2_LAP3
Fusion gene ID: 25017
HgeneTgene
Gene symbol

NTRK2

LAP3

Gene ID

4915

51056

Gene nameneurotrophic receptor tyrosine kinase 2leucine aminopeptidase 3
SynonymsEIEE58|GP145-TrkB|OBHD|TRKB|trk-BHEL-S-106|LAP|LAPEP|PEPS
Cytomap

9q21.33

4p15.32

Type of geneprotein-codingprotein-coding
DescriptionBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor Bcytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
Modification date2018052320180519
UniProtAcc

Q16620

P28838

Ensembl transtripts involved in fusion geneENST00000376214, ENST00000376213, 
ENST00000395882, ENST00000304053, 
ENST00000376208, ENST00000277120, 
ENST00000323115, ENST00000359847, 
ENST00000395866, 
ENST00000226299, 
ENST00000606142, ENST00000503467, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 4 X 5=100
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NTRK2 [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DB-5278-01ANTRK2chr9

87430621

+LAP3chr4

17585225

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000376214ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000376214ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000376214ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000376213ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000376213ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000376213ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
Frame-shitENST00000395882ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
Frame-shitENST00000395882ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
5CDS-intronENST00000395882ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000304053ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000304053ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000304053ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000376208ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000376208ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000376208ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000277120ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000277120ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000277120ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000323115ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000323115ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000323115ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
Frame-shitENST00000359847ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
Frame-shitENST00000359847ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
5CDS-intronENST00000359847ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000395866ENST00000226299NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-3CDSENST00000395866ENST00000606142NTRK2chr9

87430621

+LAP3chr4

17585225

+
intron-intronENST00000395866ENST00000503467NTRK2chr9

87430621

+LAP3chr4

17585225

+

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FusionProtFeatures for NTRK2_LAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NTRK2

Q16620

LAP3

P28838

Receptor tyrosine kinase involved in the development andthe maturation of the central and the peripheral nervous systemsthrough regulation of neuron survival, proliferation, migration,differentiation, and synapse formation and plasticity. Receptorfor BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is lessefficient in activating the receptor but regulates neuron survivalthrough NTRK2. Upon ligand-binding, undergoes homodimerization,autophosphorylation and activation. Recruits, phosphorylatesand/or activates several downstream effectors including SHC1,FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlappingsignaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates theGRB2-Ras-MAPK cascade that regulates for instance neuronaldifferentiation including neurite outgrowth. Through the sameeffectors controls the Ras-PI3 kinase-AKT1 signaling cascade thatmainly regulates growth and survival. Through PLCG1 and thedownstream protein kinase C-regulated pathways controls synapticplasticity. Thereby, plays a role in learning and memory byregulating both short term synaptic function and long-termpotentiation. PLCG1 also leads to NF-Kappa-B activation and thetranscription of genes involved in cell survival. Hence, it isable to suppress anoikis, the apoptosis resulting from loss ofcell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediatecommunication between neurons and glia.{ECO:0000269|PubMed:15494731}. Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NTRK2_LAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NTRK2_LAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NTRK2NTF3, FYN, FRS2, SHC1, PLCG1, BDNF, NTF4, SHC3, GIPC1, SQSTM1, PIK3R1, SH2B1, NCK2, PTPN1, TRAF6, HSP90AA1, POLR2G, AP1B1, NMNAT1, RANBP9, TNK2, EGFRLAP3DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NTRK2_LAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNTRK2Q16620DB00321AmitriptylineBDNF/NT-3 growth factors receptorsmall moleculeapproved

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RelatedDiseases for NTRK2_LAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNTRK2C0011570Mental Depression5PSYGENET
HgeneNTRK2C0011581Depressive disorder5PSYGENET
HgeneNTRK2C0041696Unipolar Depression5PSYGENET
HgeneNTRK2C0525045Mood Disorders5PSYGENET
HgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
HgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
HgeneNTRK2C0036341Schizophrenia2PSYGENET
HgeneNTRK2C0038220Status Epilepticus2CTD_human
HgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
HgeneNTRK2C0424295Hyperactive behavior2CTD_human
HgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNTRK2C0004114Astrocytoma1CTD_human
HgeneNTRK2C0004352Autistic Disorder1CTD_human
HgeneNTRK2C0008073Developmental Disabilities1CTD_human
HgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
HgeneNTRK2C0017638Glioma1CTD_human
HgeneNTRK2C0020505Hyperphagia1CTD_human;HPO
HgeneNTRK2C0027819Neuroblastoma1CTD_human
HgeneNTRK2C0028754Obesity1CTD_human;HPO
HgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
HgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
HgeneNTRK2C0752347Lewy Body Disease1CTD_human
HgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET
HgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay1UNIPROT