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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24890

FusionGeneSummary for NRXN3_TSHR

check button Fusion gene summary
Fusion gene informationFusion gene name: NRXN3_TSHR
Fusion gene ID: 24890
HgeneTgene
Gene symbol

NRXN3

TSHR

Gene ID

9369

7253

Gene nameneurexin 3thyroid stimulating hormone receptor
SynonymsC14orf60CHNG1|LGR3|hTSHR-I
Cytomap

14q24.3-q31.1

14q31.1

Type of geneprotein-codingprotein-coding
Descriptionneurexin 3neurexin IIIneurexin-3-alphathyrotropin receptorTSH receptorseven transmembrane helix receptorthyrotropin receptor-I, hTSHR-I
Modification date2018051920180523
UniProtAcc

Q9Y4C0

P16473

Ensembl transtripts involved in fusion geneENST00000554719, ENST00000335750, 
ENST00000557594, ENST00000281127, 
ENST00000428277, ENST00000556003, 
ENST00000541158, ENST00000342443, 
ENST00000298171, ENST00000554263, 
ENST00000554435, ENST00000557096, 
Fusion gene scores* DoF score5 X 6 X 3=905 X 3 X 5=75
# samples 65
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRXN3 [Title/Abstract] AND TSHR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-S9-A89Z-01ANRXN3chr14

79454484

+TSHRchr14

81528492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000554719ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000554719ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000554719ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000554719ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000554719ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
5CDS-intronENST00000554719ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000335750ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000335750ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000335750ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000335750ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
Frame-shiftENST00000335750ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
5CDS-intronENST00000335750ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000557594ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000557594ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000557594ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000557594ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000557594ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-intronENST00000557594ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000281127ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000281127ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000281127ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000281127ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000281127ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-intronENST00000281127ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000428277ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000428277ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000428277ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000428277ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000428277ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-intronENST00000428277ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000556003ENST00000541158NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000556003ENST00000342443NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000556003ENST00000298171NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000556003ENST00000554263NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-3CDSENST00000556003ENST00000554435NRXN3chr14

79454484

+TSHRchr14

81528492

+
intron-intronENST00000556003ENST00000557096NRXN3chr14

79454484

+TSHRchr14

81528492

+

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FusionProtFeatures for NRXN3_TSHR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRXN3

Q9Y4C0

TSHR

P16473


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRXN3_TSHR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRXN3_TSHR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRXN3NLGN1, NLGN2, NLGN3, MLLT4, MYC, GPR183, PIP5K1A, FAM19A4, CAMKV, CBLN4, FAM19A1TSHRFLNB, CANX, HSPA5, JAK2, JAK1, STAT3, FN1, SCRIB, ADRB2, IQGAP2, SALL2, CAMK2D, POTEF, PC, PTK7, TUBA1A, CBWD1, MOCOS, ITPA, STIL, SAMD1, LAMA3, BORA, FBXO7, TRMT44, GOLGA2, CALR, MLF1, TUBA4A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NRXN3_TSHR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTSHRP16473DB00024Thyrotropin AlfaThyrotropin receptorbiotechapproved|vet_approved

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RelatedDiseases for NRXN3_TSHR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRXN3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNRXN3C0036341Schizophrenia1PSYGENET
HgeneNRXN3C0236969Substance-Related Disorders1CTD_human
HgeneNRXN3C0853193Bipolar I disorder1PSYGENET
TgeneTSHRC1836706Hyperthyroidism, Nonautoimmune22CTD_human;ORPHANET;UNIPROT
TgeneTSHRC3493776HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 112ORPHANET;UNIPROT
TgeneTSHRC0020550Hyperthyroidism3CTD_human;HPO
TgeneTSHRC0018213Graves Disease2CTD_human
TgeneTSHRC0040136Thyroid Neoplasm2CTD_human
TgeneTSHRC0001430Adenoma1CTD_human
TgeneTSHRC0001624Adrenal Gland Neoplasms1CTD_human
TgeneTSHRC0010308Congenital Hypothyroidism1CTD_human;HPO
TgeneTSHRC0024121Lung Neoplasms1CTD_human
TgeneTSHRC0024232Lymphatic Metastasis1CTD_human
TgeneTSHRC0040156Thyrotoxicosis1CTD_human
TgeneTSHRC0920350Autoimmune thyroiditis1CTD_human
TgeneTSHRC1863959Hyperthyroidism, Familial Gestational1CTD_human;ORPHANET;UNIPROT