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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24830

FusionGeneSummary for NRCAM_NRCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: NRCAM_NRCAM
Fusion gene ID: 24830
HgeneTgene
Gene symbol

NRCAM

NRCAM

Gene ID

4897

4897

Gene nameneuronal cell adhesion moleculeneuronal cell adhesion molecule
Synonyms--
Cytomap

7q31.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravoneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo
Modification date2018051920180519
UniProtAcc

Q92823

Q92823

Ensembl transtripts involved in fusion geneENST00000379028, ENST00000413765, 
ENST00000351718, ENST00000379024, 
ENST00000379022, ENST00000425651, 
ENST00000522550, 
ENST00000379028, 
ENST00000413765, ENST00000351718, 
ENST00000379024, ENST00000379022, 
ENST00000425651, ENST00000522550, 
Fusion gene scores* DoF score7 X 6 X 5=2103 X 3 X 3=27
# samples 94
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRCAM [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817

TgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF593690NRCAMchr7

107788350

+NRCAMchr7

107789159

-
ChiTaRS3.1AI401223NRCAMchr7

107788350

+NRCAMchr7

107789159

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000379028ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379028ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379028ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379028ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000413765ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000413765ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000413765ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000351718ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000351718ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000351718ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379024ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379024ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379024ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379022ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379022ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379022ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000425651ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000425651ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000425651ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000522550ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000522550ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000522550ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-

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FusionProtFeatures for NRCAM_NRCAM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRCAM

Q92823

NRCAM

Q92823

Cell adhesion protein that is required for normalresponses to cell-cell contacts in brain and in the peripheralnervous system. Plays a role in neurite outgrowth in response tocontactin binding. Plays a role in mediating cell-cell contactsbetween Schwann cells and axons. Plays a role in the formation andmaintenance of the nodes of Ranvier on myelinated axons. Nodes ofRanvier contain clustered sodium channels that are crucial for thesaltatory propagation of action potentials along myelinated axons.During development, nodes of Ranvier are formed by the fusion oftwo heminodes. Required for normal clustering of sodium channelsat heminodes; not required for the formation of mature nodes withnormal sodium channel clusters. Required, together with GLDN, formaintaining NFASC and sodium channel clusters at mature nodes ofRanvier. {ECO:0000250|UniProtKB:Q810U4}. Cell adhesion protein that is required for normalresponses to cell-cell contacts in brain and in the peripheralnervous system. Plays a role in neurite outgrowth in response tocontactin binding. Plays a role in mediating cell-cell contactsbetween Schwann cells and axons. Plays a role in the formation andmaintenance of the nodes of Ranvier on myelinated axons. Nodes ofRanvier contain clustered sodium channels that are crucial for thesaltatory propagation of action potentials along myelinated axons.During development, nodes of Ranvier are formed by the fusion oftwo heminodes. Required for normal clustering of sodium channelsat heminodes; not required for the formation of mature nodes withnormal sodium channel clusters. Required, together with GLDN, formaintaining NFASC and sodium channel clusters at mature nodes ofRanvier. {ECO:0000250|UniProtKB:Q810U4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRCAM_NRCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRCAM_NRCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRCAM_NRCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRCAM_NRCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRCAMC0004352Autistic Disorder2CTD_human
HgeneNRCAMC0009404Colorectal Neoplasms2CTD_human
HgeneNRCAMC0236969Substance-Related Disorders1CTD_human
HgeneNRCAMC1458155Mammary Neoplasms1CTD_human
TgeneNRCAMC0004352Autistic Disorder2CTD_human
TgeneNRCAMC0009404Colorectal Neoplasms2CTD_human
TgeneNRCAMC0236969Substance-Related Disorders1CTD_human
TgeneNRCAMC1458155Mammary Neoplasms1CTD_human