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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24986

FusionGeneSummary for NT5DC1_WDR59

check button Fusion gene summary
Fusion gene informationFusion gene name: NT5DC1_WDR59
Fusion gene ID: 24986
HgeneTgene
Gene symbol

NT5DC1

WDR59

Gene ID

221294

79726

Gene name5'-nucleotidase domain containing 1WD repeat domain 59
SynonymsC6orf200|LP2642|NT5C2L1CDW12|FP977|p90-120
Cytomap

6q22.1

16q23.1

Type of geneprotein-codingprotein-coding
Description5'-nucleotidase domain-containing protein 15'-nucleotidase, cytosolic II-like 1 proteinGATOR complex protein WDR59CDw12 antigenWD repeat-containing protein 59
Modification date2018052320180519
UniProtAcc

Q5TFE4

Q6PJI9

Ensembl transtripts involved in fusion geneENST00000319550, ENST00000262144, 
ENST00000562331, 
Fusion gene scores* DoF score9 X 8 X 5=3605 X 5 X 3=75
# samples 95
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NT5DC1 [Title/Abstract] AND WDR59 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF335827NT5DC1chr6

116488917

-WDR59chr16

74991963

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000319550ENST00000262144NT5DC1chr6

116488917

-WDR59chr16

74991963

+
intron-intronENST00000319550ENST00000562331NT5DC1chr6

116488917

-WDR59chr16

74991963

+

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FusionProtFeatures for NT5DC1_WDR59


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NT5DC1

Q5TFE4

WDR59

Q6PJI9

As a component of the GATOR subcomplex GATOR2, functionswithin the amino acid-sensing branch of the TORC1 signalingpathway. Indirectly activates mTORC1 and the TORC1 signalingpathway through the inhibition of the GATOR1 subcomplex(PubMed:23723238). It is negatively regulated by the upstreamamino acid sensors SESN2 and CASTOR1 (PubMed:25457612,PubMed:27487210). {ECO:0000269|PubMed:23723238,ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NT5DC1_WDR59


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NT5DC1_WDR59


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NT5DC1_WDR59


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NT5DC1_WDR59


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNT5DC1C0025202melanoma1CTD_human