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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24887

FusionGeneSummary for NRXN3_FMNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRXN3_FMNL1
Fusion gene ID: 24887
HgeneTgene
Gene symbol

NRXN3

FMNL1

Gene ID

9369

752

Gene nameneurexin 3formin like 1
SynonymsC14orf60C17orf1|C17orf1B|FHOD4|FMNL|KW-13
Cytomap

14q24.3-q31.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionneurexin 3neurexin IIIneurexin-3-alphaformin-like protein 1CLL-associated antigen KW-13leukocyte formin
Modification date2018051920180519
UniProtAcc

Q9Y4C0

O95466

Ensembl transtripts involved in fusion geneENST00000554719, ENST00000335750, 
ENST00000557594, ENST00000281127, 
ENST00000428277, ENST00000556003, 
ENST00000331495, ENST00000328118, 
ENST00000592006, ENST00000587489, 
Fusion gene scores* DoF score5 X 6 X 3=904 X 4 X 3=48
# samples 64
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRXN3 [Title/Abstract] AND FMNL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA961679NRXN3chr14

80287292

-FMNL1chr17

43321086

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000554719ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000554719ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000554719ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000554719ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000335750ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000335750ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000335750ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000335750ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000557594ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000557594ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000557594ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000557594ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000281127ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000281127ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000281127ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000281127ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000428277ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000428277ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000428277ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000428277ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000556003ENST00000331495NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000556003ENST00000328118NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000556003ENST00000592006NRXN3chr14

80287292

-FMNL1chr17

43321086

-
intron-intronENST00000556003ENST00000587489NRXN3chr14

80287292

-FMNL1chr17

43321086

-

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FusionProtFeatures for NRXN3_FMNL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRXN3

Q9Y4C0

FMNL1

O95466

May play a role in the control of cell motility andsurvival of macrophages (By similarity). Plays a role in theregulation of cell morphology and cytoskeletal organization.Required in the cortical actin filament dynamics and cell shape.{ECO:0000250, ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRXN3_FMNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRXN3_FMNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRXN3_FMNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRXN3_FMNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRXN3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNRXN3C0036341Schizophrenia1PSYGENET
HgeneNRXN3C0236969Substance-Related Disorders1CTD_human
HgeneNRXN3C0853193Bipolar I disorder1PSYGENET
TgeneFMNL1C0023893Liver Cirrhosis, Experimental1CTD_human