FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24827

FusionGeneSummary for NRCAM_BNC2

check button Fusion gene summary
Fusion gene informationFusion gene name: NRCAM_BNC2
Fusion gene ID: 24827
HgeneTgene
Gene symbol

NRCAM

BNC2

Gene ID

4897

54796

Gene nameneuronal cell adhesion moleculebasonuclin 2
Synonyms-BSN2
Cytomap

7q31.1

9p22.3-p22.2

Type of geneprotein-codingprotein-coding
Descriptionneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravozinc finger protein basonuclin-2
Modification date2018051920180519
UniProtAcc

Q92823

Q6ZN30

Ensembl transtripts involved in fusion geneENST00000379028, ENST00000413765, 
ENST00000351718, ENST00000379024, 
ENST00000379022, ENST00000425651, 
ENST00000522550, 
ENST00000380672, 
ENST00000380667, ENST00000545497, 
ENST00000380666, ENST00000471301, 
Fusion gene scores* DoF score7 X 6 X 5=2105 X 3 X 4=60
# samples 95
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRCAM [Title/Abstract] AND BNC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A2QH-01BNRCAMchr7

108096687

-BNC2chr9

16583083

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000379028ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379028ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379028ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379028ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379028ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000413765ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000413765ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000413765ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000413765ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000413765ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000351718ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000351718ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000351718ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000351718ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000351718ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379024ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379024ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379024ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379024ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379024ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379022ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379022ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379022ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379022ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
5UTR-3CDSENST00000379022ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000425651ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000425651ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000425651ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000425651ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000425651ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000522550ENST00000380672NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000522550ENST00000380667NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000522550ENST00000545497NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000522550ENST00000380666NRCAMchr7

108096687

-BNC2chr9

16583083

-
intron-3CDSENST00000522550ENST00000471301NRCAMchr7

108096687

-BNC2chr9

16583083

-

Top

FusionProtFeatures for NRCAM_BNC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRCAM

Q92823

BNC2

Q6ZN30

Cell adhesion protein that is required for normalresponses to cell-cell contacts in brain and in the peripheralnervous system. Plays a role in neurite outgrowth in response tocontactin binding. Plays a role in mediating cell-cell contactsbetween Schwann cells and axons. Plays a role in the formation andmaintenance of the nodes of Ranvier on myelinated axons. Nodes ofRanvier contain clustered sodium channels that are crucial for thesaltatory propagation of action potentials along myelinated axons.During development, nodes of Ranvier are formed by the fusion oftwo heminodes. Required for normal clustering of sodium channelsat heminodes; not required for the formation of mature nodes withnormal sodium channel clusters. Required, together with GLDN, formaintaining NFASC and sodium channel clusters at mature nodes ofRanvier. {ECO:0000250|UniProtKB:Q810U4}. Probable transcription factor specific for skinkeratinocytes. May play a role in the differentiation ofspermatozoa and oocytes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NRCAM_BNC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NRCAM_BNC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRCAMPTPRB, CNTN2, HSPA12A, MACF1, MAGI3, LNX1, FRMD5, NTRK1BNC2IRF6, CHCHD10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NRCAM_BNC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NRCAM_BNC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRCAMC0004352Autistic Disorder2CTD_human
HgeneNRCAMC0009404Colorectal Neoplasms2CTD_human
HgeneNRCAMC0236969Substance-Related Disorders1CTD_human
HgeneNRCAMC1458155Mammary Neoplasms1CTD_human
TgeneBNC2C0008925Cleft Palate1CTD_human
TgeneBNC2C0376634Craniofacial Abnormalities1CTD_human
TgeneBNC2C0919267ovarian neoplasm1CTD_human