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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24877

FusionGeneSummary for NRROS_CST7

check button Fusion gene summary
Fusion gene informationFusion gene name: NRROS_CST7
Fusion gene ID: 24877
HgeneTgene
Gene symbol

NRROS

CST7

Gene ID

375387

8530

Gene namenegative regulator of reactive oxygen speciescystatin F
SynonymsELLP3030|GARPL1|LRRC33|UNQ3030CMAP
Cytomap

3q29

20p11.21

Type of geneprotein-codingprotein-coding
Descriptionnegative regulator of reactive oxygen speciesleucine-rich repeat-containing protein 33cystatin-Fcystatin-7cystatin-like metastasis-associated proteinleukocystatin
Modification date2018052320180519
UniProtAcc

Q86YC3

O76096

Ensembl transtripts involved in fusion geneENST00000328557, ENST00000376835, 
ENST00000480798, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: NRROS [Title/Abstract] AND CST7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM564264NRROSchr3

196383703

-CST7chr20

24929924

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000328557ENST00000376835NRROSchr3

196383703

-CST7chr20

24929924

+
intron-5UTRENST00000328557ENST00000480798NRROSchr3

196383703

-CST7chr20

24929924

+

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FusionProtFeatures for NRROS_CST7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRROS

Q86YC3

CST7

O76096

Negative regulator of reactive oxygen species (ROS) thatlimits ROS production by phagocytes during inflammatory response,thereby playing a role during host defense. Acts via directinteraction with CYBB/NOX2 monomer that impairs interactionbetween CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2complex (By similarity). May play a critical role in desensitizingTLR signaling through inhibition of Toll-like receptor-mediatedNF-kappa-B activation and cytokine production. {ECO:0000250,ECO:0000269|PubMed:23545260}. Inhibits papain and cathepsin L but with affinitieslower than other cystatins. May play a role in immune regulationthrough inhibition of a unique target in the hematopoietic system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRROS_CST7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRROS_CST7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRROS_CST7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRROS_CST7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRROSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCST7C0038356Stomach Neoplasms1CTD_human