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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24954

FusionGeneSummary for NSMF_ZMYND19

check button Fusion gene summary
Fusion gene informationFusion gene name: NSMF_ZMYND19
Fusion gene ID: 24954
HgeneTgene
Gene symbol

NSMF

ZMYND19

Gene ID

26012

116225

Gene nameNMDA receptor synaptonuclear signaling and neuronal migration factorzinc finger MYND-type containing 19
SynonymsHH9|NELFMIZIP
Cytomap

9q34.3

9q34.3

Type of geneprotein-codingprotein-coding
DescriptionNMDA receptor synaptonuclear signaling and neuronal migration factornasal embryonic LHRH factornasal embryonic luteinizing hormone-releasing hormone factorzinc finger MYND domain-containing protein 19MCH-R1-interacting zinc finger proteinmelanin-concentrating hormone receptor 1 interacting zinc-finger proteinzinc finger, MYND domain containing 19
Modification date2018051920180522
UniProtAcc

Q6X4W1

Q96E35

Ensembl transtripts involved in fusion geneENST00000339554, ENST00000371475, 
ENST00000371473, ENST00000437259, 
ENST00000392812, ENST00000265663, 
ENST00000371474, ENST00000371482, 
ENST00000371472, ENST00000541195, 
ENST00000484316, ENST00000371468, 
ENST00000298585, ENST00000471957, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 3 X 7=105
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NSMF [Title/Abstract] AND ZMYND19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A4OS-01ANSMFchr9

140346817

-ZMYND19chr9

140477138

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000339554ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000339554ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000371475ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000371475ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000371473ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000371473ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000437259ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000437259ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000392812ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000392812ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000265663ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000265663ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000371474ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000371474ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
In-frameENST00000371482ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000371482ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000371472ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000371472ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
Frame-shiftENST00000541195ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5CDS-intronENST00000541195ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5UTR-3CDSENST00000484316ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
5UTR-intronENST00000484316ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-
intron-3CDSENST00000371468ENST00000298585NSMFchr9

140346817

-ZMYND19chr9

140477138

-
intron-intronENST00000371468ENST00000471957NSMFchr9

140346817

-ZMYND19chr9

140477138

-

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FusionProtFeatures for NSMF_ZMYND19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NSMF

Q6X4W1

ZMYND19

Q96E35

May be involved as a regulatory molecule in GPR24/MCH-R1signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NSMF_ZMYND19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NSMF_ENST00000371482_chr9_140346817_-_ZMYND19_ENST00000298585_chr9_140477138_-_124aa
MGLGPLSSSLSPQLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQLREFNICGRCQVAR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NSMF_ENST00000371482_chr9_140346817_-_ZMYND19_ENST00000298585_chr9_140477138_-_372nt
ATGGGCCTGGGGCCCCTGAGCAGCTCTTTGTCTCCGCAGCTCATTTCCTCCAAGGTGCCCAAGGCTGAGTACATCCCCACTATCATCCGC
CGGGATGACCCCTCCATCATCCCCATCCTCTACGACCATGAGCACGCAACCTTCGAGGACATCCTTGAGGAGATAGAGAGGAAGCTGAAC
GTCTACCACAAGGGAGCCAAGATCTGGAAAATGCTGATTTTCTGCCAGCTCCGGGAGTTCAACATCTGTGGGCGCTGCCAGGTGGCCCGG
TACTGCGGCTCCCAGTGCCAGCAGAAGGACTGGCCTGCCCACAAGAAGCACTGTCGGGAGAGGAAGCGTCCCTTCCAGCATGAGCTTGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NSMF_ENST00000371482_chr9_140346817_-_ZMYND19_ENST00000298585_chr9_140477138_-_1970nt
TCTGGAGTTGAAGGGGAGCCCTGGAAGGCTGTCGCGGGAAGAGCACTGGGTGGGATTTGCCTTTGGGTGGGAGGTGGTGCCAGGAGCCAG
GGAGAGCACTGGCTTCCCACACCGAAGGGGAACTTCCGCAAACACCTGCGCATGGTCGGCAGCCGGAGGGTGAAGGCCCAGACGTTCGCT
GAGCGGCGCGAGCGGAGCTTCAGCCGGTCCTGGAGCGACCCCACCCCCATGAAAGCCGACACTTCCCACGACTCCCGAGACAGTAGGTGC
CCCGCACAGGCCCGCCCACCTTCCCCAGAGCCTCCCCTAGACCCCAGACCCCTGCTGGGGGTCCCCTGCCAGGGCCGCTGGGCTGCGCTT
TTGCACTCCTGAATCTTGGTTTACCTGTTTGTGAGATGGGGACGCCCTCAGCATCTCCGATCGCAAAGGCGGGGCTAACAACGGCCGCGG
CAGTGCTGGCCGGGGGCGCCTGTAGGGCCGTGCCCACCGCCACTCGCAAGAGGCCCTCAGGGGCAGGGGGCTGCGGTGCCCGCCCCCACT
CCCTCCCAGGCGCCCGGCGGACTTGGCTGGAGCTGATGCCTGCACGCGCCTTCCACCGGCCTCGCACCAGGGTCTCCCTTCCCACATCAG
GCCGCTGCCCAGTGGTGTCCACAGGCCTGTCCTGCCGGGCTGGCGGCGACCTCTGTATGGTCCTCCCACTTGCTTGGAGGACCCTCCGGG
ATGGGGCTTTCGGGCCCTGTGGGCCTTGGGGCCATGGCCAGGATAGGAGGTGCTGCCGGGCCTGCTGTCCTGGTGACCCTCTTGCTTCCC
AGGCAGTGACCTGCAGAGCTCCCACTGCACGCTGGACGAGGCCTTCGAGGACCTGGACTGGGACACTGAGAAGGGCCTGGAGGCTGTGGC
CTGCGACACCGAAGGCTTCGTGCCACCAAAGGTCATGGTGAGGCCCAGCCCGGGCAGTGCTCCTCTACACCCCGAGCAGGACTCCGCCCC
AACCCGAGTCCAGCCAGCTCTGCCTGGGACCACGCAGCCTTCTCCAGCTGCCTGGGGGAGGGTGTCTCACAGGGCTATACCCTTGGGCTG
CCTGGCAGCCAGAAGGTAGCCTCATGGGGGCTCCCACAGCCCCTTGGCTTTTGGATGGGCCTGGGGCCCCTGAGCAGCTCTTTGTCTCCG
CAGCTCATTTCCTCCAAGGTGCCCAAGGCTGAGTACATCCCCACTATCATCCGCCGGGATGACCCCTCCATCATCCCCATCCTCTACGAC
CATGAGCACGCAACCTTCGAGGACATCCTTGAGGAGATAGAGAGGAAGCTGAACGTCTACCACAAGGGAGCCAAGATCTGGAAAATGCTG
ATTTTCTGCCAGCTCCGGGAGTTCAACATCTGTGGGCGCTGCCAGGTGGCCCGGTACTGCGGCTCCCAGTGCCAGCAGAAGGACTGGCCT
GCCCACAAGAAGCACTGTCGGGAGAGGAAGCGTCCCTTCCAGCATGAGCTTGAGCCAGAGCGATGACGGGCAGGGGAGCCACACATACTC
ACAGCCCCCGGGCTCTACCCTGGGCACAGCAGAGACAGACTGGTGGTTGAACCTGGAGGTGCCAAAAAAGCCAGCTGCGGGCCCAGGACA
GCTGCCGTGAGACTCCCGATGTCACAGGCAGTCTGTGTGGTTACAGCGCCCCTCAGTGTTCATCTCCAGCAGAGACAACGGAGGAGGCTC
CCACCAGGACGGTTCTCATTATTTATATGTTAATATGTTTGTAAACTCATGTACAGTTTTTTTTGGGGGGGAGGCAATGGGAAGGGTAGA
AATTACAAATAGAATCATTTGCTGTAATCCTTAAATGGCAAACGGTCAGGCCACGTGACTAAAAACTGTCCTGTTGTCGAAGCTTCTCCC


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FusionGenePPI for NSMF_ZMYND19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NSMFHSPB3, GFI1B, SUPT5H, POLR2A, KCTD15, RBPJ, RNF123, NDUFAF5ZMYND19PPP1R37, HACL1, KCTD13, TNNT1, ELAVL1, NAB2, TRIM27, TOX4, ENOX1, FIP1L1, LZTS2, PNMA5, FAM154A, SELV, INCA1, CCDC183, GLIPR1L2, TDGF1, MRPL4, RMND5A, MRPS30, PRG2, TNFAIP1, PRG3, TIGD5, PIGT, GABRA6, INSL6, NEU4, KRBA1, CDK5RAP1, SUCLA2, CCDC120, IKZF1, TLE4, NFATC1, BMP1, TMEM70, NDUFS6, MKLN1, ARMC8, RANBP9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NSMF_ZMYND19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NSMF_ZMYND19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNSMFC3553842HYPOGONADOTROPIC HYPOGONADISM 9 WITH OR WITHOUT ANOSMIA2UNIPROT
HgeneNSMFC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNSMFC0024667Animal Mammary Neoplasms1CTD_human
HgeneNSMFC0024668Mammary Neoplasms, Experimental1CTD_human