![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 24827 |
FusionGeneSummary for NRCAM_BNC2 |
![]() |
Fusion gene information | Fusion gene name: NRCAM_BNC2 | Fusion gene ID: 24827 | Hgene | Tgene | Gene symbol | NRCAM | BNC2 | Gene ID | 4897 | 54796 |
Gene name | neuronal cell adhesion molecule | basonuclin 2 | |
Synonyms | - | BSN2 | |
Cytomap | 7q31.1 | 9p22.3-p22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo | zinc finger protein basonuclin-2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q92823 | Q6ZN30 | |
Ensembl transtripts involved in fusion gene | ENST00000379028, ENST00000413765, ENST00000351718, ENST00000379024, ENST00000379022, ENST00000425651, ENST00000522550, | ENST00000380672, ENST00000380667, ENST00000545497, ENST00000380666, ENST00000471301, | |
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 5 X 3 X 4=60 |
# samples | 9 | 5 | |
** MAII score | log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NRCAM [Title/Abstract] AND BNC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NRCAM | GO:0045162 | clustering of voltage-gated sodium channels | 14602817 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AC-A2QH-01B | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000379028 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379028 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379028 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379028 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379028 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000413765 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000413765 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000413765 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000413765 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000413765 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000351718 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000351718 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000351718 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000351718 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000351718 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379024 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379024 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379024 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379024 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379024 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379022 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379022 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379022 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379022 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
5UTR-3CDS | ENST00000379022 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000425651 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000425651 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000425651 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000425651 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000425651 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000522550 | ENST00000380672 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000522550 | ENST00000380667 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000522550 | ENST00000545497 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000522550 | ENST00000380666 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
intron-3CDS | ENST00000522550 | ENST00000471301 | NRCAM | chr7 | 108096687 | - | BNC2 | chr9 | 16583083 | - |
Top |
FusionProtFeatures for NRCAM_BNC2 |
![]() |
Hgene | Tgene |
NRCAM | BNC2 |
Cell adhesion protein that is required for normalresponses to cell-cell contacts in brain and in the peripheralnervous system. Plays a role in neurite outgrowth in response tocontactin binding. Plays a role in mediating cell-cell contactsbetween Schwann cells and axons. Plays a role in the formation andmaintenance of the nodes of Ranvier on myelinated axons. Nodes ofRanvier contain clustered sodium channels that are crucial for thesaltatory propagation of action potentials along myelinated axons.During development, nodes of Ranvier are formed by the fusion oftwo heminodes. Required for normal clustering of sodium channelsat heminodes; not required for the formation of mature nodes withnormal sodium channel clusters. Required, together with GLDN, formaintaining NFASC and sodium channel clusters at mature nodes ofRanvier. {ECO:0000250|UniProtKB:Q810U4}. | Probable transcription factor specific for skinkeratinocytes. May play a role in the differentiation ofspermatozoa and oocytes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NRCAM_BNC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NRCAM_BNC2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NRCAM | PTPRB, CNTN2, HSPA12A, MACF1, MAGI3, LNX1, FRMD5, NTRK1 | BNC2 | IRF6, CHCHD10 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NRCAM_BNC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NRCAM_BNC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NRCAM | C0004352 | Autistic Disorder | 2 | CTD_human |
Hgene | NRCAM | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Hgene | NRCAM | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | NRCAM | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | BNC2 | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | BNC2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | BNC2 | C0919267 | ovarian neoplasm | 1 | CTD_human |