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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24965

FusionGeneSummary for NSUN2_TBL1Y

check button Fusion gene summary
Fusion gene informationFusion gene name: NSUN2_TBL1Y
Fusion gene ID: 24965
HgeneTgene
Gene symbol

NSUN2

TBL1Y

Gene ID

54888

90665

Gene nameNOP2/Sun RNA methyltransferase family member 2transducin beta like 1 Y-linked
SynonymsMISU|MRT5|SAKI|TRM4TBL1
Cytomap

5p15.31

Yp11.2

Type of geneprotein-codingprotein-coding
DescriptiontRNA (cytosine(34)-C(5))-methyltransferase5-methycytoisine methyltransferaseMyc-induced SUN-domain-containing proteinNOL1/NOP2/Sun domain family, member 2NOP2/Sun domain family, member 2myc-induced SUN domain-containing proteinsubstrate of AIM1/AuroF-box-like/WD repeat-containing protein TBL1Ytransducin beta-like 1transducin beta-like protein 1Ytransducin-beta-like protein 1, Y-linked
Modification date2018052720180523
UniProtAcc

Q08J23

Q9BQ87

Ensembl transtripts involved in fusion geneENST00000264670, ENST00000539938, 
ENST00000506139, ENST00000505264, 
ENST00000355162, ENST00000346432, 
ENST00000383032, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: NSUN2 [Title/Abstract] AND TBL1Y [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSUN2

GO:0030488

tRNA methylation

17071714


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GV-A3JW-01ANSUN2chr5

6632712

-TBL1YchrY

6948773

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000264670ENST00000355162NSUN2chr5

6632712

-TBL1YchrY

6948773

+
Frame-shitENST00000264670ENST00000346432NSUN2chr5

6632712

-TBL1YchrY

6948773

+
Frame-shitENST00000264670ENST00000383032NSUN2chr5

6632712

-TBL1YchrY

6948773

+
5UTR-3CDSENST00000539938ENST00000355162NSUN2chr5

6632712

-TBL1YchrY

6948773

+
5UTR-3CDSENST00000539938ENST00000346432NSUN2chr5

6632712

-TBL1YchrY

6948773

+
5UTR-3CDSENST00000539938ENST00000383032NSUN2chr5

6632712

-TBL1YchrY

6948773

+
Frame-shitENST00000506139ENST00000355162NSUN2chr5

6632712

-TBL1YchrY

6948773

+
Frame-shitENST00000506139ENST00000346432NSUN2chr5

6632712

-TBL1YchrY

6948773

+
Frame-shitENST00000506139ENST00000383032NSUN2chr5

6632712

-TBL1YchrY

6948773

+
intron-3CDSENST00000505264ENST00000355162NSUN2chr5

6632712

-TBL1YchrY

6948773

+
intron-3CDSENST00000505264ENST00000346432NSUN2chr5

6632712

-TBL1YchrY

6948773

+
intron-3CDSENST00000505264ENST00000383032NSUN2chr5

6632712

-TBL1YchrY

6948773

+

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FusionProtFeatures for NSUN2_TBL1Y


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NSUN2

Q08J23

TBL1Y

Q9BQ87

F-box-like protein involved in the recruitment of theubiquitin/19S proteasome complex to nuclear receptor-regulatedtranscription units. Plays an essential role in transcriptionactivation mediated by nuclear receptors. Probably acts asintegral component of corepressor complexes that mediates therecruitment of the 19S proteasome complex, leading to thesubsequent proteasomal degradation of transcription repressorcomplexes, thereby allowing cofactor exchange (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NSUN2_TBL1Y


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NSUN2_TBL1Y


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NSUN2PMS2, NPM1, AURKB, NCL, ARRB2, SIRT7, CUL3, CUL5, CUL1, COPS5, CAND1, FBL, RPS27A, PFDN5, UBA1, AARS, WDR74, VCAM1, ITGA4, FUBP1, HARS, KIAA1279, NRD1, ACTR2, ACTR3, ARPC2, CALR, CALU, EFTUD1, GTF2E1, OSGEP, PANK4, PPP1R12A, PPP2CB, PUS1, SH3GLB1, TP53RK, TSN, TTLL12, XPO5, PFDN1, RANGAP1, RDX, RPA1, SH3GL1, THG1L, UBXN7, UGGT1, CCDC8, EGFR, FGL1, THBS3, CSNK1E, DDX49, GTF2B, PUS7, USP39, PNO1, YES1, NTRK1, LCA5, CEP164, RPL10, SENP3, ZNF746, UBE3A, MPP6, METTL3, ERCC3, NRP1, LIN7C, TUBA4A, LIN7A, CNDP2, PRR20E, SOD1, FOXA1, G3BP1, BRD1TBL1YSUZ12, FOXK2, TBL1X, NCOR2, TBL1XR1, GPS2, NCOR1, HDAC3, CAPN15, INTS6, MAP3K7, LRIF1, CCT2, TAB1, DNAJB1, WDR36, CCT3, CCT7, CCT6A, DNAJB4, CCT4, TCP1, CHD8, FBXL18, CCT5, CCT6B, TUBA4A, TUBB8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NSUN2_TBL1Y


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NSUN2_TBL1Y


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNSUN2C1970199MENTAL RETARDATION, AUTOSOMAL RECESSIVE 51UNIPROT