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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24973

FusionGeneSummary for NT5C2_DLEU1

check button Fusion gene summary
Fusion gene informationFusion gene name: NT5C2_DLEU1
Fusion gene ID: 24973
HgeneTgene
Gene symbol

NT5C2

DLEU1

Gene ID

22978

10301

Gene name5'-nucleotidase, cytosolic IIdeleted in lymphocytic leukemia 1
SynonymsGMP|NT5B|PNT5|SPG45|SPG65|cN-IIBCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6
Cytomap

10q24.32-q24.33

13q14.2-q14.3

Type of geneprotein-codingncRNA
Descriptioncytosolic purine 5'-nucleotidase5'-nucleotidase (purine), cytosolic type BIMP-specific 5'-NTB-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21
Modification date2018052320180519
UniProtAcc

P49902

O43261

Ensembl transtripts involved in fusion geneENST00000343289, ENST00000404739, 
ENST00000369857, ENST00000423468, 
ENST00000470299, 
ENST00000490577, 
ENST00000378180, 
Fusion gene scores* DoF score6 X 7 X 5=2106 X 5 X 5=150
# samples 106
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NT5C2 [Title/Abstract] AND DLEU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A76Y-01ANT5C2chr10

104899163

-DLEU1chr13

50678840

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343289ENST00000490577NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5CDS-intronENST00000343289ENST00000378180NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5CDS-intronENST00000404739ENST00000490577NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5CDS-intronENST00000404739ENST00000378180NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5UTR-intronENST00000369857ENST00000490577NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5UTR-intronENST00000369857ENST00000378180NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5CDS-intronENST00000423468ENST00000490577NT5C2chr10

104899163

-DLEU1chr13

50678840

+
5CDS-intronENST00000423468ENST00000378180NT5C2chr10

104899163

-DLEU1chr13

50678840

+
intron-intronENST00000470299ENST00000490577NT5C2chr10

104899163

-DLEU1chr13

50678840

+
intron-intronENST00000470299ENST00000378180NT5C2chr10

104899163

-DLEU1chr13

50678840

+

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FusionProtFeatures for NT5C2_DLEU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NT5C2

P49902

DLEU1

O43261

May have a critical role in the maintenance of aconstant composition of intracellular purine/pyrimidinenucleotides in cooperation with other nucleotidases.Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and otherpurine nucleotides. May act as a tumor suppressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NT5C2_DLEU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NT5C2_DLEU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NT5C2NUDT18, NME7, NT5C2, FXR2, MOB3B, NOC4L, CALM1, GNPDA1, HERC4, ADSL, API5, BTF3L4, SZRD1, DRG2, EHD4, RAD23A, USP5, WARS, ASB2, ATP5O, SDCBP, MOB1B, MOB3C, HSPBP1, PTGES3, NTRK1, FBF1, CEP19, DUSP3, SNX15, TRIM25DLEU1ABCD4, ABCF3, GDF9, CCDC90B, PSMA1, SETDB1, SHMT1, TLE1, MED31, COPS6, KAT5, KIAA1377, UTP14A, TP53, TUBB4B, UBR1, EEF1A1, EEF1G, GOPC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NT5C2_DLEU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNT5C2P49902DB00811RibavirinCytosolic purine 5'-nucleotidasesmall moleculeapproved

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RelatedDiseases for NT5C2_DLEU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNT5C2C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human