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Fusion gene ID: 25017 |
FusionGeneSummary for NTRK2_LAP3 |
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Fusion gene information | Fusion gene name: NTRK2_LAP3 | Fusion gene ID: 25017 | Hgene | Tgene | Gene symbol | NTRK2 | LAP3 | Gene ID | 4915 | 51056 |
Gene name | neurotrophic receptor tyrosine kinase 2 | leucine aminopeptidase 3 | |
Synonyms | EIEE58|GP145-TrkB|OBHD|TRKB|trk-B | HEL-S-106|LAP|LAPEP|PEPS | |
Cytomap | 9q21.33 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B | cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q16620 | P28838 | |
Ensembl transtripts involved in fusion gene | ENST00000376214, ENST00000376213, ENST00000395882, ENST00000304053, ENST00000376208, ENST00000277120, ENST00000323115, ENST00000359847, ENST00000395866, | ENST00000226299, ENST00000606142, ENST00000503467, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 4 X 5=100 |
# samples | 4 | 5 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NTRK2 [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-DB-5278-01A | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000376214 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000376214 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000376214 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000376213 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000376213 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000376213 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
Frame-shift | ENST00000395882 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
Frame-shift | ENST00000395882 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
5CDS-intron | ENST00000395882 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000304053 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000304053 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000304053 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000376208 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000376208 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000376208 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000277120 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000277120 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000277120 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000323115 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000323115 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000323115 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
Frame-shift | ENST00000359847 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
Frame-shift | ENST00000359847 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
5CDS-intron | ENST00000359847 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000395866 | ENST00000226299 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-3CDS | ENST00000395866 | ENST00000606142 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
intron-intron | ENST00000395866 | ENST00000503467 | NTRK2 | chr9 | 87430621 | + | LAP3 | chr4 | 17585225 | + |
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FusionProtFeatures for NTRK2_LAP3 |
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Hgene | Tgene |
NTRK2 | LAP3 |
Receptor tyrosine kinase involved in the development andthe maturation of the central and the peripheral nervous systemsthrough regulation of neuron survival, proliferation, migration,differentiation, and synapse formation and plasticity. Receptorfor BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is lessefficient in activating the receptor but regulates neuron survivalthrough NTRK2. Upon ligand-binding, undergoes homodimerization,autophosphorylation and activation. Recruits, phosphorylatesand/or activates several downstream effectors including SHC1,FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlappingsignaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates theGRB2-Ras-MAPK cascade that regulates for instance neuronaldifferentiation including neurite outgrowth. Through the sameeffectors controls the Ras-PI3 kinase-AKT1 signaling cascade thatmainly regulates growth and survival. Through PLCG1 and thedownstream protein kinase C-regulated pathways controls synapticplasticity. Thereby, plays a role in learning and memory byregulating both short term synaptic function and long-termpotentiation. PLCG1 also leads to NF-Kappa-B activation and thetranscription of genes involved in cell survival. Hence, it isable to suppress anoikis, the apoptosis resulting from loss ofcell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediatecommunication between neurons and glia.{ECO:0000269|PubMed:15494731}. | Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NTRK2_LAP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NTRK2_LAP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NTRK2 | NTF3, FYN, FRS2, SHC1, PLCG1, BDNF, NTF4, SHC3, GIPC1, SQSTM1, PIK3R1, SH2B1, NCK2, PTPN1, TRAF6, HSP90AA1, POLR2G, AP1B1, NMNAT1, RANBP9, TNK2, EGFR | LAP3 | DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NTRK2_LAP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NTRK2 | Q16620 | DB00321 | Amitriptyline | BDNF/NT-3 growth factors receptor | small molecule | approved |
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RelatedDiseases for NTRK2_LAP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NTRK2 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | NTRK2 | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | NTRK2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | NTRK2 | C0525045 | Mood Disorders | 5 | PSYGENET |
Hgene | NTRK2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | NTRK2 | C0005586 | Bipolar Disorder | 3 | CTD_human;PSYGENET |
Hgene | NTRK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | NTRK2 | C0038220 | Status Epilepticus | 2 | CTD_human |
Hgene | NTRK2 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
Hgene | NTRK2 | C0424295 | Hyperactive behavior | 2 | CTD_human |
Hgene | NTRK2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | NTRK2 | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | NTRK2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | NTRK2 | C0008073 | Developmental Disabilities | 1 | CTD_human |
Hgene | NTRK2 | C0013415 | Dysthymic Disorder | 1 | PSYGENET |
Hgene | NTRK2 | C0017638 | Glioma | 1 | CTD_human |
Hgene | NTRK2 | C0020505 | Hyperphagia | 1 | CTD_human;HPO |
Hgene | NTRK2 | C0027819 | Neuroblastoma | 1 | CTD_human |
Hgene | NTRK2 | C0028754 | Obesity | 1 | CTD_human;HPO |
Hgene | NTRK2 | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
Hgene | NTRK2 | C0678807 | prenatal alcohol exposure | 1 | PSYGENET |
Hgene | NTRK2 | C0752347 | Lewy Body Disease | 1 | CTD_human |
Hgene | NTRK2 | C3146244 | Alcohol Related Birth Defect | 1 | PSYGENET |
Hgene | NTRK2 | C3151303 | Obesity, Hyperphagia, and Developmental Delay | 1 | UNIPROT |