|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 24989 |
FusionGeneSummary for NT5DC3_PTPRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NT5DC3_PTPRR | Fusion gene ID: 24989 | Hgene | Tgene | Gene symbol | NT5DC3 | PTPRR | Gene ID | 51559 | 5801 |
| Gene name | 5'-nucleotidase domain containing 3 | protein tyrosine phosphatase, receptor type R | |
| Synonyms | TU12B1-TY|TU12B1TY | EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ | |
| Cytomap | 12q23.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-nucleotidase domain-containing protein 3 | receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q86UY8 | Q15256 | |
| Ensembl transtripts involved in fusion gene | ENST00000392876, ENST00000465502, | ENST00000283228, ENST00000440835, ENST00000537619, ENST00000378778, ENST00000342084, ENST00000549308, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 33 X 13 X 10=4290 |
| # samples | 2 | 31 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(31/4290*10)=-3.79063752711267 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NT5DC3 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A2IZ-01A | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392876 | ENST00000283228 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| 5CDS-intron | ENST00000392876 | ENST00000440835 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| 5CDS-intron | ENST00000392876 | ENST00000537619 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| 5CDS-intron | ENST00000392876 | ENST00000378778 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| 5CDS-intron | ENST00000392876 | ENST00000342084 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| 5CDS-intron | ENST00000392876 | ENST00000549308 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-3CDS | ENST00000465502 | ENST00000283228 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-intron | ENST00000465502 | ENST00000440835 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-intron | ENST00000465502 | ENST00000537619 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-intron | ENST00000465502 | ENST00000378778 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-intron | ENST00000465502 | ENST00000342084 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
| intron-intron | ENST00000465502 | ENST00000549308 | NT5DC3 | chr12 | 104208715 | - | PTPRR | chr12 | 71158558 | - |
Top |
FusionProtFeatures for NT5DC3_PTPRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NT5DC3 | PTPRR |
| Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NT5DC3 | chr12:104208715 | chr12:71158558 | ENST00000392876 | - | 2 | 14 | 4_7 | 131 | 549 | Compositional bias | Note=Poly-Ala |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000283228 | - | 1 | 14 | 393_647 | 119 | 658 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000342084 | - | 0 | 13 | 393_647 | 7 | 546 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000378778 | - | 0 | 11 | 393_647 | 0 | 452 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000440835 | - | 0 | 10 | 393_647 | -156 | 413 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000549308 | - | 0 | 11 | 393_647 | -80 | 413 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000283228 | - | 1 | 14 | 588_594 | 119 | 658 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000342084 | - | 0 | 13 | 588_594 | 7 | 546 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000378778 | - | 0 | 11 | 588_594 | 0 | 452 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000440835 | - | 0 | 10 | 588_594 | -156 | 413 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000549308 | - | 0 | 11 | 588_594 | -80 | 413 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000283228 | - | 1 | 14 | 249_657 | 119 | 658 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000342084 | - | 0 | 13 | 22_227 | 7 | 546 | Topological domain | Extracellular |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000342084 | - | 0 | 13 | 249_657 | 7 | 546 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000378778 | - | 0 | 11 | 22_227 | 0 | 452 | Topological domain | Extracellular |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000378778 | - | 0 | 11 | 249_657 | 0 | 452 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000440835 | - | 0 | 10 | 22_227 | -156 | 413 | Topological domain | Extracellular |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000440835 | - | 0 | 10 | 249_657 | -156 | 413 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000549308 | - | 0 | 11 | 22_227 | -80 | 413 | Topological domain | Extracellular |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000549308 | - | 0 | 11 | 249_657 | -80 | 413 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000283228 | - | 1 | 14 | 228_248 | 119 | 658 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000342084 | - | 0 | 13 | 228_248 | 7 | 546 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000378778 | - | 0 | 11 | 228_248 | 0 | 452 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000440835 | - | 0 | 10 | 228_248 | -156 | 413 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:104208715 | chr12:71158558 | ENST00000549308 | - | 0 | 11 | 228_248 | -80 | 413 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NT5DC3 | chr12:104208715 | chr12:71158558 | ENST00000392876 | - | 2 | 14 | 251_259 | 131 | 549 | Region | Substrate binding |
| Tgene | PTPRR | chr12:104208715 | chr12:71158558 | ENST00000283228 | - | 1 | 14 | 22_227 | 119 | 658 | Topological domain | Extracellular |
Top |
FusionGeneSequence for NT5DC3_PTPRR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_670aa MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLCTAPGTAPDMKRYLWERYREAKRSTEELVPSIMSNLLNPDAIFSNNE MSLSDIEIYGFDYDYTLVFYSKHLHTLIFNAARDLLINEHRTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVS PINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLS LRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMS SLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKN VTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNY TIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_2010nt ATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGGCAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCG GCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCACCCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGC TACCGGGAGGCGAAGAGAAGCACAGAAGAATTGGTTCCTTCCATTATGAGCAACTTGTTGAATCCAGATGCCATTTTCTCAAACAATGAA ATGAGCCTGTCAGACATTGAAATCTATGGCTTCGATTATGATTACACCTTGGTGTTTTATTCAAAGCACCTCCACACGCTGATATTTAAT GCTGCACGGGACCTTCTCATCAATGAACACCGGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAA GGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCT CCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTA TCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTT TATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCC TTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGC ATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCT ACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGT AGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTC ACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAA GAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAAT GTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCC ATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAAT GAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTAC ACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCA GACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGC AGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGC ATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_3153nt GCAGAGCGGCGCGGCGGCGGTGGCGGCAGCAGGCAGCAGGCATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGG CAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCGGCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCAC CCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGCTACCGGGAGGCGAAGAGAAGCACAGAAGAATTGGTTCCTTCCATTATGA GCAACTTGTTGAATCCAGATGCCATTTTCTCAAACAATGAAATGAGCCTGTCAGACATTGAAATCTATGGCTTCGATTATGATTACACCT TGGTGTTTTATTCAAAGCACCTCCACACGCTGATATTTAATGCTGCACGGGACCTTCTCATCAATGAACACCGGACACTGCAAATGGATG TAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATC GCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAG TTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAG GGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTT TGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCA CATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACC CTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAG AGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGA AGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAA GTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTT TACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCT ACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACA GCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAG TTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGA AGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACA GACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCT GTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTG AGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAG ACCATCAATCTCTTGGGGTGATTAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAA GCCCATGTATGGCATGGATTGTGGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCC CAAATTATTCTGAAGGTTTTTTGATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTA TCTGCCACACAGAATGTATGTATGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGT GTTAGATGCTTTAATGTTTGCAAAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTC AGTTACCAGAATCTTGCTGCTAAAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAA ACAGTAACTATTTTATATGGAAATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCA CAATGATTGTCATTGGGTATATATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCC ACATCGTGAGTCATTTTACTTTAAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGC TAAGAAGGGATTTTTGAATATGCTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATT TTCGAGGCTCCTTATAAGGACATTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACT ACCCTCAGCAAACACTAGCTGTTCTGCTCATATATGAATTTTTAATGCAGCAATGTTGACTTTGTTTCATACTGCCAATAAACTCTTAAT |
Top |
FusionGenePPI for NT5DC3_PTPRR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NT5DC3 | ELAVL1, KIF11, EXOSC2, ZNF211, NT5DC2 | PTPRR | MAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NT5DC3_PTPRR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NT5DC3_PTPRR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PTPRR | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | PTPRR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|