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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24844

FusionGeneSummary for NRG1_KRT78

check button Fusion gene summary
Fusion gene informationFusion gene name: NRG1_KRT78
Fusion gene ID: 24844
HgeneTgene
Gene symbol

NRG1

KRT78

Gene ID

3084

196374

Gene nameneuregulin 1keratin 78
SynonymsARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDFCK-78|K5B|K78|Kb40
Cytomap

8p12

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factorkeratin, type II cytoskeletal 78cytokeratin-78keratin 78, type IIkeratin-5btype-II keratin Kb40
Modification date2018052320180519
UniProtAcc

Q02297

Q8N1N4

Ensembl transtripts involved in fusion geneENST00000519301, ENST00000520407, 
ENST00000523079, ENST00000338921, 
ENST00000356819, ENST00000287845, 
ENST00000341377, ENST00000287842, 
ENST00000521670, ENST00000405005, 
ENST00000520502, ENST00000539990, 
ENST00000523681, 
ENST00000359499, 
ENST00000304620, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 2 X 4=40
# samples 65
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRG1 [Title/Abstract] AND KRT78 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

HgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

HgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

HgeneNRG1

GO:0043497

regulation of protein heterodimerization activity

10559227

HgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

HgeneNRG1

GO:0051048

negative regulation of secretion

10559227

HgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

HgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-CF-A3MI-01ANRG1chr8

32406344

+KRT78chr12

53233768

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000519301ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000519301ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000520407ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000520407ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000523079ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000523079ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000338921ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000338921ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000356819ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000356819ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000287845ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000287845ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000341377ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000341377ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000287842ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000287842ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000521670ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000521670ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000405005ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
Frame-shiftENST00000405005ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000520502ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000520502ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000539990ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000539990ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000523681ENST00000359499NRG1chr8

32406344

+KRT78chr12

53233768

-
intron-3CDSENST00000523681ENST00000304620NRG1chr8

32406344

+KRT78chr12

53233768

-

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FusionProtFeatures for NRG1_KRT78


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRG1

Q02297

KRT78

Q8N1N4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRG1_KRT78


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRG1_KRT78


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRG1LIMK1, ERBB3, ERBB2, EGFR, ERBB4, MBOAT7, LSR, PGAP1, KIAA2013, SREBF2, LEMD3, TMTC3, TMTC4, POMGNT2, SLC38A10, ATP7B, SLC35B2, NDUFA3, ZDHHC17, TMEM39B, DNAAF5, B3GNT2, RHOBTB3, CISD2, POMT1, SPTLC2, SLC25A16, RDH11, MGAT1, HMOX1, KIAA1467, EXTL3, SLC25A23, NETO2, LPHN1, CNTNAP3, HLA-DPB1, UQCRQ, GLMN, DEGS1, TMEM63B, DDX11L8, ABCB10, GYLTL1B, B3GALNT2, TMEM181, INTS7, MYO19, GALNT11, C1GALT1C1, SLC22A18, NEK4, ABCA3, TMEM164, MTCH1, OPA3, HS6ST1, SFXN3, TM2D3, DSE, TMEM205, RNF130, PIGU, CDC5L, LGR4, TUBB3KRT78SIRT2, UCHL5, CUL3, CUL2, COPS5, CRK, IQCB1, CCDC8, HNRNPA1, SRPK2, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRG1_KRT78


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRG1_KRT78


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRG1C0036341Schizophrenia7CTD_human
HgeneNRG1C0005586Bipolar Disorder5PSYGENET
HgeneNRG1C0024809Marijuana Abuse3PSYGENET
HgeneNRG1C0011570Mental Depression2PSYGENET
HgeneNRG1C0011581Depressive disorder2PSYGENET
HgeneNRG1C0006870Cannabis Dependence1PSYGENET
HgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNRG1C0011616Contact Dermatitis1CTD_human
HgeneNRG1C0018801Heart failure1CTD_human
HgeneNRG1C0019569Hirschsprung Disease1CTD_human
HgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNRG1C0026650Movement Disorders1CTD_human
HgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
HgeneNRG1C0030193Pain1CTD_human
HgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneNRG1C0033937Psychoses, Drug1PSYGENET
HgeneNRG1C0038358Gastric ulcer1CTD_human
HgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
HgeneNRG1C1458155Mammary Neoplasms1CTD_human
HgeneNRG1C3495559Juvenile arthritis1CTD_human