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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25001

FusionGeneSummary for NTN1_RANGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NTN1_RANGAP1
Fusion gene ID: 25001
HgeneTgene
Gene symbol

NTN1

RANGAP1

Gene ID

9423

5905

Gene namenetrin 1Ran GTPase activating protein 1
SynonymsNTN1LFug1|RANGAP|SD
Cytomap

17p13.1

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionnetrin-1epididymis tissue protein Li 131Pnetrin 1, mouse, homolog ofran GTPase-activating protein 1segregation distorter homologsegregation distortion
Modification date2018052020180522
UniProtAcc

O95631

P46060

Ensembl transtripts involved in fusion geneENST00000173229, ENST00000538852, 
ENST00000546090, 
ENST00000405486, 
ENST00000356244, ENST00000455915, 
ENST00000407260, 
Fusion gene scores* DoF score3 X 2 X 3=188 X 8 X 5=320
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NTN1 [Title/Abstract] AND RANGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

TgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A7WK-01ANTN1chr17

8926708

+RANGAP1chr22

41664160

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000173229ENST00000405486NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000173229ENST00000356244NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000173229ENST00000455915NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000173229ENST00000407260NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000538852ENST00000405486NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000538852ENST00000356244NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000538852ENST00000455915NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000538852ENST00000407260NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000546090ENST00000405486NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000546090ENST00000356244NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000546090ENST00000455915NTN1chr17

8926708

+RANGAP1chr22

41664160

-
Frame-shiftENST00000546090ENST00000407260NTN1chr17

8926708

+RANGAP1chr22

41664160

-

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FusionProtFeatures for NTN1_RANGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NTN1

O95631

RANGAP1

P46060

Netrins control guidance of CNS commissural axons andperipheral motor axons. Its association with either DCC or someUNC5 receptors will lead to axon attraction or repulsion,respectively. It also serve as a survival factor via itsassociation with its receptors which prevent the initiation ofapoptosis. Involved in tumorigenesis by regulating apoptosis.{ECO:0000269|PubMed:15343335}. GTPase activator for RAN (PubMed:8146159,PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-boundRAN to GDP-bound RAN, which is essential for RAN-mediated nuclearimport and export (PubMed:8896452, PubMed:27160050). Mediatesdissociation of cargo from nuclear export complexes containingXPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).{ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050,ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NTN1_RANGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NTN1_RANGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NTN1DCC, UNC5A, NEUROG3RANGAP1UBE2I, SUMO1, RAN, RANGAP1, BABAM1, MEPCE, PMS1, TOPORS, RANBP2, ARRB2, SIRT7, USPL1, CSNK2A1, PCGF2, NXF1, PRDX6, NDUFA7, SORD, PRPF8, DYNC1LI1, EFTUD2, HUWE1, PPIF, PNPT1, NCOA6, PPIB, MMS19, SOX2, LMNA, EGFR, GNAI3, GNAI1, CCL5, SENP1, NLK, MIB1, KIAA1279, ACTR2, ACTR3, ARPC1B, ARPC2, BAG1, CALU, DBNL, EEF2K, EFTUD1, IPO11, LPP, NIF3L1, NSUN2, OSGEP, PANK4, PPP2R5D, RPRD1B, SAE1, SH3GLB1, THG1L, TP53RK, TPD52L2, TPRKB, UFM1, SENP2, CUL7, OBSL1, RNF2, UBE2E3, RCC1, C11orf58, COL4A3BP, CPSF4, EEF1G, GNL1, GTF3C3, IPO5, KDM2A, NCL, PCF11, POLR3C, RALY, CPSF1, PTBP1, U2AF2, UBR5, XPO1, RGPD2, RGPD5, RGPD6, SUB1, SUPT5H, UBR4, NTRK1, SCARNA22, NUP85, NUP107, NUP35, KPNB1, NUP153, ATP6AP2, SEH1L, MYO18A, JUN, RBPJ, FOXB1, FOXE1, FOXJ3, TMUB1, FOXL1, FOXQ1, SNW1, CDC5L, CDH1, CTDSPL2, B2M, TMEM194A, DLD, DLST, PDHA1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NTN1_RANGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NTN1_RANGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRANGAP1C0079744Diffuse Large B-Cell Lymphoma1CTD_human