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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2490

FusionGeneSummary for ARHGDIA_TNNT3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGDIA_TNNT3
Fusion gene ID: 2490
HgeneTgene
Gene symbol

ARHGDIA

TNNT3

Gene ID

396

7140

Gene nameRho GDP dissociation inhibitor alphatroponin T3, fast skeletal type
SynonymsGDIA1|HEL-S-47e|NPHS8|RHOGDI|RHOGDI-1TNTF|beta-TnTF
Cytomap

17q25.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionrho GDP-dissociation inhibitor 1GDP-dissociation inhibitor, aplysia RAS-related 1Rho GDP dissociation inhibitor (GDI) alphaepididymis secretory sperm binding protein Li 47etroponin T, fast skeletal muscletroponin T type 3 (skeletal, fast)
Modification date2018052320180524
UniProtAcc

P52565

P45378

Ensembl transtripts involved in fusion geneENST00000582520, ENST00000269321, 
ENST00000400721, ENST00000584461, 
ENST00000541078, ENST00000580685, 
ENST00000581876, 		ENST00000278317, 
ENST00000360603, ENST00000381561, 
ENST00000381549, ENST00000381548, 
ENST00000381579, ENST00000381589, 
ENST00000381558, ENST00000397301, 
ENST00000446240, ENST00000397304, 
ENST00000493234, 
Fusion gene scores* DoF score5 X 2 X 5=501 X 1 X 1=1
# samples 61
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: ARHGDIA [Title/Abstract] AND TNNT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNNT3

GO:0003009

skeletal muscle contraction

17194691

TgeneTNNT3

GO:0006942

regulation of striated muscle contraction

17194691

TgeneTNNT3

GO:0043462

regulation of ATPase activity

17194691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA722860ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000582520ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000582520ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000582520ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000582520ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000582520ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000582520ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000269321ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000269321ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000269321ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000269321ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000269321ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000400721ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000400721ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000400721ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000400721ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000400721ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000584461ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000584461ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000584461ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000584461ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000584461ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000541078ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000541078ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000541078ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000541078ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000541078ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000580685ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000580685ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000580685ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000580685ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000580685ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000278317ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000360603ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381561ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381549ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381548ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381579ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381589ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-3UTRENST00000581876ENST00000381558ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000581876ENST00000397301ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000581876ENST00000446240ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000581876ENST00000397304ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-
intron-intronENST00000581876ENST00000493234ARHGDIAchr17

79825654

+TNNT3chr11

1959751

-

Top

FusionProtFeatures for ARHGDIA_TNNT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGDIA

P52565

TNNT3

P45378

Controls Rho proteins homeostasis. Regulates the GDP/GTPexchange reaction of the Rho proteins by inhibiting thedissociation of GDP from them, and the subsequent binding of GTPto them. Retains Rho proteins such as CDC42, RAC1 and RHOA in aninactive cytosolic pool, regulating their stability and protectingthem from degradation. Actively involved in the recycling anddistribution of activated Rho GTPases in the cell, mediatesextraction from membranes of both inactive and activated moleculesdue its exceptionally high affinity for prenylated forms. Throughthe modulation of Rho proteins, may play a role in cell motilityregulation. In glioma cells, inhibits cell migration and invasionby mediating the signals of SEMA5A and PLXNB3 that lead toinactivation of RAC1. {ECO:0000269|PubMed:20400958,ECO:0000269|PubMed:23434736}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGDIA_TNNT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGDIA_TNNT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGDIARHOA, RAC1, RHOC, CDC42, EIF2B1, DHX9, IGF2BP1, HNRNPAB, EWSR1, HNRNPA3, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, MSN, CASP10, CASP8, FAS, TNFRSF1A, ACTL6A, CDKN1B, NEDD4L, SH3GL3, JUP, FEN1, RDX, RHOH, ARHGDIA, RAC2, RHOG, RAC3, BAK1, UBE2R2, CBX5, SDHC, MAPK6, TRIM13, UBE2L6, UFM1, HERPUD1, HAAO, TWF2, XIAP, ESR1, SIRT7, TERF1, TINF2, POT1, CUL3, CDK2, PSMD10, ATXN3, PIR, CASP3, CASP7, ADRB2, IKBKG, CUL7, CCDC8, ALDOA, AHNAK, ALDOC, ASS1, COMMD4, COTL1, DUT, ENO2, HSD17B10, HSPB1, IMPA1, IMPA2, ISYNA1, PCNA, PLS3, RAB11A, RAP1A, TXN, UCHL3, FAM98B, GDI1, HINT1, NPEPL1, PDIA3, PFKM, PFKP, SUMO3, SUMO4, NTRK1, U2AF2, STOM, ANKRD13A, PRRC2B, EIF2B4, FBXW7, UBE2I, EP300, KAT2B, SIRT2, HDAC6TNNT3SNUPN, HAP1, TRIM63, TSG101, NUDT3, TNNT3, PGPEP1, NLGN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARHGDIA_TNNT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGDIA_TNNT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGDIAC0019693HIV Infections1CTD_human
HgeneARHGDIAC0022548Keloid1CTD_human
HgeneARHGDIAC0027627Neoplasm Metastasis1CTD_human
HgeneARHGDIAC1458155Mammary Neoplasms1CTD_human
TgeneTNNT3C1834523ARTHROGRYPOSIS, DISTAL, TYPE 2B1CTD_human;ORPHANET;UNIPROT