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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24817

FusionGeneSummary for NRAS_CLDN14

check button Fusion gene summary
Fusion gene informationFusion gene name: NRAS_CLDN14
Fusion gene ID: 24817
HgeneTgene
Gene symbol

NRAS

CLDN14

Gene ID

4893

23562

Gene nameNRAS proto-oncogene, GTPaseclaudin 14
SynonymsALPS4|CMNS|N-ras|NCMS|NRAS1|NS6DFNB29
Cytomap

1p13.2

21q22.13

Type of geneprotein-codingprotein-coding
DescriptionGTPase NRasN-ras protein part 4neuroblastoma RAS viral (v-ras) oncogene homologneuroblastoma RAS viral oncogene homologtransforming protein N-Rasv-ras neuroblastoma RAS viral oncogene homologclaudin-14
Modification date2018052720180411
UniProtAcc

P01111

O95500

Ensembl transtripts involved in fusion geneENST00000369535, ENST00000399136, 
ENST00000342108, ENST00000399139, 
ENST00000399137, ENST00000399135, 
ENST00000478313, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 2 X 3=24
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRAS [Title/Abstract] AND CLDN14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCHOLTCGA-W6-AA0S-01ANRASchr1

115258671

-CLDN14chr21

37834074

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369535ENST00000399136NRASchr1

115258671

-CLDN14chr21

37834074

-
5CDS-5UTRENST00000369535ENST00000342108NRASchr1

115258671

-CLDN14chr21

37834074

-
5CDS-5UTRENST00000369535ENST00000399139NRASchr1

115258671

-CLDN14chr21

37834074

-
5CDS-5UTRENST00000369535ENST00000399137NRASchr1

115258671

-CLDN14chr21

37834074

-
5CDS-5UTRENST00000369535ENST00000399135NRASchr1

115258671

-CLDN14chr21

37834074

-
5CDS-intronENST00000369535ENST00000478313NRASchr1

115258671

-CLDN14chr21

37834074

-

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FusionProtFeatures for NRAS_CLDN14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRAS

P01111

CLDN14

O95500

Ras proteins bind GDP/GTP and possess intrinsic GTPaseactivity. Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRAS_CLDN14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRAS_CLDN14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRASRAP1GDS1, MLLT4, PLCE1, RAF1, PIK3CG, DNAJB1, EEF1A1, SRI, RPS20, ELAVL1, CD2AP, RNASEH2B, VAT1, SPATS2, RGL2, RABGGTB, TMEM185A, FOXP4, RIN1, ABHD5, SLC39A12, CD97, SLC4A8, RTN1, TMEM206, GJB7, BZW2, THRB, GPR141, PAPOLA, PLP1, SLC37A3, RCE1, ICMT, SHOC2, PREX1, GOLGA7, BRAF, MAP2K7, NF1CLDN14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRAS_CLDN14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRAS_CLDN14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRASC1842036GIANT PIGMENTED HAIRY NEVUS6HPO;ORPHANET;UNIPROT
HgeneNRASC0025202melanoma5CTD_human;HPO
HgeneNRASC0334082NEVUS, EPIDERMAL (disorder)2UNIPROT
HgeneNRASC0349639Juvenile Myelomonocytic Leukemia2CTD_human;ORPHANET;UNIPROT
HgeneNRASC2674723RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER2ORPHANET;UNIPROT
HgeneNRASC0023487Acute Promyelocytic Leukemia1CTD_human
HgeneNRASC0024299Lymphoma1CTD_human;HPO
HgeneNRASC0027659Neoplasms, Experimental1CTD_human
HgeneNRASC0027819Neuroblastoma1CTD_human
HgeneNRASC0028326Noonan Syndrome1CTD_human;ORPHANET
HgeneNRASC0034885Rectal Neoplasms1CTD_human
HgeneNRASC0079731B-Cell Lymphomas1CTD_human
HgeneNRASC0206729Neurofibrosarcoma1CTD_human
HgeneNRASC1328840Autoimmune Lymphoproliferative Syndrome1CTD_human
HgeneNRASC1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
HgeneNRASC2750732Noonan Syndrome 61CTD_human;UNIPROT
HgeneNRASC2931367Thyroid cancer, follicular1CTD_human
TgeneCLDN14C3279660DEAFNESS, AUTOSOMAL RECESSIVE 292UNIPROT
TgeneCLDN14C0011053Deafness1CTD_human;HPO
TgeneCLDN14C0022650Kidney Calculi1CTD_human