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Fusion gene ID: 24854 |
FusionGeneSummary for NRG4_SCNN1D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRG4_SCNN1D | Fusion gene ID: 24854 | Hgene | Tgene | Gene symbol | NRG4 | SCNN1D | Gene ID | 145957 | 6339 |
| Gene name | neuregulin 4 | sodium channel epithelial 1 delta subunit | |
| Synonyms | HRG4 | ENaCd|ENaCdelta|SCNED|dNaCh | |
| Cytomap | 15q24.2 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pro-neuregulin-4, membrane-bound isoformheregulin 4pro-NRG4 | amiloride-sensitive sodium channel subunit deltadelta-ENaCdelta-NaCHepithelial Na(+) channel subunit deltanonvoltage-gated sodium channel 1 subunit deltasodium channel, non-voltage-gated 1, delta subunitsodium channel, nonvoltage-gated 1, deltasodi | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8WWG1 | P51172 | |
| Ensembl transtripts involved in fusion gene | ENST00000394907, ENST00000535975, ENST00000305435, ENST00000563582, | ENST00000379116, ENST00000338555, ENST00000325425, ENST00000467651, ENST00000400928, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NRG4 [Title/Abstract] AND SCNN1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5J1-01A | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000394907 | ENST00000379116 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| Frame-shift | ENST00000394907 | ENST00000338555 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| Frame-shift | ENST00000394907 | ENST00000325425 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000394907 | ENST00000467651 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000394907 | ENST00000400928 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| Frame-shift | ENST00000535975 | ENST00000379116 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| Frame-shift | ENST00000535975 | ENST00000338555 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| Frame-shift | ENST00000535975 | ENST00000325425 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000535975 | ENST00000467651 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000535975 | ENST00000400928 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| In-frame | ENST00000305435 | ENST00000379116 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| In-frame | ENST00000305435 | ENST00000338555 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| In-frame | ENST00000305435 | ENST00000325425 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000305435 | ENST00000467651 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| 5CDS-intron | ENST00000305435 | ENST00000400928 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| intron-3CDS | ENST00000563582 | ENST00000379116 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| intron-3CDS | ENST00000563582 | ENST00000338555 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| intron-3CDS | ENST00000563582 | ENST00000325425 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| intron-intron | ENST00000563582 | ENST00000467651 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
| intron-intron | ENST00000563582 | ENST00000400928 | NRG4 | chr15 | 76301541 | - | SCNN1D | chr1 | 1225857 | + |
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FusionProtFeatures for NRG4_SCNN1D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NRG4 | SCNN1D |
| Low affinity ligand for the ERBB4 tyrosine kinasereceptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors,resulting in ligand-stimulated tyrosine phosphorylation andactivation of the ERBB receptors. Does not bind to the ERBB1,ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}. | Sodium permeable non-voltage-sensitive ion channelinhibited by the diuretic amiloride. Mediates the electrodiffusionof the luminal sodium (and water, which follows osmotically)through the apical membrane of epithelial cells. Controls thereabsorption of sodium in kidney, colon, lung and sweat glands.Also plays a role in taste perception.{ECO:0000269|PubMed:16423824, ECO:0000269|PubMed:7499195}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NRG4_SCNN1D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000379116_chr1_1225857_+_209aa DTASTASTRTWRPTGSPVPPAAPGPAGSLHSSSPLGPPGGLPPSQLDGLWPRXVNRGCRIRATDRGAAWPKSTSSTRSSTTAQWRRRPCT RCRSCSRPWAASAACGLGPPSSPSWSSWSCCSMLLPSPWCXAAAGSAGRGSPGPEPALPQGRPASSQRPVRCPRLQAARQMTRSPAGLIS >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000338555_chr1_1225857_+_209aa DTASTASTRTWRPTGSPVPPAAPGPAGSLHSSSPLGPPGGLPPSQLDGLWPRXVNRGCRIRATDRGAAWPKSTSSTRSSTTAQWRRRPCT RCRSCSRPWAASAACGLGPPSSPSWSSWSCCSMLLPSPWCXAAAGSAGRGSPGPEPALPQGRPASSQRPVRCPRLQAARQMTRSPAGLIS >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000325425_chr1_1225857_+_209aa DTASTASTRTWRPTGSPVPPAAPGPAGSLHSSSPLGPPGGLPPSQLDGLWPRXVNRGCRIRATDRGAAWPKSTSSTRSSTTAQWRRRPCT RCRSCSRPWAASAACGLGPPSSPSWSSWSCCSMLLPSPWCXAAAGSAGRGSPGPEPALPQGRPASSQRPVRCPRLQAARQMTRSPAGLIS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000379116_chr1_1225857_+_629nt GACACTGCTTCTACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCAT TCAAGCTCTCCACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATC AGAGCCACAGACAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACT CGGTGCCGCAGCTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGC TGCTCGATGCTTCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAG GGGCGTCCAGCATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCC >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000338555_chr1_1225857_+_629nt GACACTGCTTCTACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCAT TCAAGCTCTCCACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATC AGAGCCACAGACAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACT CGGTGCCGCAGCTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGC TGCTCGATGCTTCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAG GGGCGTCCAGCATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCC >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000325425_chr1_1225857_+_629nt GACACTGCTTCTACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCAT TCAAGCTCTCCACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATC AGAGCCACAGACAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACT CGGTGCCGCAGCTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGC TGCTCGATGCTTCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAG GGGCGTCCAGCATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000379116_chr1_1225857_+_1477nt GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000338555_chr1_1225857_+_1482nt GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC >In-frame_NRG4_ENST00000305435_chr15_76301541_-_SCNN1D_ENST00000325425_chr1_1225857_+_1482nt GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC |
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FusionGenePPI for NRG4_SCNN1D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NRG4 | FATE1, CREB3 | SCNN1D | COMMD1, CUL1, SKP1, STX11, ABHD16A, MTFR2, TAP2, DPY19L1, CLSTN3, AMIGO1, CFAP74, LRRC3, CLPTM1, ANGEL1, ALG9, ERMP1, LRP12, POMT1, CANX, DNAJC16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRG4_SCNN1D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SCNN1D | P51172 | DB00384 | Triamterene | Amiloride-sensitive sodium channel subunit delta | small molecule | approved |
| Tgene | SCNN1D | P51172 | DB00594 | Amiloride | Amiloride-sensitive sodium channel subunit delta | small molecule | approved |
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RelatedDiseases for NRG4_SCNN1D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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