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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24989

FusionGeneSummary for NT5DC3_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: NT5DC3_PTPRR
Fusion gene ID: 24989
HgeneTgene
Gene symbol

NT5DC3

PTPRR

Gene ID

51559

5801

Gene name5'-nucleotidase domain containing 3protein tyrosine phosphatase, receptor type R
SynonymsTU12B1-TY|TU12B1TYEC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

12q23.3

12q15

Type of geneprotein-codingprotein-coding
Description5'-nucleotidase domain-containing protein 3receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018052320180519
UniProtAcc

Q86UY8

Q15256

Ensembl transtripts involved in fusion geneENST00000392876, ENST00000465502, 
ENST00000283228, ENST00000440835, 
ENST00000537619, ENST00000378778, 
ENST00000342084, ENST00000549308, 
Fusion gene scores* DoF score2 X 2 X 2=833 X 13 X 10=4290
# samples 231
** MAII scorelog2(2/8*10)=1.32192809488736log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NT5DC3 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A2IZ-01ANT5DC3chr12

104208715

-PTPRRchr12

71158558

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392876ENST00000283228NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
5CDS-intronENST00000392876ENST00000440835NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
5CDS-intronENST00000392876ENST00000537619NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
5CDS-intronENST00000392876ENST00000378778NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
5CDS-intronENST00000392876ENST00000342084NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
5CDS-intronENST00000392876ENST00000549308NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-3CDSENST00000465502ENST00000283228NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-intronENST00000465502ENST00000440835NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-intronENST00000465502ENST00000537619NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-intronENST00000465502ENST00000378778NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-intronENST00000465502ENST00000342084NT5DC3chr12

104208715

-PTPRRchr12

71158558

-
intron-intronENST00000465502ENST00000549308NT5DC3chr12

104208715

-PTPRRchr12

71158558

-

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FusionProtFeatures for NT5DC3_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NT5DC3

Q86UY8

PTPRR

Q15256

Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNT5DC3chr12:104208715chr12:71158558ENST00000392876-2144_7131549Compositional biasNote=Poly-Ala
TgenePTPRRchr12:104208715chr12:71158558ENST00000283228-114393_647119658DomainTyrosine-protein phosphatase
TgenePTPRRchr12:104208715chr12:71158558ENST00000342084-013393_6477546DomainTyrosine-protein phosphatase
TgenePTPRRchr12:104208715chr12:71158558ENST00000378778-011393_6470452DomainTyrosine-protein phosphatase
TgenePTPRRchr12:104208715chr12:71158558ENST00000440835-010393_647-156413DomainTyrosine-protein phosphatase
TgenePTPRRchr12:104208715chr12:71158558ENST00000549308-011393_647-80413DomainTyrosine-protein phosphatase
TgenePTPRRchr12:104208715chr12:71158558ENST00000283228-114588_594119658RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000342084-013588_5947546RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000378778-011588_5940452RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000440835-010588_594-156413RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000549308-011588_594-80413RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000283228-114249_657119658Topological domainCytoplasmic
TgenePTPRRchr12:104208715chr12:71158558ENST00000342084-01322_2277546Topological domainExtracellular
TgenePTPRRchr12:104208715chr12:71158558ENST00000342084-013249_6577546Topological domainCytoplasmic
TgenePTPRRchr12:104208715chr12:71158558ENST00000378778-01122_2270452Topological domainExtracellular
TgenePTPRRchr12:104208715chr12:71158558ENST00000378778-011249_6570452Topological domainCytoplasmic
TgenePTPRRchr12:104208715chr12:71158558ENST00000440835-01022_227-156413Topological domainExtracellular
TgenePTPRRchr12:104208715chr12:71158558ENST00000440835-010249_657-156413Topological domainCytoplasmic
TgenePTPRRchr12:104208715chr12:71158558ENST00000549308-01122_227-80413Topological domainExtracellular
TgenePTPRRchr12:104208715chr12:71158558ENST00000549308-011249_657-80413Topological domainCytoplasmic
TgenePTPRRchr12:104208715chr12:71158558ENST00000283228-114228_248119658TransmembraneHelical
TgenePTPRRchr12:104208715chr12:71158558ENST00000342084-013228_2487546TransmembraneHelical
TgenePTPRRchr12:104208715chr12:71158558ENST00000378778-011228_2480452TransmembraneHelical
TgenePTPRRchr12:104208715chr12:71158558ENST00000440835-010228_248-156413TransmembraneHelical
TgenePTPRRchr12:104208715chr12:71158558ENST00000549308-011228_248-80413TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNT5DC3chr12:104208715chr12:71158558ENST00000392876-214251_259131549RegionSubstrate binding
TgenePTPRRchr12:104208715chr12:71158558ENST00000283228-11422_227119658Topological domainExtracellular


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FusionGeneSequence for NT5DC3_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_670aa
MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLCTAPGTAPDMKRYLWERYREAKRSTEELVPSIMSNLLNPDAIFSNNE
MSLSDIEITGFDTDYTLVFTSKHLHTLIFNAARDLLINEHRTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVS
PINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFTAVVIFLSIFVIIVTCLMILYRLKERFQLS
LRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMS
SLGNIEPFVSIPTPREKVAMETLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRTKTILPNPLSRVCLRPKN
VTDSLSTYINANTIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGITGKVEVLVISVNECDNY
TIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_2010nt
ATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGGCAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCG
GCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCACCCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGC
TACCGGGAGGCGAAGAGAAGCACAGAAGAATTGGTTCCTTCCATTATGAGCAACTTGTTGAATCCAGATGCCATTTTCTCAAACAATGAA
ATGAGCCTGTCAGACATTGAAATCTATGGCTTCGATTATGATTACACCTTGGTGTTTTATTCAAAGCACCTCCACACGCTGATATTTAAT
GCTGCACGGGACCTTCTCATCAATGAACACCGGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAA
GGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCT
CCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTA
TCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTT
TATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCC
TTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGC
ATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCT
ACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGT
AGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTC
ACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAA
GAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAAT
GTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCC
ATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAAT
GAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTAC
ACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCA
GACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGC
AGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGC
ATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NT5DC3_ENST00000392876_chr12_104208715_-_PTPRR_ENST00000283228_chr12_71158558_-_3153nt
GCAGAGCGGCGCGGCGGCGGTGGCGGCAGCAGGCAGCAGGCATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGG
CAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCGGCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCAC
CCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGCTACCGGGAGGCGAAGAGAAGCACAGAAGAATTGGTTCCTTCCATTATGA
GCAACTTGTTGAATCCAGATGCCATTTTCTCAAACAATGAAATGAGCCTGTCAGACATTGAAATCTATGGCTTCGATTATGATTACACCT
TGGTGTTTTATTCAAAGCACCTCCACACGCTGATATTTAATGCTGCACGGGACCTTCTCATCAATGAACACCGGACACTGCAAATGGATG
TAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATC
GCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAG
TTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAG
GGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTT
TGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCA
CATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACC
CTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAG
AGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGA
AGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAA
GTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTT
TACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCT
ACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACA
GCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAG
TTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGA
AGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACA
GACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCT
GTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTG
AGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAG
ACCATCAATCTCTTGGGGTGATTAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAA
GCCCATGTATGGCATGGATTGTGGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCC
CAAATTATTCTGAAGGTTTTTTGATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTA
TCTGCCACACAGAATGTATGTATGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGT
GTTAGATGCTTTAATGTTTGCAAAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTC
AGTTACCAGAATCTTGCTGCTAAAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAA
ACAGTAACTATTTTATATGGAAATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCA
CAATGATTGTCATTGGGTATATATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCC
ACATCGTGAGTCATTTTACTTTAAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGC
TAAGAAGGGATTTTTGAATATGCTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATT
TTCGAGGCTCCTTATAAGGACATTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACT
ACCCTCAGCAAACACTAGCTGTTCTGCTCATATATGAATTTTTAATGCAGCAATGTTGACTTTGTTTCATACTGCCAATAAACTCTTAAT


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FusionGenePPI for NT5DC3_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NT5DC3ELAVL1, KIF11, EXOSC2, ZNF211, NT5DC2PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NT5DC3_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NT5DC3_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET