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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2481

FusionGeneSummary for ARHGAP8_ACLY

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP8_ACLY
Fusion gene ID: 2481
HgeneTgene
Gene symbol

ARHGAP8

ACLY

Gene ID

23779

47

Gene nameRho GTPase activating protein 8ATP citrate lyase
SynonymsBPGAP1|PP610ACL|ATPCL|CLATP
Cytomap

22q13.31

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8ATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme
Modification date2018052220180523
UniProtAcc

P85298

P53396

Ensembl transtripts involved in fusion geneENST00000517296, ENST00000389773, 
ENST00000389774, ENST00000336963, 
ENST00000356099, ENST00000469872, 
ENST00000352035, ENST00000590151, 
ENST00000353196, ENST00000537919, 
ENST00000393896, ENST00000588779, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 47
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP8 [Title/Abstract] AND ACLY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103

TgeneACLY

GO:0006085

acetyl-CoA biosynthetic process

1371749

TgeneACLY

GO:0006101

citrate metabolic process

1371749

TgeneACLY

GO:0006107

oxaloacetate metabolic process

1371749

TgeneACLY

GO:0008610

lipid biosynthetic process

23932781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE840542ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
ChiTaRS3.1BE840465ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000517296ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000517296ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000517296ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000517296ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000517296ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000517296ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389773ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000389774ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000336963ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
5CDS-intronENST00000356099ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000352035ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000590151ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000353196ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000537919ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000393896ARHGAP8chr22

45255667

+ACLYchr17

40053157

-
intron-intronENST00000469872ENST00000588779ARHGAP8chr22

45255667

+ACLYchr17

40053157

-

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FusionProtFeatures for ARHGAP8_ACLY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP8

P85298

ACLY

P53396

ATP-citrate synthase is the primary enzyme responsiblefor the synthesis of cytosolic acetyl-CoA in many tissues. Has acentral role in de novo lipid synthesis. In nervous tissue it maybe involved in the biosynthesis of acetylcholine.{ECO:0000269|PubMed:23932781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP8_ACLY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP8_ACLY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP8_ACLY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP8_ACLY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACLYC0018801Heart failure1CTD_human
TgeneACLYC0028754Obesity1CTD_human
TgeneACLYC2239176Liver carcinoma1CTD_human