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Fusion gene ID: 24739 |
FusionGeneSummary for NPM1_RAB4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPM1_RAB4A | Fusion gene ID: 24739 | Hgene | Tgene | Gene symbol | NPM1 | RAB4A | Gene ID | 4869 | 5867 |
| Gene name | nucleophosmin 1 | RAB4A, member RAS oncogene family | |
| Synonyms | B23|NPM | HRES-1|HRES-1/RAB4|HRES1|RAB4 | |
| Cytomap | 5q35.1 | 1q42.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128 | ras-related protein Rab-4AHTLV-1 related endogenous sequence | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P06748 | P20338 | |
| Ensembl transtripts involved in fusion gene | ENST00000517671, ENST00000296930, ENST00000351986, ENST00000393820, | ENST00000366690, ENST00000473894, | |
| Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NPM1 [Title/Abstract] AND RAB4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NPM1 | GO:0006281 | DNA repair | 19188445 |
| Hgene | NPM1 | GO:0006334 | nucleosome assembly | 11602260 |
| Hgene | NPM1 | GO:0006913 | nucleocytoplasmic transport | 16041368 |
| Hgene | NPM1 | GO:0008104 | protein localization | 18420587 |
| Hgene | NPM1 | GO:0008284 | positive regulation of cell proliferation | 22528486 |
| Hgene | NPM1 | GO:0032071 | regulation of endodeoxyribonuclease activity | 19188445 |
| Hgene | NPM1 | GO:0034644 | cellular response to UV | 19160485 |
| Hgene | NPM1 | GO:0043066 | negative regulation of apoptotic process | 12882984 |
| Hgene | NPM1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 12882984 |
| Hgene | NPM1 | GO:0045727 | positive regulation of translation | 12882984 |
| Hgene | NPM1 | GO:0045893 | positive regulation of transcription, DNA-templated | 22528486 |
| Hgene | NPM1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19160485 |
| Hgene | NPM1 | GO:0051259 | protein complex oligomerization | 18809582 |
| Hgene | NPM1 | GO:0060699 | regulation of endoribonuclease activity | 19188445 |
| Hgene | NPM1 | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA | 12882984 |
| Hgene | NPM1 | GO:1902751 | positive regulation of cell cycle G2/M phase transition | 22528486 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1JL-01A | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000517671 | ENST00000366690 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| 5CDS-intron | ENST00000517671 | ENST00000473894 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| In-frame | ENST00000296930 | ENST00000366690 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| 5CDS-intron | ENST00000296930 | ENST00000473894 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| In-frame | ENST00000351986 | ENST00000366690 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| 5CDS-intron | ENST00000351986 | ENST00000473894 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| In-frame | ENST00000393820 | ENST00000366690 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
| 5CDS-intron | ENST00000393820 | ENST00000473894 | NPM1 | chr5 | 170815010 | + | RAB4A | chr1 | 229422233 | + |
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FusionProtFeatures for NPM1_RAB4A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPM1 | RAB4A |
| Protein transport. Probably involved in vesiculartraffic (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 1_9 | 19 | 295 | Compositional bias | Note=Met-rich |
| Hgene | NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 1_9 | 19 | 266 | Compositional bias | Note=Met-rich |
| Hgene | NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 1_9 | 19 | 260 | Compositional bias | Note=Met-rich |
| Hgene | NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 1_9 | 19 | 295 | Compositional bias | Note=Met-rich |
| Tgene | >RAB4A | chr5:170815010 | chr1:229422233 | ENST00000366690 | + | 0 | 8 | 42_50 | 10 | 835 | Motif | Effector region |
| Tgene | >RAB4A | chr5:170815010 | chr1:229422233 | ENST00000366690 | + | 0 | 8 | 126_129 | 10 | 835 | Nucleotide binding | GTP |
| Tgene | >RAB4A | chr5:170815010 | chr1:229422233 | ENST00000366690 | + | 0 | 8 | 156_158 | 10 | 835 | Nucleotide binding | GTP |
| Tgene | >RAB4A | chr5:170815010 | chr1:229422233 | ENST00000366690 | + | 0 | 8 | 20_28 | 10 | 835 | Nucleotide binding | GTP |
| Tgene | >RAB4A | chr5:170815010 | chr1:229422233 | ENST00000366690 | + | 0 | 8 | 68_72 | 10 | 835 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 120_132 | 19 | 295 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 161_188 | 19 | 295 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 120_132 | 19 | 266 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 161_188 | 19 | 266 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 120_132 | 19 | 260 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 161_188 | 19 | 260 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 120_132 | 19 | 295 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 161_188 | 19 | 295 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 152_157 | 19 | 295 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 191_197 | 19 | 295 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 152_157 | 19 | 266 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 191_197 | 19 | 266 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 152_157 | 19 | 260 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 191_197 | 19 | 260 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 152_157 | 19 | 295 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 191_197 | 19 | 295 | Motif | Nuclear localization signal |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000296930 | + | 1 | 11 | 243_294 | 19 | 295 | Region | Note=Required for nucleolar localization |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000351986 | + | 1 | 10 | 243_294 | 19 | 266 | Region | Note=Required for nucleolar localization |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000393820 | + | 1 | 10 | 243_294 | 19 | 260 | Region | Note=Required for nucleolar localization |
| Hgene | >NPM1 | chr5:170815010 | chr1:229422233 | ENST00000517671 | + | 2 | 12 | 243_294 | 19 | 295 | Region | Note=Required for nucleolar localization |
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FusionGeneSequence for NPM1_RAB4A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NPM1_ENST00000517671_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_228aa MEDSMDMDMSPLRPQNYLFDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRS YYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCA >In-frame_NPM1_ENST00000296930_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_228aa MEDSMDMDMSPLRPQNYLFDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRS YYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCA >In-frame_NPM1_ENST00000351986_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_228aa MEDSMDMDMSPLRPQNYLFDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRS YYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCA >In-frame_NPM1_ENST00000393820_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_228aa MEDSMDMDMSPLRPQNYLFDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRS YYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NPM1_ENST00000517671_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_684nt ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTATTGGAAAT GCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGT TCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGT TATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCC CGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCC TCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCA AGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCTTGAGACAG >In-frame_NPM1_ENST00000296930_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_684nt ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTATTGGAAAT GCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGT TCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGT TATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCC CGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCC TCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCA AGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCTTGAGACAG >In-frame_NPM1_ENST00000351986_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_684nt ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTATTGGAAAT GCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGT TCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGT TATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCC CGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCC TCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCA AGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCTTGAGACAG >In-frame_NPM1_ENST00000393820_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_684nt ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTATTGGAAAT GCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGT TCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGT TATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCC CGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCC TCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCA AGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCTTGAGACAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NPM1_ENST00000517671_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_2920nt GGGCGATGTCCTTGCTAATTTGGAGACTGATTCAGTCCCCTTTTGGCCCCCAAGTTACGTAAAGATAAGGACTTTGGAGATGTTTTCTCA GGAAGGACAGAGCTGAAAAACAAAGTTCCTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAG AACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTATTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAA AAATTCAAAGATGACTCAAATCATACAATAGGAGTGGAATTTGGTTCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATA TGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGACGAGAAGTTATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACC AGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAACAGATGCCCGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAAC AAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCTTAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGT GCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTACAGTGTGCAAGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAA AGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCTTGAGACAGCTGAGGTCACCGCGGCGCGCACAGGCCCCGAACGCTCAGGAGTGT GGTTGTTAGGAGAGCACACAGGTGTTCATACAGTGGCATTTGGGACACAATCGTTGGAACCTGAAGAATCTGAAGTTTTTTTTACCACCA TCTTTTTCTACTCTGTATGGAAGTAGATCTTTATGGGGAAAAGAGAATTTGGGGTGTTCTGCAAGCCAGTCAAAGTGGCACAGCAAATCA TATAAATCGAATTAAATGGACAACACCGTTAGATGTGTATGTAAAAATTTTCTGTTTCATATTTTTCCTTTCACTTTCGGTTTAAAACAT GCTATATGTACTGTATGTCCTGTAGCCCAGTGCGGCTCCACAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGT TTCAGATTTTATTTTTTTTAATCATATGAACTAAAATTGTCAATTGTGAGGTGTGCTTTTCTCATCATGTTGGTTATATTGCACAATTGG TTATATTTATGACCTGATATTCAAAGACTCTGGCATTGATAGCCAGTGTGTTTTCTTATTTAACTCCGTTTACTACATTCTACATGGTGT TTACGTGATCCACACTTGAAATACTAGATCAGTAGACATTCACTAATATACCAAAATAAAATGAAAAATTGAGTTTTTCCGTGAACTTTA TACTGTCCAGCTCTGTTGATTTTAAAGCCTCTTCATCCAGGTCAGTTCAGGAAGTATATCTGGAGTACCTGCTCTGTTTTTGGCTGTGAG ACTAGCACTAAGGATTCTGGTACCTTTACCCAAACCTACTGGGCTACTAATACTTCTCTCAGCAGTTGATCAAATACAATAGACCATGTA AGCTGGGGCCGCTCATCCACTTCCAGTTTGCTGGTCTCCCTGCTAGAAAACACATTGTACTGTGCTTTTTCTGGAATTCAGTATAATGGC ATCACTGCCTGTTTTTCACATCTTTTGTTTCCTGTTCATTTTAAGGAAACCTACTAAATCCAGTTAATATTAAATGGACACCACTCATTA AGAAATTTCTTTATGGCTTCTGCTGAATACTTAAATGCCTTACTACAGTTATCCAGTTGACATGTTTTTAATTCATATAAGGTATATTGG GTATATTGAAGTATATATTGTATTACAAAGACTTGTTCTTGTATTTTAAAATGTCAGTGCAAAAAATATATGGTGGAACCTTTCTTTAAA GTTGAAATGCAGTATTATTTAAATCTGAAAGGTTAAAAAGCTTTCTTCACCTTATATATGTTCTTCCACTGTGACTTTTTAGTTGAAGAC TAGTAAATTAACTTTTAGTTAGAAGATGCCTACTGCTTTTGTTGTTTATTTTAATCAGCAGAGCACAGAGACACATAAAAACTCTGGGAA ATGACTAGGATAAAAATATCAGTATGTATCTGTTTTAGATATTTTGAGTTTTGCTTTTTTTATGCCTTGAATATTTTATTTCAAAAAGTA TCTGAAGCAAATTCTCAGACTGAACTACTTCTTAGACCTCACTGTAAGAATATTTTATTCAATGTCTCATTTATGATAGATTTGCAAGCT GCTCATTTTTGAACAGCTTTTTGCATGGGATAGGAGCATGTCTATTCTAACACATCAGCTTATTCAAAAGCAAGAATTTTAAAAATAAGA TAAATGTAAAGTTGTTTTATAAACGATCCTGTTAATTAAACCACAGACACCATATATCCTTCTGCATCCTTTGGCCAATAAAAGTTGCTG GAGAACCAAACCATGGTGGTTCTTAATCAGGCTTTGCCTTTAGGGAGAATGAGGAGGAGAGATAATTGGGTATTGTTCAGGCTAGTAATA AATGTCATGTTTCTATTTCCCGCAACTCATTAAGTTTTCAGGAAGCTCTTAATTTAGATTTCTAGGAAAGTAATTATTCAGTCTTCCTAG AAAAAGATTATAAAGACCATTTAAACTGGAGATTGTAATTTATTCTTTTACAGTCCAGCATTTAAGTGAAAATGAGAACATCACAATTTG GGAATCTGTAATGGTTTTGTTGAAAACATTACTTGTGGCTTGTATAAGAGTGGCTGAATTCAAGAACATTGATTCTTAGCAGATCAATAA >In-frame_NPM1_ENST00000296930_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_3086nt AGTGCGCGTGCTCGGTGGGAGCCCGCGGAGTACCTGGAAGGAGGTGGGGGCGAGGTAGAAAGGAGTGGGGTTGAAAAGCGCTTGCGCAGG ACGGCTACGGTACGGGGGTGGGAGGGCTTCGGAGCACGCGCGCGGAGGCGGGACTTGGGAAGCGCTCGCGAGATCTTCAGGGTCTATATA TAAGCGCGGGGAGCCTGCGTCCTTTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCT TCTCTCCTACCTAAGTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGA TTTTTTGTTTAAGTTCTTGGTTATTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGA CTCAAATCATACAATAGGAGTGGAATTTGGTTCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGG ACAAGAACGATTCAGGTCCGTGACGAGAAGTTATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTA CAATGCGCTTACTAATTGGTTAACAGATGCCCGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGA TGCAGATCGTGAAGTTACCTTCTTAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGA GAATGTAGAAGAGGCTTTTGTACAGTGTGCAAGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGG TATTCAGTACGGAGATGCTGCCTTGAGACAGCTGAGGTCACCGCGGCGCGCACAGGCCCCGAACGCTCAGGAGTGTGGTTGTTAGGAGAG CACACAGGTGTTCATACAGTGGCATTTGGGACACAATCGTTGGAACCTGAAGAATCTGAAGTTTTTTTTACCACCATCTTTTTCTACTCT GTATGGAAGTAGATCTTTATGGGGAAAAGAGAATTTGGGGTGTTCTGCAAGCCAGTCAAAGTGGCACAGCAAATCATATAAATCGAATTA AATGGACAACACCGTTAGATGTGTATGTAAAAATTTTCTGTTTCATATTTTTCCTTTCACTTTCGGTTTAAAACATGCTATATGTACTGT ATGTCCTGTAGCCCAGTGCGGCTCCACAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGTTTCAGATTTTATTT TTTTTAATCATATGAACTAAAATTGTCAATTGTGAGGTGTGCTTTTCTCATCATGTTGGTTATATTGCACAATTGGTTATATTTATGACC TGATATTCAAAGACTCTGGCATTGATAGCCAGTGTGTTTTCTTATTTAACTCCGTTTACTACATTCTACATGGTGTTTACGTGATCCACA CTTGAAATACTAGATCAGTAGACATTCACTAATATACCAAAATAAAATGAAAAATTGAGTTTTTCCGTGAACTTTATACTGTCCAGCTCT GTTGATTTTAAAGCCTCTTCATCCAGGTCAGTTCAGGAAGTATATCTGGAGTACCTGCTCTGTTTTTGGCTGTGAGACTAGCACTAAGGA TTCTGGTACCTTTACCCAAACCTACTGGGCTACTAATACTTCTCTCAGCAGTTGATCAAATACAATAGACCATGTAAGCTGGGGCCGCTC ATCCACTTCCAGTTTGCTGGTCTCCCTGCTAGAAAACACATTGTACTGTGCTTTTTCTGGAATTCAGTATAATGGCATCACTGCCTGTTT TTCACATCTTTTGTTTCCTGTTCATTTTAAGGAAACCTACTAAATCCAGTTAATATTAAATGGACACCACTCATTAAGAAATTTCTTTAT GGCTTCTGCTGAATACTTAAATGCCTTACTACAGTTATCCAGTTGACATGTTTTTAATTCATATAAGGTATATTGGGTATATTGAAGTAT ATATTGTATTACAAAGACTTGTTCTTGTATTTTAAAATGTCAGTGCAAAAAATATATGGTGGAACCTTTCTTTAAAGTTGAAATGCAGTA TTATTTAAATCTGAAAGGTTAAAAAGCTTTCTTCACCTTATATATGTTCTTCCACTGTGACTTTTTAGTTGAAGACTAGTAAATTAACTT TTAGTTAGAAGATGCCTACTGCTTTTGTTGTTTATTTTAATCAGCAGAGCACAGAGACACATAAAAACTCTGGGAAATGACTAGGATAAA AATATCAGTATGTATCTGTTTTAGATATTTTGAGTTTTGCTTTTTTTATGCCTTGAATATTTTATTTCAAAAAGTATCTGAAGCAAATTC TCAGACTGAACTACTTCTTAGACCTCACTGTAAGAATATTTTATTCAATGTCTCATTTATGATAGATTTGCAAGCTGCTCATTTTTGAAC AGCTTTTTGCATGGGATAGGAGCATGTCTATTCTAACACATCAGCTTATTCAAAAGCAAGAATTTTAAAAATAAGATAAATGTAAAGTTG TTTTATAAACGATCCTGTTAATTAAACCACAGACACCATATATCCTTCTGCATCCTTTGGCCAATAAAAGTTGCTGGAGAACCAAACCAT GGTGGTTCTTAATCAGGCTTTGCCTTTAGGGAGAATGAGGAGGAGAGATAATTGGGTATTGTTCAGGCTAGTAATAAATGTCATGTTTCT ATTTCCCGCAACTCATTAAGTTTTCAGGAAGCTCTTAATTTAGATTTCTAGGAAAGTAATTATTCAGTCTTCCTAGAAAAAGATTATAAA GACCATTTAAACTGGAGATTGTAATTTATTCTTTTACAGTCCAGCATTTAAGTGAAAATGAGAACATCACAATTTGGGAATCTGTAATGG TTTTGTTGAAAACATTACTTGTGGCTTGTATAAGAGTGGCTGAATTCAAGAACATTGATTCTTAGCAGATCAATAATAGTATTTAAAGAA >In-frame_NPM1_ENST00000351986_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_2905nt AAGCGCGGGGAGCCTGCGTCCTTTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTT CTCTCCTACCTAAGTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGAT TTTTTGTTTAAGTTCTTGGTTATTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGAC TCAAATCATACAATAGGAGTGGAATTTGGTTCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGA CAAGAACGATTCAGGTCCGTGACGAGAAGTTATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTAC AATGCGCTTACTAATTGGTTAACAGATGCCCGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGAT GCAGATCGTGAAGTTACCTTCTTAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAG AATGTAGAAGAGGCTTTTGTACAGTGTGCAAGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGT ATTCAGTACGGAGATGCTGCCTTGAGACAGCTGAGGTCACCGCGGCGCGCACAGGCCCCGAACGCTCAGGAGTGTGGTTGTTAGGAGAGC ACACAGGTGTTCATACAGTGGCATTTGGGACACAATCGTTGGAACCTGAAGAATCTGAAGTTTTTTTTACCACCATCTTTTTCTACTCTG TATGGAAGTAGATCTTTATGGGGAAAAGAGAATTTGGGGTGTTCTGCAAGCCAGTCAAAGTGGCACAGCAAATCATATAAATCGAATTAA ATGGACAACACCGTTAGATGTGTATGTAAAAATTTTCTGTTTCATATTTTTCCTTTCACTTTCGGTTTAAAACATGCTATATGTACTGTA TGTCCTGTAGCCCAGTGCGGCTCCACAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGTTTCAGATTTTATTTT TTTTAATCATATGAACTAAAATTGTCAATTGTGAGGTGTGCTTTTCTCATCATGTTGGTTATATTGCACAATTGGTTATATTTATGACCT GATATTCAAAGACTCTGGCATTGATAGCCAGTGTGTTTTCTTATTTAACTCCGTTTACTACATTCTACATGGTGTTTACGTGATCCACAC TTGAAATACTAGATCAGTAGACATTCACTAATATACCAAAATAAAATGAAAAATTGAGTTTTTCCGTGAACTTTATACTGTCCAGCTCTG TTGATTTTAAAGCCTCTTCATCCAGGTCAGTTCAGGAAGTATATCTGGAGTACCTGCTCTGTTTTTGGCTGTGAGACTAGCACTAAGGAT TCTGGTACCTTTACCCAAACCTACTGGGCTACTAATACTTCTCTCAGCAGTTGATCAAATACAATAGACCATGTAAGCTGGGGCCGCTCA TCCACTTCCAGTTTGCTGGTCTCCCTGCTAGAAAACACATTGTACTGTGCTTTTTCTGGAATTCAGTATAATGGCATCACTGCCTGTTTT TCACATCTTTTGTTTCCTGTTCATTTTAAGGAAACCTACTAAATCCAGTTAATATTAAATGGACACCACTCATTAAGAAATTTCTTTATG GCTTCTGCTGAATACTTAAATGCCTTACTACAGTTATCCAGTTGACATGTTTTTAATTCATATAAGGTATATTGGGTATATTGAAGTATA TATTGTATTACAAAGACTTGTTCTTGTATTTTAAAATGTCAGTGCAAAAAATATATGGTGGAACCTTTCTTTAAAGTTGAAATGCAGTAT TATTTAAATCTGAAAGGTTAAAAAGCTTTCTTCACCTTATATATGTTCTTCCACTGTGACTTTTTAGTTGAAGACTAGTAAATTAACTTT TAGTTAGAAGATGCCTACTGCTTTTGTTGTTTATTTTAATCAGCAGAGCACAGAGACACATAAAAACTCTGGGAAATGACTAGGATAAAA ATATCAGTATGTATCTGTTTTAGATATTTTGAGTTTTGCTTTTTTTATGCCTTGAATATTTTATTTCAAAAAGTATCTGAAGCAAATTCT CAGACTGAACTACTTCTTAGACCTCACTGTAAGAATATTTTATTCAATGTCTCATTTATGATAGATTTGCAAGCTGCTCATTTTTGAACA GCTTTTTGCATGGGATAGGAGCATGTCTATTCTAACACATCAGCTTATTCAAAAGCAAGAATTTTAAAAATAAGATAAATGTAAAGTTGT TTTATAAACGATCCTGTTAATTAAACCACAGACACCATATATCCTTCTGCATCCTTTGGCCAATAAAAGTTGCTGGAGAACCAAACCATG GTGGTTCTTAATCAGGCTTTGCCTTTAGGGAGAATGAGGAGGAGAGATAATTGGGTATTGTTCAGGCTAGTAATAAATGTCATGTTTCTA TTTCCCGCAACTCATTAAGTTTTCAGGAAGCTCTTAATTTAGATTTCTAGGAAAGTAATTATTCAGTCTTCCTAGAAAAAGATTATAAAG ACCATTTAAACTGGAGATTGTAATTTATTCTTTTACAGTCCAGCATTTAAGTGAAAATGAGAACATCACAATTTGGGAATCTGTAATGGT TTTGTTGAAAACATTACTTGTGGCTTGTATAAGAGTGGCTGAATTCAAGAACATTGATTCTTAGCAGATCAATAATAGTATTTAAAGAAT >In-frame_NPM1_ENST00000393820_chr5_170815010_+_RAB4A_ENST00000366690_chr1_229422233_+_2883nt TTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTTCTCTCCTACCTAAGTGCGTGCC GCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGATTTTTTGTTTAAGTTCTTGGTTA TTGGAAATGCAGGAACTGGCAAATCTTGCTTACTTCATCAGTTTATTGAAAAAAAATTCAAAGATGACTCAAATCATACAATAGGAGTGG AATTTGGTTCAAAGATAATAAATGTTGGTGGTAAATATGTAAAGTTACAAATATGGGATACAGCAGGACAAGAACGATTCAGGTCCGTGA CGAGAAGTTATTACCGAGGCGCGGCCGGGGCTCTCCTCGTCTATGATATCACCAGCCGAGAAACCTACAATGCGCTTACTAATTGGTTAA CAGATGCCCGAATGCTAGCGAGCCAGAACATTGTGATCATCCTTTGTGGAAACAAGAAGGACCTGGATGCAGATCGTGAAGTTACCTTCT TAGAAGCCTCCAGATTTGCTCAAGAAAATGAGCTGATGTTTTTGGAAACAAGTGCGCTCACAGGGGAGAATGTAGAAGAGGCTTTTGTAC AGTGTGCAAGAAAAATACTTAACAAAATCGAATCAGGTGAGCTGGACCCAGAAAGAATGGGCTCAGGTATTCAGTACGGAGATGCTGCCT TGAGACAGCTGAGGTCACCGCGGCGCGCACAGGCCCCGAACGCTCAGGAGTGTGGTTGTTAGGAGAGCACACAGGTGTTCATACAGTGGC ATTTGGGACACAATCGTTGGAACCTGAAGAATCTGAAGTTTTTTTTACCACCATCTTTTTCTACTCTGTATGGAAGTAGATCTTTATGGG GAAAAGAGAATTTGGGGTGTTCTGCAAGCCAGTCAAAGTGGCACAGCAAATCATATAAATCGAATTAAATGGACAACACCGTTAGATGTG TATGTAAAAATTTTCTGTTTCATATTTTTCCTTTCACTTTCGGTTTAAAACATGCTATATGTACTGTATGTCCTGTAGCCCAGTGCGGCT CCACAGCATGGAATCTGATGTATGATATGATAGAATGTGGCACTAAATGCAGTTTCAGATTTTATTTTTTTTAATCATATGAACTAAAAT TGTCAATTGTGAGGTGTGCTTTTCTCATCATGTTGGTTATATTGCACAATTGGTTATATTTATGACCTGATATTCAAAGACTCTGGCATT GATAGCCAGTGTGTTTTCTTATTTAACTCCGTTTACTACATTCTACATGGTGTTTACGTGATCCACACTTGAAATACTAGATCAGTAGAC ATTCACTAATATACCAAAATAAAATGAAAAATTGAGTTTTTCCGTGAACTTTATACTGTCCAGCTCTGTTGATTTTAAAGCCTCTTCATC CAGGTCAGTTCAGGAAGTATATCTGGAGTACCTGCTCTGTTTTTGGCTGTGAGACTAGCACTAAGGATTCTGGTACCTTTACCCAAACCT ACTGGGCTACTAATACTTCTCTCAGCAGTTGATCAAATACAATAGACCATGTAAGCTGGGGCCGCTCATCCACTTCCAGTTTGCTGGTCT CCCTGCTAGAAAACACATTGTACTGTGCTTTTTCTGGAATTCAGTATAATGGCATCACTGCCTGTTTTTCACATCTTTTGTTTCCTGTTC ATTTTAAGGAAACCTACTAAATCCAGTTAATATTAAATGGACACCACTCATTAAGAAATTTCTTTATGGCTTCTGCTGAATACTTAAATG CCTTACTACAGTTATCCAGTTGACATGTTTTTAATTCATATAAGGTATATTGGGTATATTGAAGTATATATTGTATTACAAAGACTTGTT CTTGTATTTTAAAATGTCAGTGCAAAAAATATATGGTGGAACCTTTCTTTAAAGTTGAAATGCAGTATTATTTAAATCTGAAAGGTTAAA AAGCTTTCTTCACCTTATATATGTTCTTCCACTGTGACTTTTTAGTTGAAGACTAGTAAATTAACTTTTAGTTAGAAGATGCCTACTGCT TTTGTTGTTTATTTTAATCAGCAGAGCACAGAGACACATAAAAACTCTGGGAAATGACTAGGATAAAAATATCAGTATGTATCTGTTTTA GATATTTTGAGTTTTGCTTTTTTTATGCCTTGAATATTTTATTTCAAAAAGTATCTGAAGCAAATTCTCAGACTGAACTACTTCTTAGAC CTCACTGTAAGAATATTTTATTCAATGTCTCATTTATGATAGATTTGCAAGCTGCTCATTTTTGAACAGCTTTTTGCATGGGATAGGAGC ATGTCTATTCTAACACATCAGCTTATTCAAAAGCAAGAATTTTAAAAATAAGATAAATGTAAAGTTGTTTTATAAACGATCCTGTTAATT AAACCACAGACACCATATATCCTTCTGCATCCTTTGGCCAATAAAAGTTGCTGGAGAACCAAACCATGGTGGTTCTTAATCAGGCTTTGC CTTTAGGGAGAATGAGGAGGAGAGATAATTGGGTATTGTTCAGGCTAGTAATAAATGTCATGTTTCTATTTCCCGCAACTCATTAAGTTT TCAGGAAGCTCTTAATTTAGATTTCTAGGAAAGTAATTATTCAGTCTTCCTAGAAAAAGATTATAAAGACCATTTAAACTGGAGATTGTA ATTTATTCTTTTACAGTCCAGCATTTAAGTGAAAATGAGAACATCACAATTTGGGAATCTGTAATGGTTTTGTTGAAAACATTACTTGTG GCTTGTATAAGAGTGGCTGAATTCAAGAACATTGATTCTTAGCAGATCAATAATAGTATTTAAAGAATCTGATGCTAAAATTAGAAACCT |
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FusionGenePPI for NPM1_RAB4A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NPM1 | TCERG1, LYAR, USF2, HIST3H3, SWAP70, HAND2, NCL, OTUB1, AKT1, CDT1, RRP1B, GRB2, CENPF, CASKIN1, CDC14A, PIK3R1, NUP98, PPID, GRB7, NCAPG, NUMA1, NSUN2, PADI4, TP53, BARD1, BRCA1, H2AFX, CDKN2A, HMGA2, HMGA1, YY1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, EP300, PML, RARA, CTNNBL1, FANCA, FANCC, TFAP2A, HDAC1, HDAC2, SMARCA4, DOT1L, ACACA, HNRNPM, HNRNPU, DDX21, HIST1H1C, SIRT1, YBX1, PC, YBX3, H1FX, HIST1H1A, ESR1, CDK5RAP3, ZNF668, UBC, RYK, SMN1, CD4, YWHAQ, USP36, CTCF, HDAC5, CDKN1A, NOP56, CENPA, AFF1, DYRK2, TOP1, CDK2, SREK1, SENP3, RB1, PARP1, HJURP, ARRB1, ARRB2, SIRT7, NPM3, NPM1, FBXO25, IRF1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, MDM2, PA2G4, PPP2R1A, MID1, GZF1, APEX1, COPS2, PLCG1, FBXO6, GAPDH, SIAH1, PTBP1, SRSF1, APP, RPL14, RPS6, RPL24, RPL6, NAP1L1, HNRNPR, RPS4X, PRPF6, LAMP2, SURF4, RPL10L, NAP1L4, ZYX, NUP62, NUP50, RPL5, YWHAE, FMNL1, CPSF6, HNRNPH1, PAPOLG, JUNB, MC4R, HIVEP2, CPSF1, CPSF2, CPSF4, CPSF3, FN1, VCAM1, CSNK2A1, NOS2, UBL4A, ITGA4, CBX2, CBX4, CBX8, PHB, EIF2AK2, XPO1, GZMM, PAN2, CD81, IGSF8, ICAM1, PRKCZ, KIF11, SQSTM1, FLNA, LLGL1, HSP90AA1, TRIM21, TUBA1C, HSP90AB1, PARD6B, CDC37, TUBB3, MRPL46, KCTD2, CLTC, MRPL50, VCP, KCTD5, MRPL12, HSPA5, PTRF, MRPL52, EEF1A1, KCTD17, TAB1, BAG2, ANXA2, EIF5A, PPIL4, MRPL38, STK38, FLNB, LGALS1, C1QBP, COPB1, MRPL37, MRPL49, KEAP1, PRDX4, WDR26, PSMC4, SDPR, SLC25A3, RPS12, EEF1B2, NIPSNAP1, EEF1G, MRPL39, DDX3X, RNH1, OSBPL1A, EIF3H, MRPL54, ENO1, MYCBP, MRPL18, MAP1B, PSMD1, EEF1D, DNAJC13, HSPB1, CFL1, FLNC, PPP1CC, RPLP1, CEP152, SNRPD1, ATP5A1, ARHGAP5, PRKAR1A, MRPL53, GID8, YWHAZ, CCT2, EIF3E, LAMB2, DICER1, CHCHD4, MRPL19, SNRPD2, GRWD1, TPR, PSMD4, PSMC5, PPP2CA, UNC5C, SLC25A5, PTPN14, RPS5, TTC27, BOLA2, EIF4A1, TUFM, S100A10, IMPG1, NUDT21, UTRN, MRPL44, EIF3M, MRPL43, PKM, IMPDH2, TRRAP, CHCHD6, RANBP6, EIF3I, TAB2, MRPL24, DZIP1, IPO5, AGR2, MRPS30, ICT1, PRDX6, TCP1, RCOR1, GRN, TXN, RPLP0, PCBP1, MRPL28, MRPL10, TAF3, EPAS1, CHCHD3, TXNDC12, ELMO2, SRRT, MRPL11, EIF2S1, SNRPF, KTN1, FGD6, UQCRH, RBBP4, DNAJA1, CTTN, USP15, NUDCD1, RPS28, JAK1, PROS1, PYGB, KDR, EEF2, FASN, AKAP11, CSNK2B, DNAJA2, EIF3G, DHX15, MRPS26, HNRNPA0, DOCK4, PRKCI, VASP, COPE, SAMM50, TEX15, PSME3, PPM1G, COPG1, CALU, S100A11, HSPA4, PSMD12, POLR2E, TRIM28, SLAIN2, RPL10, GOLGA2, GOLGA3, PRKCA, IPO9, PARK7, SPIN1, PPA1, BANP, DSTN, GNAI2, HOXA7, ABCC1, RELA, ACY1, TARDBP, PARK2, KPNA1, ARMCX3, LIMCH1, OSBP, TRMT61A, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, ELF4, AURKA, HUWE1, FUS, COX8A, NPM2, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, SIRT6, EBNA1BP2, NOL12, RPL10A, POP4, ZNF22, NSA2, TAF1D, NIFK, RPL26L1, NIP7, RPL4, RPF1, CCDC137, KNOP1, RBM28, RPL7A, POP1, DDX24, FTSJ3, RRS1, RPL3, ZFP62, ZNF512, DDX56, DDX27, GLYR1, MAK16, CEBPZ, RSL1D1, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, C3orf17, RRP8, GNL2, PAPD5, RSL24D1, SURF6, GTPBP4, KIAA0020, NOP2, NVL, GLTSCR2, URB1, RPL23A, GPATCH4, TEX10, RPS8, NOC3L, BRIX1, DDX54, PWP1, RBM34, NMNAT1, CENPC, SENP5, RPL36AL, PAK1IP1, ZNF800, RPL7L1, RPL37A, RPF2, PELP1, NOC2L, RPP40, RBMX2, CENPV, PPAN-P2RY11, SDAD1, RPP38, RPP25, SPTY2D1, RPP25L, POP7, RPS6KB2, UTP15, NTRK1, EWSR1, CLK1, HIST1H3E, BYSL, CHD1, DDX1, DECR1, EIF1AX, EIF4G2, FBL, FAU, HIST1H1D, HIST1H1B, RPSA, MKI67, MPG, EXOSC10, RPL7, RPL8, RPL9, RPL11, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL27, RPL27A, RPL29, RPL32, RPL37, RPL38, RPS2, RPS3, RPS3A, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS29, SKIV2L, SRP72, XPC, IFRD2, HIST1H2BC, SMARCA5, CGGBP1, EIF3A, EIF3C, PABPC4, USP10, TTC37, JADE3, ABCF2, G3BP1, GNB2L1, EMG1, IGF2BP3, PSIP1, SUPT16H, RPL35, PDCD11, LARP4B, RRP12, LARP1, RPL13A, RPL36, MTHFD1L, AHCTF1, FAM98A, SERBP1, GNL3, SND1, NOB1, RPS27L, DDX47, EIF3L, RTCB, TRMT112, DHX29, MTPAP, NAT10, TSR1, NKRF, MEPCE, BCCIP, PNO1, MRPS22, WDR18, SCAF1, NOL6, DDX50, CCDC86, MUS81, ZNF622, DHX57, H2AFV, LARP4, WBSCR22, GAN, HEMGN, TMUB1, CRY1, DNAJB4, MCM2, GLI1, SP1, U2AF2, RC3H1, EIF2S2, EGFR, WWP2, CD24, ZNF746, DDX51, CYLD, INO80B, LMNA, YAP1, MTF1, BRD1, HDAC6 | RAB4A | CD2AP, PRKCI, KIF3B, TP53, RABEP1, RAB5A, GDI2, STX4, RAB7A, PIN1, RAB11FIP1, DYNC1LI1, ZFYVE28, HACE1, KCNA5, RUFY1, RBSN, BAG3, RABGAP1, PTTG1IP, IDH3A, GRIPAP1, RABEP2, ZNF830, VPS52, EXOC5, SCCPDH, EREG, GDI1, LAMP1, LRIG1, RAB2B, GRPR, SLC22A9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPM1_RAB4A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | NPM1 | P06748 | DB11638 | Artenimol | Nucleophosmin | small molecule | approved|investigational |
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RelatedDiseases for NPM1_RAB4A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NPM1 | C0023467 | Leukemia, Myelocytic, Acute | 3 | CTD_human |
| Hgene | NPM1 | C0023487 | Acute Promyelocytic Leukemia | 2 | CTD_human;ORPHANET |
| Hgene | NPM1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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